In Reply: Thrombocytopenia and Pediatric Patients With AIDS
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Based upon newly analyzed data, we agree with Dr Weinblatt's well-made point that HIV disease cannot be solely attributed to autoimmune destruction on the basis of elevated levels of platelet-associated IgG. In a recent prospective study of 38 infants and children with HIV infection monitored for as many as 9 years, we demonstrated that, using elevated platelet-associated IgG levels to detect AIDS thrombocytopenia, the sensitivity is 93% but the specificity is 13%. However, when combined with the finding of large circulating platelets as measured by increased mean platelet volume, the specificity is increased to 90%.
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2014 ◽
Vol 66
(4)
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pp. 437-440
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2012 ◽
Vol 23
(8)
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pp. 756-759
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2018 ◽
Vol 6
(3)
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2018 ◽
Vol 12
(10)
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pp. 2513-2518
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2011 ◽
Vol 57
(5)
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pp. e112-e113
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2019 ◽
Vol 6
(30)
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pp. 2024-2030
2009 ◽
Vol 206
(1)
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pp. 292-297
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