Is It a New Syndrome or Due to Overstimulation in the ICU?

PEDIATRICS ◽  
1990 ◽  
Vol 86 (2) ◽  
pp. 324-325
Author(s):  
JEFFREY PERLMAN ◽  
JOSEPH J. VOLPE

In Reply.— We appreciate the interest in our recent article that identified a previously unrecognized movement disorder in infants with bronchopulmonary dysplasia. We suspect from Dr Cole's comments that she can confirm some of our observations. However, her use of imprecise language makes it difficult to draw such a conclusion decisively. We refer to language such as "frantic movement," "disorganization in the motor system," "attempt to re-organize," "attempt to defend themselves from a stressful environment," "overtaxed autonomic system," "behavioral disorganization," "tongue thrusting... a learned behavioral response to stress," and "autonomic disorganization."

PEDIATRICS ◽  
1989 ◽  
Vol 84 (2) ◽  
pp. 215-218
Author(s):  
Jeffrey M. Perlman ◽  
Joseph J. Volpe

A previously unrecognized, striking movement disorder has been observed in 10 premature infants with severe bronchopulmonary dysplasia. Chronic hypoxemia, hypercarbia, bronchospasm, and inadequate nutrition were present in all. The movement disorder developed from approximately the third postnatal month. The dominant movements involve the limbs, neck, trunk, and oral-buccal-lingual structures. The limb movements were most prominent distally and consisted of rapid, random, jerky movements (similar to chorea) and "restless" movements (similar to akathisia). Similar movements of the neck and face were observed; tongue movements had a "darting" quality. The oral-buccal-lingual movements were similar to the dyskinesia of older patients. Movements were exacerbated during episodes of respiratory failure and attenuated during sleep. All infants exhibited feeding disorders, largely due to tongue movements. In 3 infants treated with clonazepam, there was striking improvement in motor function, including feeding. The natural history was partial or complete resolution or a static course. Thus, of the 7 surviving infants, the movements were absent (without therapy) at 15, 18, and 30 months of age. In the remaining 4 infants (3 of whom receive clonazepam), the movements, though attenuated, persisted at 6, 12, 15, and 21 months of age, respectively. Neuropathologically, 1 infant showed neuronal loss with astrocytosis in caudate, putamen, globus pallidus, and thalamus. These data defined a previously unrecognized extrapyramidal movement disorder of infants with severe bronchopulmonary dysplasia; pathogenesis may be related to chronic hypoxemia.


2017 ◽  
Vol 5 (4) ◽  
pp. 849-859 ◽  
Author(s):  
Xinyu Li ◽  
Dandan Sun ◽  
Xu Li ◽  
Dashuai Zhu ◽  
Zhenzhen Jia ◽  
...  

The synthesized PEGylation corannulene nanoparticles was examined in neural functions, which have effects on improving behavioral response to stress and promoting neurogenesis.


2008 ◽  
Vol 4 (1) ◽  
pp. 23 ◽  
Author(s):  
Katarzyna Nosek ◽  
Kristen Dennis ◽  
Brian M Andrus ◽  
Nasim Ahmadiyeh ◽  
Amber E Baum ◽  
...  

2015 ◽  
Vol 230 (3) ◽  
pp. 819-825 ◽  
Author(s):  
Adam S. Miner ◽  
Stephen M. Schueller ◽  
Emily G. Lattie ◽  
David C. Mohr

2005 ◽  
Vol 29 (8) ◽  
pp. 1214-1224 ◽  
Author(s):  
David A. Morilak ◽  
Gabe Barrera ◽  
David J. Echevarria ◽  
April S. Garcia ◽  
Angelica Hernandez ◽  
...  

2015 ◽  
Author(s):  
Adam S. Miner ◽  
Stephen M. Schueller ◽  
Emily G. Lattie ◽  
David C. Mohr

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