Ibuprofen for Fever

To the Editor.— I am writing to voice concern about the use of ibuprofen for simple antipyresis in infants and young children. Although there have been enough data about the new liquid preparation to convince the Federal Drug Administration to release it, it must be recognized that the total number of infants and young children reported who have received this drug is far from massive. Recognition of aseptic meningitis as a complication of ibuprofen therapy1,2 and reports of metabolic acidosis as a complication of overdosage3 are both relatively recent events.