scholarly journals Device-Related Thrombus After Left Atrial Appendage Closure

2019 ◽  
Vol 14 (1) ◽  
pp. 42-44 ◽  
Author(s):  
Philippe Garot ◽  
Bertrand Cormier ◽  
Jérôme Horvilleur
Keyword(s):  
Left Atrial ◽  
Time Course ◽  
Left Atrial Appendage ◽  
Oral Anticoagulants ◽  
Late Complications ◽  
Atrial Appendage ◽  
Left Atrial Appendage Closure ◽  
Increased Risk ◽  
Incidence Risk ◽  
Potential Benefits

Although left atrial appendage closure (LAAC) has proved non-inferior to oral anticoagulants in patients with AF, there has been recent concern about the occurrence of late complications, especially device-related thrombus (DRT), which was associated with increased risk of stroke. In this article, the incidence, risk factors and time course of DRT after LAAC are discussed, as well as the potential benefits of dedicated strategies in the management of DRT, which remain speculative, especially in patients with a contraindication to oral anticoagulants. In these patients, decision-making should be based on a multidisciplinary evaluation of the ischaemic/bleeding balance on an individual basis.

scholarly journals 45 * Real world experience left atrial appendage closure provides superior cost benefits relative to new and established oral anticoagulants

EP Europace ◽  
2014 ◽  
Vol 16 (suppl 3) ◽  
pp. iii17-iii17
Author(s):  
S. Panikker ◽  
J. Lord ◽  
J. Jarman ◽  
J. P. Foran ◽  
S. Haldar ◽  
...  
Keyword(s):  
Real World ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Oral Anticoagulants ◽  
Atrial Appendage ◽  
Left Atrial Appendage Closure ◽  
Cost Benefits

scholarly journals Left Atrial Appendage: Physiology, Pathology, and Role as a Therapeutic Target

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Damiano Regazzoli ◽  
Francesco Ancona ◽  
Nicola Trevisi ◽  
Fabrizio Guarracini ◽  
Andrea Radinovic ◽  
...  
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Oral Anticoagulants ◽  
Blood Stasis ◽  
Atrial Appendage ◽  
Low Flow ◽  
Left Atrial Appendage Occlusion ◽  
Poor Patient Compliance ◽  
Increased Risk ◽  
Variable Morphology

Atrial fibrillation (AF) is the most common clinically relevant cardiac arrhythmia. AF poses patients at increased risk of thromboembolism, in particular ischemic stroke. The CHADS2 and CHA2DS2-VASc scores are useful in the assessment of thromboembolic risk in nonvalvular AF and are utilized in decision-making about treatment with oral anticoagulation (OAC). However, OAC is underutilized due to poor patient compliance and contraindications, especially major bleedings. The Virchow triad synthesizes the pathogenesis of thrombogenesis in AF: endocardial dysfunction, abnormal blood stasis, and altered hemostasis. This is especially prominent in the left atrial appendage (LAA), where the low flow reaches its minimum. The LAA is the remnant of the embryonic left atrium, with a complex and variable morphology predisposing to stasis, especially during AF. In patients with nonvalvular AF, 90% of thrombi are located in the LAA. So, left atrial appendage occlusion could be an interesting and effective procedure in thromboembolism prevention in AF. After exclusion of LAA as an embolic source, the remaining risk of thromboembolism does not longer justify the use of oral anticoagulants. Various surgical and catheter-based methods have been developed to exclude the LAA. This paper reviews the physiological and pathophysiological role of the LAA and catheter-based methods of LAA exclusion.

Gender-specific differences in patients who underwent left atrial appendage closure

2021 ◽  
Author(s):  
Issameddine Ajmi ◽  
Steffen Schnupp ◽  
Majdi Amami ◽  
Christian Mahnkopf
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Oral Anticoagulants ◽  
Self Care ◽  
Female Gender ◽  
Atrial Appendage ◽  
Health State ◽  
Left Atrial Appendage Closure ◽  
Gender Specific Differences ◽  
Gender Specific

Aim: We aimed to study gender-specific differences in patients who underwent left atrial appendage closure (LAAC). Materials & methods: A total of 201 consecutive patients who underwent LAAC were enrolled. The EQ-5D-3L questionnaire was employed before and 3 months post-LAAC to study the quality of life. Results: Women had a higher score for Anxiety/Depression before implantation. Three months after LAAC, both groups showed a significant improvement in mobility, self-care and usual activities. The female gender had a significant improvement in health state 3 months after implantation than their male counterparts. Conclusion: Our data shows an improvement in mobility, self-care, usual activities and the overall health state in all patients after LAAC. This potential improvement, most likely caused by the discontinuation of oral anticoagulants, should be considered an indication for LAAC.

scholarly journals Left Atrial Appendage Closure Versus Oral Anticoagulants in Atrial Fibrillation

2020 ◽  
Vol 76 (23) ◽  
pp. 2795-2797
Author(s):  
Mohit K. Turagam ◽  
Pavel Osmancik ◽  
Petr Neuzil ◽  
Srinivas R. Dukkipati ◽  
Vivek Y. Reddy
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Oral Anticoagulants ◽  
Atrial Appendage ◽  
Left Atrial Appendage Closure
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