Autoimmune comorbidity and microvascular complications in childhood-onset type 1 diabetes after 20 years of diabetes duration. A questionnaire study

2012 ◽  
Vol 153 (6) ◽  
pp. 222-226
Author(s):  
Katalin H. Nagy ◽  
Barnabás Rózsai ◽  
Kálmán Kürti ◽  
Ilona Rippl ◽  
Éva Erhardt ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Microvascular Complications ◽  
Thyroid Autoimmunity ◽  
Vascular Complications ◽  
Population Based ◽  
Diabetes Duration ◽  
Childhood Onset ◽  
Onset Type

There are no population-based data on the autoimmune morbidity and vascular complications of young adults with childhood-onset type 1 diabetes in Hungary. Aims: To assess the prevalence of these morbidities after 20 years of diabetes duration. Method: Postal questionnaire. Results: 6.2% of the patients had celiac disease. Diabetes was diagnosed at a significantly earlier age in patients with diabetes and celiac disease as compared to those without celiac diasease. Thyroid autoimmunity was reported in 7.6% of cases. They were significantly older with longer duration of diabetes. Every fifth patients reported retinopathy, one sixth of patients was treated for hypertension. Neuropathy was found in 3.4% and kidney disease in 4.8% of the cases. Conclusions: Apart from retinopathy and hypertension, the prevalence of microvascular complications was relatively low. Considering the limitations of questionnaire studies, laboratory screening is warranted to assess the true prevalence of comorbidities and complications. Orv. Hetil., 2012, 153, 222–226.

Microvascular Complications in Childhood-Onset Type 1 Diabetes and Celiac Disease: A Multicenter Longitudinal Analysis of 56,514 Patients From the German-Austrian DPV Database

Diabetes Care ◽  
2015 ◽  
Vol 38 (5) ◽  
pp. 801-807 ◽  
Author(s):  
Tilman R. Rohrer ◽  
Johannes Wolf ◽  
Susanne Liptay ◽  
Klaus-Peter Zimmer ◽  
Elke Fröhlich-Reiterer ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Longitudinal Analysis ◽  
Microvascular Complications ◽  
Childhood Onset ◽  
Onset Type

Impact of childhood-onset type 1 diabetes on schooling: a population-based register study

Diabetologia ◽  
2013 ◽  
Vol 56 (6) ◽  
pp. 1254-1262 ◽  
Author(s):  
S. Persson ◽  
G. Dahlquist ◽  
U.-G. Gerdtham ◽  
K. Steen Carlsson
Keyword(s):  
Type 1 Diabetes ◽  
Population Based ◽  
Register Study ◽  
Childhood Onset ◽  
Onset Type

scholarly journals Microvascular Outcomes of Pediatric-Onset Type 1 Diabetes Mellitus: A Single-Center Observational Case Reviews in Sana’a, Yemen

2018 ◽  
Vol 11 ◽  
pp. 117955141774921
Author(s):  
Abdallah Ahmed Gunaid
Keyword(s):  
Type 1 Diabetes ◽  
Low Income ◽  
Microvascular Complications ◽  
Thyroid Autoimmunity ◽  
Low Income Countries ◽  
Overt Hypothyroidism ◽  
Onset Type ◽  
Pediatric Onset

Microvascular complications of pediatric-onset type 1 diabetes are common in low-income countries. In this study, we aimed at reviewing microvascular outcomes in 6 cases with type 1 diabetes over 14 to 31 years of follow-up. Severe proliferative diabetic retinopathy (PDR) and/or diabetic macular edema (maculopathy) (DME) and overt diabetic nephropathy (macroalbuminuria) were seen among 4 of 6 patients, whereas severe diabetic peripheral neuropathy with Charcot neuroarthropathy was seen in 1 patient only, who had the longest duration of follow-up. The weighted mean (SD) (95% confidence interval) hemoglobin A1c was 8.9 (1.6) (8.4-9.4)% [74 (17) (68-80) mmol/mol] for PDR/DME and 8.6 (1.7) (8.0-9.0)% [71 (19) (65-77) mmol/mol] for macroalbuminuria. Thyroid autoimmunity was positive in 3 patients with overt hypothyroidism in 2 of them. Worse microvascular outcomes among these cases might be attributed to poor glycemic control, lack of knowledge, and limited financial resources.

scholarly journals Persistent C-peptide levels and microvascular complications in childhood onset type 1 diabetes of long duration

2019 ◽  
Vol 33 (9) ◽  
pp. 657-661 ◽  
Author(s):  
Katherine V. Williams ◽  
Dorothy J. Becker ◽  
Trevor J. Orchard ◽  
Tina Costacou
Keyword(s):  
Type 1 Diabetes ◽  
Microvascular Complications ◽  
Childhood Onset ◽  
C Peptide ◽  
Onset Type ◽  
Long Duration

scholarly journals Cause-Specific Mortality Trends in a Large Population-Based Cohort With Long-Standing Childhood-Onset Type 1 Diabetes

Diabetes ◽  
2010 ◽  
Vol 59 (12) ◽  
pp. 3216-3222 ◽  
Author(s):  
A. M. Secrest ◽  
D. J. Becker ◽  
S. F. Kelsey ◽  
R. E. LaPorte ◽  
T. J. Orchard
Keyword(s):  
Type 1 Diabetes ◽  
Large Population ◽  
Population Based ◽  
Childhood Onset ◽  
Mortality Trends ◽  
Onset Type ◽  
Specific Mortality

scholarly journals Modification of the Association Between Severe Hypoglycemia and Ischemic Heart Disease by Surrogates of Vascular Damage Severity in Type 1 Diabetes During ∼30 Years of Follow-up in the DCCT/EDIC Study

2021 ◽  
Author(s):  
Elke R. Fahrmann ◽  
Laura Adkins ◽  
Henry K. Driscoll
Keyword(s):  
Type 1 Diabetes ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Microvascular Complications ◽  
Vascular Complications ◽  
Severe Hypoglycemia ◽  
Vascular Damage ◽  
Diabetes Duration ◽  
Ischemic Heart

OBJECTIVE <p>Literature suggests that severe hypoglycemia (SH) may be linked to cardiovascular events only in older individuals with high cardiovascular risk score (CV-score). Whether a potential relationship between any-SH and cardiovascular disease exists and whether it is conditional on vascular damage severity in a young type 1 diabetes (T1D) cohort without apparent macro-vascular and no or mild-to-moderate micro-vascular complications at baseline is unknown.</p> <p>RESEARCH DESIGN AND METHODS</p> <p>We evaluated data of 1441 Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) volunteers (diabetes duration 1-15 years) followed for ~30 years. Time-dependent associations between any-SH, interactions of any-SH with surrogates of baseline micro-/macro- vascular damage severity (diabetes duration, Early Treatment Diabetic Retinopathy Study scale (ETDRS), Diabetes Complications Severity Index (DCSI), or CV-scores) and ischemic heart disease (IHD: death, silent/nonfatal myocardial infarct, revascularization, or confirmed angina) were analyzed.</p> <p>RESULTS</p> <p>Without interactions, in the minimal adjusted model controlling for confounding bias by age and HbA1c, SH was a significant IHD factor (p~0.003). SH remained a significant factor for IHD in fully adjusted models (p<0.05). In models with interactions, interactions between SH and surrogates of microvascular complications severity, but not between SH and CV-score, were significant. Hazard ratios for IHD based on SH increased 1.19-fold, 1.32-fold, and 2.21-fold for each additional year of diabetes duration, ETDRS-unit, and DCSI-unit, respectively. At time of IHD event, ~15% of 110 participants with SH had high CV-scores.</p> <p> </p> <p>CONCLUSION</p> <p>In a young T1D cohort with no baseline macrovascular complications, surrogates of baseline microvascular damage severity impact the effect of SH on IHD. Older age with high CV-score per se is not mandatory for an association of SH with IHD. However, the association is multifactorial.</p>

scholarly journals Increasing risk of psychiatric morbidity after childhood onset type 1 diabetes: a population-based cohort study

Diabetologia ◽  
2017 ◽  
Vol 61 (4) ◽  
pp. 831-838 ◽  
Author(s):  
Daniel Dybdal ◽  
Janne S. Tolstrup ◽  
Stine M. Sildorf ◽  
Kirsten A. Boisen ◽  
Jannet Svensson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Psychiatric Morbidity ◽  
Population Based ◽  
Childhood Onset ◽  
Onset Type ◽  
Increasing Risk
Sign in / Sign up

Export Citation Format

Share Document