Measurement of blood pressure variability and the clinical value

Authors have collected and analyzed literature data on blood pressure variability. They present the methods of blood pressure variability measurement, clinical value and relationships with target organ damages and risk of presence of cardiovascular events. They collect data about the prognostic value of blood pressure variability and the effects of different antihypertensive drugs on blood pressure variability. They underline that in addition to reduction of blood pressure to target value, it is essential to influence blood pressure fluctuation and decrease blood pressure variability, because blood pressure fluctuation presents a major threat for the hypertensive subjects. Data from national studies are also presented. They welcome that measurement of blood pressure variability has been included in international guidelines. Orv. Hetil., 2014, 155(42), 1661–1672.

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Impact of visit-to-visit blood pressure variability on hypertensive-mediated target organ damage and future cardiovascular events

Journal of Hypertension ◽

10.1097/hjh.0000000000002847 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Costantino Mancusi ◽

Valentina Trimarco ◽

Maria Angela Losi ◽

Grazia Canciello ◽

Carmine Morisco ◽

...

Keyword(s):

Blood Pressure ◽

Cardiovascular Events ◽

Blood Pressure Variability ◽

Target Organ Damage ◽

Organ Damage ◽

Target Organ

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Blood Pressure Variability: Prognostic Value and Therapeutic Implications

ISRN Hypertension ◽

10.5402/2013/398485 ◽

2013 ◽

Vol 2013 ◽

pp. 1-16 ◽

Cited By ~ 22

Author(s):

Christian Höcht

Keyword(s):

Blood Pressure ◽

Cardiovascular Disease ◽

Clinical Trials ◽

Cardiovascular Events ◽

Blood Pressure Variability ◽

Prognostic Value ◽

Left Ventricular ◽

Renal Lesion ◽

Short Term

Blood pressure variability (BPV) is considered nowadays a novel risk factor for cardiovascular disease. Early findings in sinoaortic denervated rats have clearly shown that enhanced fluctuation of blood pressure induced left ventricular hypertrophy, vascular stiffness, and renal lesion. A large number of clinical trials confirm that short-term and long-term blood pressure variability independently contributes to target organ damage, cardiovascular events, and mortality not only in hypertensive patients but also in subjects with diabetes mellitus and chronic kidney disease. Therefore, amelioration of BPV has been suggested as an additional target of the treatment of cardiovascular diseases. Preliminary evidence obtained from meta-analysis and controlled clinical trials has shown that antihypertensive classes differ in their ability to control excessive BP fluctuations with an impact in the prevention of cardiovascular events. Calcium channel blockers seem to be more effective than other blood pressure lowering drugs for the reduction of short-term and long-term BPV. In order to increase actual knowledge regarding the prognostic value and therapeutic significance of BPV in cardiovascular disease, there is a need for additional clinical studies specifically designed for the study of the relevance of short-term and long-term BPV control by antihypertensive drugs.

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