Decreased Macrophage Density on Carbon Nanofiber Patterns

2006 ◽  
Vol 950 ◽  
Author(s):  
Jong Youl Kim ◽  
Dongwoo Khang ◽  
Jong Eun Lee ◽  
Thomas J. Webster
Keyword(s):  
Carbon Nanofibers ◽  
Polymer Matrix ◽  
Carbon Nanofiber ◽  
In Vitro Study ◽  
Inflammatory Cells ◽  
Vitro Study ◽  
Macrophage Density ◽  
Macrophage Adhesion ◽  
First Time

ABSTRACTIn this study, we describe the selective adhesion 4 hour and proliferation 24 hour and 4 days of inflammatory cells (specifically, macrophages) on aligned carbon nanofiber/nanotube patterns on a polymer matrix. The results showed for the first time that macrophage adhesion and proliferation on aligned Carbon nanofibers (CNFs) was significantly less than on the polymer matrix. The present in vitro study thus provided evidence of the ability of CNFs to down-regulate macrophage adhesion and proliferation important to decrease harmful body reaction, which is imperative for the future consideration of CNFs for numerous implant applications.

Increased, Directed Osteoblast Adhesion at Nanophase Ti and Ti6Al4V Particle Boundaries

2003 ◽  
Vol 806 ◽  
Author(s):  
Thomas J. Webster ◽  
Jeremiah U. Ejiofor
Keyword(s):  
Carbon Nanofibers ◽  
Metal Particle ◽  
Glycolic Acid ◽  
In Vitro Study ◽  
Vitro Study ◽  
Orthopedic Implant ◽  
Grain Sizes ◽  
Nanophase Materials ◽  
Osteoblast Adhesion

ABSTRACTIncreased functions of osteoblasts (bone-forming cells) have been demonstrated on nanophase compared to conventional ceramics (specifically, alumina, titania, and hydroxyapatite), polymers (such as poly-lactic-glycolic acid and polyurethane), carbon nanofibers, and composites thereof. Nanophase materials are materials that simulate dimensions of constituent components of bone since they possess particle or grain sizes less than 100 nm. However, to date, interactions of osteoblasts on nanophase compared to conventional metals remain to be elucidated. For this reason, the objective of the present in vitro study was to design, fabricate, and evaluate osteoblast adhesion on nanophase metals (specifically, Ti and Ti6Al4V). Results of this study provided the first evidence of increased osteoblast adhesion on nanophase compared to conventional Ti-based metals. Moreover, directed osteoblast adhesion was observed preferentially at metal particle boundaries. It is speculated that since more particle boundaries were created through the use of nanophase compared to conventional metals, increased osteoblast adhesion resulted. Because adhesion is a necessary prerequisite for subsequent functions of osteoblasts (such as deposition of calcium-containing mineral), the present study suggests that Ti-based nanophase metals should be further considered for orthopedic implant applications.

scholarly journals Pro-inflammatory effects of palytoxin: an in vitro study on human keratinocytes and inflammatory cells

2016 ◽  
Vol 5 (4) ◽  
pp. 1172-1181 ◽  
Author(s):  
Marco Pelin ◽  
Chiara Florio ◽  
Cristina Ponti ◽  
Marianna Lucafò ◽  
Davide Gibellini ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Inflammatory Cells ◽  
Human Keratinocytes ◽  
Vitro Study

Keratinocytes are actively involved in the recruitment of inflammatory cells in response to cutaneous contact with palytoxin.

scholarly journals In vitro study of the inflammatory cells response to biodegradable Mg-based alloy extract

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0193276 ◽  
Author(s):  
Liang Jin ◽  
Jing Wu ◽  
Guangyin Yuan ◽  
Tongxin Chen
Keyword(s):  
In Vitro Study ◽  
Inflammatory Cells ◽  
Vitro Study

In vitro study of the interaction between human gut microbiota and herbal extracts using willow bark extract as an example

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
EM Pferschy-Wenzig ◽  
K Koskinen ◽  
C Moissl-Eichinger ◽  
R Bauer
Keyword(s):  
Gut Microbiota ◽  
In Vitro Study ◽  
Vitro Study ◽  
Bark Extract ◽  
Herbal Extracts ◽  
Human Gut ◽  
Human Gut Microbiota ◽  
Willow Bark
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