Continuous force-displacement relationships for the human red blood cell at different erythrocytic developmental stages ofPlasmodium falciparummalaria parasite

2004 ◽  
Vol 844 ◽  
Author(s):  
John P. Mills ◽  
Lan Qie ◽  
Ming Dao ◽  
Kevin S. W. Tan ◽  
Chwee Teck Lim ◽  
...  
Keyword(s):  
Blood Cell ◽  
Optical Tweezers ◽  
Red Blood Cell ◽  
Mechanical Response ◽  
Developmental Stages ◽  
Three Dimensional ◽  
Parasite Development ◽  
Human Red Blood Cells ◽  
Infected Rbcs ◽  
Order Of Magnitude

ABSTRACTPrior work involving either aspiration of infected cells into micropipette under suction pressure or deformation in laminar shear flow revealed that the malaria parasitePlasmodium (P.) falciparumcould result in significant stiffening of infected human red blood cells (RBCs). In this paper, we present optical tweezers studies of progressive changes to nonlinear mechanical response of infected RBCs at different developmental stages ofP. falciparum.From early ring stage to late trophozoite and schizont stages, up to an order of magnitude increase in shear modulus was found under controlled mechanical loading by combining experiments with three-dimensional computational simulations. These results provide novel approaches to study changes in mechanical deformability in the advanced stages of parasite development in the erythrocyte, and suggest a significantly greater stiffening of the red blood cell due toP. falciparuminvasion than that considered from previous studies.

Mechanical response of human red blood cells in health and disease: Some structure-property-function relationships

2006 ◽  
Vol 21 (8) ◽  
pp. 1871-1877 ◽  
Author(s):  
S. Suresh
Keyword(s):  
Molecular Structure ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Mechanical Response ◽  
Structure Property ◽  
Human Red Blood Cells ◽  
Health And Disease ◽  
Cell Elasticity ◽  
Altered Cell ◽  
Structure Properties

Aspects of mechanical deformability and biorheology of the human red blood cell are known to play a pivotal role in influencing organ function as well as states of overall health and disease. In this article, consequences of alterations to the membrane and cytoskeletal molecular structure of the human red blood cell are considered in the context of an infectious disease,Plasmodium falciparummalaria, and several hereditary hemolytic disorders: spherocytosis, elliptocytosis, and sickle cell anemia. In each of these cases, the effects of altered cell shape or molecular structure on cell elasticity, motility, and biorheology are examined. These examples are used to gain broad perspectives on the connections among cell and subcellular structure, properties, and disease at the intersections of engineering, biology, and medicine.

scholarly journals Modelling and rapid simulation of multiple red blood cell light scattering

2006 ◽  
Vol 3 (11) ◽  
pp. 823-831 ◽  
Author(s):  
T.I Zohdi ◽  
F.A Kuypers
Keyword(s):  
Light Scattering ◽  
Blood Cell ◽  
Red Blood Cells ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Three Dimensional ◽  
Computational Framework ◽  
Desktop Computers ◽  
Order Of Magnitude ◽  
Scattering Response

The goal of this work is to develop a computational framework to rapidly simulate the light scattering response of multiple red blood cells. Because the wavelength of visible light (3.8×10 −7  m≤ λ ≤7.2×10 −7  m) is approximately an order of magnitude smaller than the diameter of a typical red blood cell scatterer ( d ≈8×10 −6  m), geometric ray-tracing theory is applicable, and can be used to quickly ascertain the amount of optical energy, characterized by the Poynting vector, that is reflected and absorbed by multiple red blood cells. The overall objective is to provide a straightforward approach that can be easily implemented by researchers in the field, using standard desktop computers. Three-dimensional examples are given to illustrate the approach and the results compare quite closely to experiments on blood samples conducted at the Children's Hospital Oakland Research Institute (CHORI).

scholarly journals On the effects of membrane viscosity on transient red blood cell dynamics

Soft Matter ◽  
2020 ◽  
Vol 16 (26) ◽  
pp. 6191-6205 ◽  
Author(s):  
Fabio Guglietta ◽  
Marek Behr ◽  
Luca Biferale ◽  
Giacomo Falcucci ◽  
Mauro Sbragaglia
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Circulation ◽  
Hydraulic Properties ◽  
Large Scale ◽  
Mechanical Response ◽  
Cell Dynamics ◽  
Membrane Viscosity

Computational Fluid Dynamics is currently used to design and improve the hydraulic properties of biomedical devices, wherein the large scale blood circulation needs to be simulated by accounting for the mechanical response of RBCs at the mesoscale.

scholarly journals Dynamic deformation of red blood cell
in Dual-trap Optical Tweezers

2010 ◽  
Vol 18 (10) ◽  
pp. 10462 ◽  
Author(s):  
Sebastien Rancourt-Grenier ◽  
Ming-Tzo Wei ◽  
Jar-Jin Bai ◽  
Arthur Chiou ◽  
Paul P. Bareil ◽  
...  
Keyword(s):  
Blood Cell ◽  
Optical Tweezers ◽  
Red Blood Cell ◽  
Dynamic Deformation

scholarly journals Determination of red blood cell deformability using centrifugal force in a three-dimensional-printed mini-disk (3D-PMD)

PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0197619 ◽  
Author(s):  
Hyunjung Lim ◽  
Seung Min Back ◽  
Jeonghun Nam ◽  
Hyuk Choi
Keyword(s):  
Blood Cell ◽  
Centrifugal Force ◽  
Red Blood Cell ◽  
Three Dimensional ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

scholarly journals Optical tweezers study of red blood cell aggregation and disaggregation in plasma and protein solutions

2016 ◽  
Vol 21 (3) ◽  
pp. 035001 ◽  
Author(s):  
Kisung Lee ◽  
Matti Kinnunen ◽  
Maria D. Khokhlova ◽  
Evgeny V. Lyubin ◽  
Alexander V. Priezzhev ◽  
...  
Keyword(s):  
Blood Cell ◽  
Optical Tweezers ◽  
Red Blood Cell ◽  
Cell Aggregation ◽  
Protein Solutions ◽  
Red Blood Cell Aggregation ◽  
Aggregation And Disaggregation ◽  
Blood Cell Aggregation
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