Evaluation of Amyloid Polypeptide Aggregation Inhibition and Disaggregation Activity of A-Type Procyanidins

The number of people worldwide suffering from Alzheimer’s disease (AD) and type 2 diabetes (T2D) is on the rise. Amyloid polypeptides are thought to be associated with the onset of both diseases. Amyloid-β (Aβ) that aggregates in the brain and human islet amyloid polypeptide (hIAPP) that aggregates in the pancreas are considered cytotoxic and the cause of the development of AD and T2D, respectively. Thus, inhibiting amyloid polypeptide aggregation and disaggregation existing amyloid aggregates are promising approaches in the therapy and prevention against both diseases. Therefore, in this research, we evaluated the Aβ/hIAPP anti-aggregation and disaggregation activities of A-type procyanidins 1–7 and their substructures 8 and 9, by conducting structure–activity relationship studies and identified the active site. The thioflavin-T (Th-T) assay, which quantifies the degree of aggregation of amyloid polypeptides based on fluorescence intensity, and transmission electron microscopy (TEM), employed to directly observe amyloid polypeptides, were used to evaluate the activity. The results showed that catechol-containing compounds 1–6 exhibited Aβ/hIAPP anti-aggregation and disaggregation activities, while compound 7, without catechol, showed no activity. This suggests that the presence of catechol is important for both activities. Daily intake of foods containing A-type procyanidins may be effective in the prevention and treatment of both diseases.

Saturn’s Rings

Saturn’s rings are not only a beautiful and enduring symbol of space, but astronomers’ best local laboratory for studying phenomena in thin cosmic disks like those where planets formed. All the giant planets have ring systems. Saturn’s are the biggest and brightest. Saturn’s rings are made of innumerable icy particles, ranging from the size of dust to that of football stadiums. Galileo discovered Saturn’s rings with his newly invented telescope, but they were not explained until Huygens described them as thin, flat disks surrounding the planet. In the space age, rings were found around the other giant planets in our solar system. Rings have been seen around asteroids and likely exist around exoplanets. Many of the ring structures seen are created by gravity from Saturn’s moons. Rings show both ongoing aggregation and disaggregation. After decades of study from space and by theoretical analysis, some puzzles still remain unexplained. There is evidence for youthful rings from Cassini results, but no good theory to explain their recent origin. A future Saturn Ring Observer mission would be able to determine the direct connections between the individual ring physical properties and the origin and evolution of larger structures.

The Consciousness Field

This article attempts to theoretically outline the nature and origins of the consciousness field in Paul C. Mocombe’s theory of phenomenological structuralism (PS). The author posits that consciousness is an emergent force of the universe that is received by the brain and integrated by its electromagnetic field to constitute mind, practical consciousness, and the self in material worlds of the multiverse. As such, the consciousness field, once assimilated in the absolute vacuum, is an interconnected, endless, and nonlocal fifth force of nature, which, initially, emerges following matter aggregation and disaggregation in the multiverse. It (the consciousness field) is an endless assimilation of all past, present, and future information (practical activities and memories) of the multiverse recycled via the absolute vacuum (empty space in which elementary particles, quarks, and constituents of matter and forces of nature have become one), which fluctuates as probability wave functions, to give rise to entangled and superimposed worlds, each with their own consciousness fields, with conscious beings.

Analysis of added value in bovines sold for the angus meat program in the south of Brazil

The objective of this work was to analyze price aggregation and disaggregation in commercialized animals searching for "Programa Carne Angus" benefits in the state of Rio Grande do Sul, Brazil. Data from 40,698 carcasses with Angus cattle racial pattern, slaughtered in a meat industry that performs the "Programa Carne Angus "certification, during the 2014 year were analyzed. The aggregated value was calculated by the difference between the negotiated base price for the lot and the final price obtained by animal after the certification process. The disaggregation was calculated based on the factors preventing the animals from being included in the certification program. The results show that the major disqualifying factor in males with the racial pattern was carcass fatness, and for females was the dentition, which disqualified 34.3 and 12.7% respectively. Value breakdown from 7,177 disqualified animals due to lack of finishing, or advanced dentition, reached R$ 1,213,528.00, or US$ 369,077.86 (US$ 51.43 per head), an amount that is no paid on from the industry to rural producers.Keywords: Aberdeen Angus, beef cattle dentition, beef cattle meat chain, fatness carcass, quality meat.