Biomedical Applications of Gold Nanoparticles Functionalized Using Hetero-Bifunctional Poly(ethylene glycol) Spacer

2004 ◽  
Vol 845 ◽  
Author(s):  
Wei Fu ◽  
Dinesh Shenoy ◽  
Jane Li ◽  
Curtis Crasto ◽  
Graham Jones ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Functional Group ◽  
Thiol Group ◽  
Poly Ethylene Glycol ◽  
Surface Attachment ◽  
Quenching Effect ◽  
Reactive Functional Group ◽  
Poly Ethylene

ABSTRACTTo increase the targeting potential, circulation time, and the flexibility of surface-attached biomedically-relevant ligands on gold nanoparticles, hetero-bifunctional poly(ethylene glycol) (PEG, MW 1, 500) was synthesized having a thiol group on one terminus and a reactive functional group on the other. Coumarin, a model fluorescent dye, was conjugated to the PEG spacer and gold nanoparticles were modified with coumarin-PEG-thiol. Surface attachment of coumarin through the PEG spacer decreases the fluorescence quenching effect of gold nanoparticles. The results of cellular cytotoxicity and fluorescence confocal analyses showed that the PEG spacer modified nanoparticles were essentially non-toxic and could be efficiently internalized in the cells within one hour of incubation.

Preparation and characterization of poly (ethylene glycol) grafted Ca-alginate fibers by γ-irradiation for biomedical applications

2013 ◽  
Vol 27 (2) ◽  
pp. 216-226 ◽  
Author(s):  
Md. Kamal Khan ◽  
Mohammed Mizanur Rahman ◽  
Bodrun Nesa ◽  
Romana Nasrin ◽  
Swajal Molla ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Poly Ethylene Glycol ◽  
Γ Irradiation ◽  
Alginate Fibers ◽  
Poly Ethylene ◽  
Ca Alginate

Transdermal delivery of poly(ethylene glycol)-co-oleylamine modified gold nanoparticles: Effect of size and shape

2019 ◽  
Vol 224 ◽  
pp. 22-28 ◽  
Author(s):  
Pa Fan Hsiao ◽  
Hsieh-Chih Tsai ◽  
Sydney Peng ◽  
Adhimoorthy Prasannan ◽  
Ting-Cheng Tang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Ethylene Glycol ◽  
Transdermal Delivery ◽  
Poly Ethylene Glycol ◽  
Size And Shape ◽  
Poly Ethylene

Poly(γ-glutamic acid) modulates the properties of poly(ethylene glycol) hydrogel for biomedical applications

2016 ◽  
Vol 27 (18) ◽  
pp. 1775-1787 ◽  
Author(s):  
Weikang Hu ◽  
Xiaoreng Feng ◽  
Xin Liu ◽  
Shulin Dai ◽  
Wen Zeng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Biomedical Applications ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol)

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Yubo Wang ◽  
Jose Enrico Q. Quinsaat ◽  
Tomoko Ono ◽  
Masatoshi Maeki ◽  
Manabu Tokeshi ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Ethylene Glycol ◽  
Dispersion Stability ◽  
Chemical Inhomogeneity ◽  
Poly Ethylene Glycol ◽  
Alternative Approach ◽  
Ft Ir ◽  
Poly Ethylene ◽  
Tumor Accumulation ◽  
Key Techniques

AbstractNano-sized metal particles are attracting much interest in industrial and biomedical applications due to the recent progress and development of nanotechnology, and the surface-modifications by appropriate polymers are key techniques to stably express their characteristics. Herein, we applied cyclic poly(ethylene glycol) (c-PEG), having no chemical inhomogeneity, to provide a polymer topology-dependent stabilization for the surface-modification of gold nanoparticles (AuNPs) through physisorption. By simply mixing c-PEG, but not linear counterparts, enables AuNPs to maintain dispersibility through freezing, lyophilization, or heating. Surprisingly, c-PEG endowed AuNPs with even better dispersion stability than thiolated PEG (HS–PEG–OMe). The stronger affinity of c-PEG was confirmed by DLS, ζ-potential, and FT-IR. Furthermore, the c-PEG system exhibited prolonged blood circulation and enhanced tumor accumulation in mice. Our data suggests that c-PEG induces physisorption on AuNPs, supplying sufficient stability toward bio-medical applications, and would be an alternative approach to the gold–sulfur chemisorption.

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