2021 ◽  
Author(s):  
Md Khairul Islam ◽  
Md Al Amin ◽  
Md Rakibul Islam ◽  
Md Nosin Ibna Mahbub ◽  
Md Imran Hossain Showrov ◽  
...  

Communication through email plays an essential part especially in every sector of our day-to-day life. Considering its significance, it is important to filter spam emails from emails. Spam email, also known as junk email, is unwanted messages that are sent by the electronic medium in large quantities. Most of the spam emails are commercial in nature that is not only irritating but also harmful due to malicious scams or malware-hosting sites or use viruses attached to the message. In this paper, we identify spam emails and expose how spam emails can be distinguished from legitimate/normal emails. We deployed four machine learning models and two deep learning models over the datasets including the combined dataset. Besides, we also try to find the important keywords that are found repeatedly from spam emails repository. This type of knowledge will enable us to detect spam emails for our personnel and community security purpose.<br>


2021 ◽  
Author(s):  
Md Khairul Islam ◽  
Md Al Amin ◽  
Md Rakibul Islam ◽  
Md Nosin Ibna Mahbub ◽  
Md Imran Hossain Showrov ◽  
...  

Communication through email plays an essential part especially in every sector of our day-to-day life. Considering its significance, it is important to filter spam emails from emails. Spam email, also known as junk email, is unwanted messages that are sent by the electronic medium in large quantities. Most of the spam emails are commercial in nature that is not only irritating but also harmful due to malicious scams or malware-hosting sites or use viruses attached to the message. In this paper, we identify spam emails and expose how spam emails can be distinguished from legitimate/normal emails. We deployed four machine learning models and two deep learning models over the datasets including the combined dataset. Besides, we also try to find the important keywords that are found repeatedly from spam emails repository. This type of knowledge will enable us to detect spam emails for our personnel and community security purpose.<br>


2021 ◽  
Author(s):  
Md Khairul Islam ◽  
Md Al Amin ◽  
Md Rakibul Islam ◽  
Md Nosin Ibna Mahbub ◽  
Md Imran Hossain Showrov ◽  
...  

Communication through email plays an essential part especially in every sector of our day-to-day life. Considering its significance, it is important to filter spam emails from emails. Spam email, also known as junk email, is unwanted messages that are sent by the electronic medium in large quantities. Most of the spam emails are commercial in nature that is not only irritating but also harmful due to malicious scams or malware-hosting sites or use viruses attached to the message. In this paper, we identify spam emails and expose how spam emails can be distinguished from legitimate/normal emails. We deployed four machine learning models and two deep learning models over the datasets including the combined dataset. Besides, we also try to find the important keywords that are found repeatedly from spam emails repository. This type of knowledge will enable us to detect spam emails for our personnel and community security purpose.<br>


2021 ◽  
Vol 422 ◽  
pp. 245-262
Author(s):  
Anh-Tu Tran ◽  
The-Dung Luong ◽  
Jessada Karnjana ◽  
Van-Nam Huynh

2020 ◽  
Author(s):  
Dean Sumner ◽  
Jiazhen He ◽  
Amol Thakkar ◽  
Ola Engkvist ◽  
Esben Jannik Bjerrum

<p>SMILES randomization, a form of data augmentation, has previously been shown to increase the performance of deep learning models compared to non-augmented baselines. Here, we propose a novel data augmentation method we call “Levenshtein augmentation” which considers local SMILES sub-sequence similarity between reactants and their respective products when creating training pairs. The performance of Levenshtein augmentation was tested using two state of the art models - transformer and sequence-to-sequence based recurrent neural networks with attention. Levenshtein augmentation demonstrated an increase performance over non-augmented, and conventionally SMILES randomization augmented data when used for training of baseline models. Furthermore, Levenshtein augmentation seemingly results in what we define as <i>attentional gain </i>– an enhancement in the pattern recognition capabilities of the underlying network to molecular motifs.</p>


2019 ◽  
Author(s):  
Mohammad Rezaei ◽  
Yanjun Li ◽  
Xiaolin Li ◽  
Chenglong Li

<b>Introduction:</b> The ability to discriminate among ligands binding to the same protein target in terms of their relative binding affinity lies at the heart of structure-based drug design. Any improvement in the accuracy and reliability of binding affinity prediction methods decreases the discrepancy between experimental and computational results.<br><b>Objectives:</b> The primary objectives were to find the most relevant features affecting binding affinity prediction, least use of manual feature engineering, and improving the reliability of binding affinity prediction using efficient deep learning models by tuning the model hyperparameters.<br><b>Methods:</b> The binding site of target proteins was represented as a grid box around their bound ligand. Both binary and distance-dependent occupancies were examined for how an atom affects its neighbor voxels in this grid. A combination of different features including ANOLEA, ligand elements, and Arpeggio atom types were used to represent the input. An efficient convolutional neural network (CNN) architecture, DeepAtom, was developed, trained and tested on the PDBbind v2016 dataset. Additionally an extended benchmark dataset was compiled to train and evaluate the models.<br><b>Results: </b>The best DeepAtom model showed an improved accuracy in the binding affinity prediction on PDBbind core subset (Pearson’s R=0.83) and is better than the recent state-of-the-art models in this field. In addition when the DeepAtom model was trained on our proposed benchmark dataset, it yields higher correlation compared to the baseline which confirms the value of our model.<br><b>Conclusions:</b> The promising results for the predicted binding affinities is expected to pave the way for embedding deep learning models in virtual screening and rational drug design fields.


2020 ◽  
Author(s):  
Saeed Nosratabadi ◽  
Amir Mosavi ◽  
Puhong Duan ◽  
Pedram Ghamisi ◽  
Ferdinand Filip ◽  
...  

This paper provides a state-of-the-art investigation of advances in data science in emerging economic applications. The analysis was performed on novel data science methods in four individual classes of deep learning models, hybrid deep learning models, hybrid machine learning, and ensemble models. Application domains include a wide and diverse range of economics research from the stock market, marketing, and e-commerce to corporate banking and cryptocurrency. Prisma method, a systematic literature review methodology, was used to ensure the quality of the survey. The findings reveal that the trends follow the advancement of hybrid models, which, based on the accuracy metric, outperform other learning algorithms. It is further expected that the trends will converge toward the advancements of sophisticated hybrid deep learning models.


Author(s):  
Yuejun Liu ◽  
Yifei Xu ◽  
Xiangzheng Meng ◽  
Xuguang Wang ◽  
Tianxu Bai

Background: Medical imaging plays an important role in the diagnosis of thyroid diseases. In the field of machine learning, multiple dimensional deep learning algorithms are widely used in image classification and recognition, and have achieved great success. Objective: The method based on multiple dimensional deep learning is employed for the auxiliary diagnosis of thyroid diseases based on SPECT images. The performances of different deep learning models are evaluated and compared. Methods: Thyroid SPECT images are collected with three types, they are hyperthyroidism, normal and hypothyroidism. In the pre-processing, the region of interest of thyroid is segmented and the amount of data sample is expanded. Four CNN models, including CNN, Inception, VGG16 and RNN, are used to evaluate deep learning methods. Results: Deep learning based methods have good classification performance, the accuracy is 92.9%-96.2%, AUC is 97.8%-99.6%. VGG16 model has the best performance, the accuracy is 96.2% and AUC is 99.6%. Especially, the VGG16 model with a changing learning rate works best. Conclusion: The standard CNN, Inception, VGG16, and RNN four deep learning models are efficient for the classification of thyroid diseases with SPECT images. The accuracy of the assisted diagnostic method based on deep learning is higher than that of other methods reported in the literature.


2020 ◽  
Vol 15 ◽  
Author(s):  
Deeksha Saxena ◽  
Mohammed Haris Siddiqui ◽  
Rajnish Kumar

Background: Deep learning (DL) is an Artificial neural network-driven framework with multiple levels of representation for which non-linear modules combined in such a way that the levels of representation can be enhanced from lower to a much abstract level. Though DL is used widely in almost every field, it has largely brought a breakthrough in biological sciences as it is used in disease diagnosis and clinical trials. DL can be clubbed with machine learning, but at times both are used individually as well. DL seems to be a better platform than machine learning as the former does not require an intermediate feature extraction and works well with larger datasets. DL is one of the most discussed fields among the scientists and researchers these days for diagnosing and solving various biological problems. However, deep learning models need some improvisation and experimental validations to be more productive. Objective: To review the available DL models and datasets that are used in disease diagnosis. Methods: Available DL models and their applications in disease diagnosis were reviewed discussed and tabulated. Types of datasets and some of the popular disease related data sources for DL were highlighted. Results: We have analyzed the frequently used DL methods, data types and discussed some of the recent deep learning models used for solving different biological problems. Conclusion: The review presents useful insights about DL methods, data types, selection of DL models for the disease diagnosis.


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