scholarly journals Determination of Agmatine Rate by Spectrofluorimetric Method in Alkaline Medium: Optimization and Application on Shrimp.

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Khémesse Kital ◽  
Moumouny Traoré ◽  
Diégane Sarr ◽  
Moussa Mbaye ◽  
Olivier Mbaye ◽  
...  
Keyword(s):  
Alkaline Medium ◽  
Medium Optimization ◽  
Spectrofluorimetric Method

scholarly journals Second derivative synchronous fluorescence determination of avanafil in the presence of its acid-induced degradation product aided by powerful Lean Six Sigma tools augmented with D-optimal design

RSC Advances ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 3834-3842
Author(s):  
Khalid A. M. Attia ◽  
Ahmad A. Mohamad ◽  
Mohamed S. Emara ◽  
Ahmed M. Abdel-Raoof ◽  
Mohamed A. Hasan ◽  
...  
Keyword(s):  
Optimal Design ◽  
Quantitative Determination ◽  
Degradation Product ◽  
Six Sigma ◽  
Lean Six Sigma ◽  
Synchronous Fluorescence ◽  
Second Derivative ◽  
Fluorescence Determination ◽  
Spectrofluorimetric Method

In this work, the quantitative determination of an erectile dysfunctional drug avanafil in the presence of its acid-induced degradation product was achieved via the application of a pre-optimized novel spectrofluorimetric method.

Simultaneous determination of amlodipine and metoprolol in their combined dosage form using a synchronous fluorescence spectrofluorimetric method

Luminescence ◽  
2017 ◽  
Vol 33 (2) ◽  
pp. 364-369 ◽  
Author(s):  
Mokhtar M. Mabrouk ◽  
Sherin F. Hammad ◽  
Samah F. El-Malla ◽  
Eman A. Elshenawy
Keyword(s):  
Simultaneous Determination ◽  
Dosage Form ◽  
Synchronous Fluorescence ◽  
Spectrofluorimetric Method

scholarly journals Erratum to: A Simple Spectrofluorimetric Method for the Determination of Losartan in Some Tablet Dosage Forms

2016 ◽  
Vol 82 (6) ◽  
pp. 1078-1078
Author(s):  
M. A. Taher ◽  
H. Asadollahzadeh ◽  
H. Fazelirad
Keyword(s):  
Dosage Forms ◽  
Spectrofluorimetric Method ◽  
Tablet Dosage

Spectrofluorimetric Method for the Determination of Trimethoprim in Body Fluids

Chemotherapy ◽  
1969 ◽  
Vol 14 (1) ◽  
pp. 22-29 ◽  
Author(s):  
D.E. Schwartz ◽  
B.A. Koechlin ◽  
R.E. Weinfeld
Keyword(s):  
Body Fluids ◽  
Spectrofluorimetric Method

scholarly journals DIRECT SPECTROPHOTOMETRIC DETERMINATION OF ATENOLOL AND TIMOLOL ANTI-HYPERTENSIVE DRUGS

2017 ◽  
Vol 9 (3) ◽  
pp. 47 ◽  
Author(s):  
Akram M. El-didamony ◽  
Moftah A. Moustafa
Keyword(s):  
Alkaline Medium ◽  
Initial Rate ◽  
Fixed Time ◽  
Dosage Forms ◽  
Green Product ◽  
Bluish Green ◽  
Experimental Parameters ◽  
Calibration Equations ◽  
Sensitive Spectrophotometric Method

Objective: Direct and sensitive spectrophotometric method is described for the quantitative determination of some anti-hypertensive drugs such as atenolol (ATN) and timolol (TIM) in pure forms as well as in their dosage forms.Methods: The proposed method is based on the redox reaction between the selected drugs and KMnO4 in alkaline medium. The method involves treating the aqueous solution of the selected drugs with KMnO4 in alkaline medium and measuring the bluish-green product at 610 nm. The different experimental parameters affecting the development and stability of the color were carefully studied and optimized.Results: The fixed-time method is adopted for constructing the calibration curves, which were found to be linear over the concentration ranges of 2.0–14 mg/ml and 2.0–28 mg/ml for ATN and TIM, respectively. The determination of the studied drugs by initial rate, variable time and rate constant method was workable with the calibration equations obtained but the fixed time method has been found to be more applicable.Conclusion: The applicability of the proposed method was demonstrated by the determination of the selected drugs in both pure and in commercial dosage forms and has met the validation requirements.

scholarly journals New Spectrofluorimetric Method with Enhanced Sensitivity for Determination of Paroxetine in Dosage Forms and Plasma

2008 ◽  
Vol 3 ◽  
pp. ACI.S1053 ◽  
Author(s):  
Ibrahim A. Darwish ◽  
Sawsan M. Amer ◽  
Heba H. Abdine ◽  
Lama I. Al-Rayes
Keyword(s):  
High Sensitivity ◽  
Dosage Forms ◽  
Official Method ◽  
Factors Affecting ◽  
Pharmaceutical Tablets ◽  
Enhanced Sensitivity ◽  
Spectrofluorimetric Method ◽  
Relative Standard ◽  
Optimized Conditions

New simple spectrofluorimetric method with enhanced sensitivity has been developed and validated for the determination of the antidepressant paroxetine (PXT) in its dosage forms and plasma. The method was based on nucleophilic substitution reaction of PXT with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole in an alkaline medium (pH 8) to form a highly fluorescent derivative that was measured at 545 nm after excitation at 490 nm. The factors affecting the reaction was carefully studied and optimized. The kinetics of the reaction was investigated, and the reaction mechanism was presented. Under the optimized conditions, linear relationship with good correlation coefficient (0.9993) was found between the fluorescence intensity and PXT concentration in the range of 80-800 ng ml-1. The limits of detection and quantitation for the method were 25 and 77 ng ml-1, respectively. The precision of the method was satisfactory; the values of relative standard deviations did not exceed 3%. The proposed method was successfully applied to the determination of PXT in its pharmaceutical tablets with good accuracy; the recovery values were 100.2 ± 1.61%. The results obtained by the proposed method were comparable with those obtained by the official method. The proposed method is superior to the previously reported spectrofluorimetric method for determination of PXT in terms of its higher sensitivity and wider linear range. The high sensitivity of the method allowed its successful application to the analysis of PXT in spiked human plasma. The proposed method is practical and valuable for its routine application in quality control and clinical laboratories for analysis of PXT.

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