scholarly journals Comparative evaluation of polymethylmethacrylate and composite bone cements. Review of the experimental studies results

2021 ◽  
pp. 86-91
Author(s):  
Oleg Vyrva ◽  
Olexii Goncharuk ◽  
Natalia Lysenko
Keyword(s):  
Bone Cement ◽  
Bone Tissue ◽  
Experimental Studies ◽  
Bone Cements ◽  
Main Task ◽  
Composite Cement ◽  
Bone Fragments ◽  
Intensive Work ◽  
Composite Bone

Current article is a review of experimental studies of different bone cements types and their combinations. Providing of bone fragments  stable fixation  at osteosynthesis  in cases of difficult multifragmental fractures, arthroplasties and other implants using especially in the osteoporosis conditions is a main task of orthopaedic surgery procedures. Polymethylmethacrylate (PMMA) is the first material that is answered to these requirements. The evolution of bone cements resulted in creation of a new composite substance — combination of PMMA and β-threecalciumphosfates (β-TCPh). Combination of these two components allowed to provide high bioabsorbal, osteoconductive and osteointegrative properties along with sufficient durability. In the analyzed works the properties of composite cement CalCemex were evaluated in vivo experiment. It was found that in the case of PMMA penetration of bone tissue into the polymer structure did not occur. Under the conditions of using bone cement with β-TCF admixture, the formation of bone tissue was observed not only on the surface of the implant, but also in the external and internal pores. It is the presence of pores in CalCemex that the authors explain the possibility of penetration of cellular elements, blood vessels and bone formation. Moreover, β-TCPh is included into this material and it is bioresorbed by osteoclasts. This leads to the release of calcium and phosphorus ions and, consequently, simplifies the attachment of the newly formed bone to the bone cement. We assume that composite cement like CalCemex type is a promising material for the treatment of various types of fractures and replacement of bone defects. It should be mentioned that research in this area is ongoing and intensive work is underway to synthesize and study the results of clinical application of composite bone cements with maximum bioactive properties that will not only strengthen bone tissue but also perform osteointegrative function. Key words. Bone cement, polymethylmethacrylate, β-threecalciumphosfates, experiment.

scholarly journals Preliminary in Vivo Evaluation of Bone Healing in Critical Size Bone Defects Implanted with an Injectable Calcium Phosphate Bone Cement (Osteopaste)

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Che Nor Zarida Che Seman ◽  
Zamzuri Zakaria ◽  
Zunariah Buyong ◽  
Mohd Shukrimi Awang ◽  
Ahmad Razali Md Ralib @ Md Raghib
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Bone Tissue ◽  
Bone Repair ◽  
Critical Size ◽  
Healing Process ◽  
Bone Defects ◽  
Calcium Phosphate Bone Cement ◽  
Rabbit Tibia

Introduction: A novel injectable calcium phosphate bone cement (osteopaste) has been developed. Its potential application in orthopaedics as a filler of bone defects has been studied. The biomaterial was composed of tetra-calcium phosphate (TTCP) and tricalcium phosphate (TCP) powder. The aim of the present study was to evaluate the healing process of osteopaste in rabbit tibia. Materials and method: The implantation procedure was carried out on thirty-nine of New Zealand white rabbits. The in vivo bone formation was investigated by either implanting the Osteopaste, Jectos or MIIG – X3 into a critical size defect (CSD) model in the proximal tibial metaphysis. CSD without treatment served as negative control. After 1 day, 6 and 12 weeks, the rabbits were euthanized, the bone were harvested and subjected for analysis. Results: Radiological images and histological sections revealed integration of implants with bone tissue with no signs of graft rejection. There was direct contact between osteopaste material and host bone. The new bone was seen bridging the defect. Conclusion: The result showed that Osteopaste could be a new promising biomaterial for bone repair and has a potential in bone tissue engineering.

scholarly journals Loading necrostatin-1 composite bone cement inhibits necroptosis of bone tissue in rabbit

2019 ◽  
Vol 6 (2) ◽  
pp. 113-119 ◽  
Author(s):  
Xiang Ji ◽  
Feng Xu ◽  
Guoling Dong ◽  
Chongzhe Jia ◽  
Pu Jia ◽  
...  
Keyword(s):  
Bone Cement ◽  
Bone Tissue ◽  
Composite Bone

Preparation and in vivo evaluation of a silicate-based composite bone cement

2017 ◽  
Vol 32 (2) ◽  
pp. 257-264 ◽  
Author(s):  
Bing Ma ◽  
Zhiguang Huan ◽  
Chen Xu ◽  
Nan Ma ◽  
Haibo Zhu ◽  
...  
Keyword(s):  
Bone Cement ◽  
In Vivo Evaluation ◽  
Composite Bone

scholarly journals A promising material for bone repair: PMMA bone cement modified by dopamine-coated strontium-doped calcium polyphosphate particles

2019 ◽  
Vol 6 (10) ◽  
pp. 191028 ◽  
Author(s):  
Xing Liu ◽  
Can Cheng ◽  
Xu Peng ◽  
Hong Xiao ◽  
Chengrui Guo ◽  
...  
Keyword(s):  
Bone Cement ◽  
Bone Repair ◽  
Bone Cements ◽  
The Novel ◽  
Calcium Polyphosphate ◽  
Pmma Bone Cement ◽  
Repair Materials ◽  
Biological Performance ◽  
Bone Repair Materials ◽  
Composite Bone

Polymethyl methacrylate (PMMA) bone cement has been widely used in clinics as bone repair materials for its excellent mechanical properties and good injection properties. However, it also has defects such as poor biological performance, high temperature, and the monomer has certain toxicity. Our study tried to modify the PMMA bone cement by doping with various particle weight fractions (5, 10 and 15%) of SCPP particles and polydopamine-coated SCPP particles (D/SCPP) to overcome its clinical application disadvantages. Our study showed that all results of physical properties of samples are in accordance with ISO 5833. The 15% D/SCPP/PMMA composite bone cement had much better biocompatibility compared with pure PMMA bone cement and SCPP/PMMA composite bone cement due to the best cell growth-promoting mineralization deposition on the surface of 15% D/SCPP/PMMA composite bone cements and Sr 2+ released from SCPP particles. Our research also revealed that the reaction temperature was found to be reduced with an increase in doped particles after incorporating the particles into composite bone cements. The novel PMMA bone cements modified by D/SCPP particles are promising materials for bone repair.

In vivo histologic and biomechanical characterization of a biodegradable particulate composite bone cement

1989 ◽  
Vol 23 (1) ◽  
pp. 1-16 ◽  
Author(s):  
Tobin N. Gerhart ◽  
Andrew A. Renshaw ◽  
Richard L. Miller ◽  
Robert J. Noecker ◽  
Wilson C. Hayes
Keyword(s):  
Bone Cement ◽  
Particulate Composite ◽  
Composite Bone

Silicate bioceramic/PMMA composite bone cement with distinctive physicochemical and bioactive properties

RSC Advances ◽  
2015 ◽  
Vol 5 (47) ◽  
pp. 37314-37322 ◽  
Author(s):  
Lei Chen ◽  
Dong Zhai ◽  
Zhiguang Huan ◽  
Nan Ma ◽  
Haibo Zhu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Mechanical Strength ◽  
Bone Regeneration ◽  
Bone Cement ◽  
Bone Cements ◽  
High Mechanical Strength ◽  
Bioactive Properties ◽  
Composite Bone

New bioactive silicate/PMMA composite bone cements possess improved setting properties, high mechanical strength, excellent apatite-mineralization ability and biological activity for injectable bone regeneration materials application.

scholarly journals Oxidatively degradable poly(thioketal urethane)/ceramic composite bone cements with bone-like strength

RSC Advances ◽  
2016 ◽  
Vol 6 (111) ◽  
pp. 109414-109424 ◽  
Author(s):  
Madison A. P. McEnery ◽  
Sichang Lu ◽  
Mukesh K. Gupta ◽  
Katarzyna J. Zienkiewicz ◽  
Joseph C. Wenke ◽  
...  
Keyword(s):  
Ceramic Composite ◽  
Bone Cements ◽  
Composite Bone

Oxidatively degradable bone cements exhibit bone-like strength and remodel to form new bone in vivo.

In vitro and in vivo effectiveness of a novel injectable calcitonin-loaded collagen/ceramic bone substitute

2021 ◽  
pp. 088532822198998
Author(s):  
Karl Wu ◽  
Yu-Chun Chen ◽  
Shang M Lin ◽  
Chih-Hung Chang
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Degradation Rate ◽  
Rabbit Model ◽  
Type I ◽  
Calcium Phosphate Bone Cement ◽  
Osteogenic Effect ◽  
Composite Bone

This study aimed to evaluate the effectiveness of a novel calcitonin-loaded calcium phosphate composite bone cement in vitro and in vivo. The novel composite bone cements were composed of NuROs injectable bone graft substitute, type I collagen, and/or salmon calcitonin. The setting time, porosity, wettability, compressive strength, compressive modulus, and crystallographic structures of cement specimens were determined. Degradation rate, calcitonin release rate, and osteoinductivity were assessed in vitro. In addition, osteogenic effect was examined in a rabbit model of femoral defect. The results revealed that addition of collagen/calcitonin did not substantially alter physical properties and degradation rate of bone cement specimens. Calcitonin was released into culture medium in a two-phase manner. Osteogenic effect of conditioned medium derived from calcitonin containing bone cement was observed. Finally, de novo bone growth and bone mineralization across the bone defect area were observed in rabbits after implantation of composite bone cement specimens. In conclusion, this novel calcitonin-loaded composite calcium phosphate bone cement exhibits biocompatibility, bioresorbability, osteoinductivity, and osteoconductivity, which may be suitable for clinical use.

In-Vivo Degradation of a Poly(Propylene-Fumarate) Biodegradable, Particulate Composite Bone Cement

1995 ◽  
Vol 394 ◽  
Author(s):  
Daveed D. Frazier ◽  
Vijay K. Lathi ◽  
Tobin N. Gerhart ◽  
David E. Altobelli ◽  
Wilson C. Hayes
Keyword(s):  
Bone Cement ◽  
Ex Vivo ◽  
Particulate Composite ◽  
Structural Reinforcement ◽  
Age Related ◽  
Poly Propylene ◽  
Osseous Defects ◽  
Sufficient Strength ◽  
Composite Bone

AbstractWe have developed a biodegradable particulate composite bone cement consisting of a poly(propylene glycol-fumarate)-(methylmethacrylate) matrix mixed with calcium carbonate and tricalcium phosphate particulates. Previous ex-vivo studies suggest that this system provides sufficient strength for a number of potential clinical applications including structural reinforcement of osseous defects, supplementation of internal fixation of age-related fractures, and delivery of antibiotics to treat osteomyelitis. Ex-vivo degradation assays have also shown that the cement approximates physiologic conditions of bone remodeling as it degrades. In order to evaluate the in-vivo responses to this material, we implanted cement specimens subcutaneously in rats for up to 84 days. Compressive strength of the subcutaneous implants increased linearly through day 21 to 4.91 MPa, then decreased linearly by day 84 to less than 1 MPa. We conclude that this PPFMMA system is biocompatible and biodegradable, and has the potential for use as an orthopedic bone cement. Future studies will be directed toward characterizing the intraosseous histological response and at coordinating the rate of cement degradation with bony ingrowth.

Sign in / Sign up

Export Citation Format

Share Document