Specific parameters of lipid spectrum and markers of vascular inflammation in patients with stable angina and significant coronary artery stenosis with or without diabetes mellitus type 2. A prospective follow-up after angioplasty

The article deals with the evaluation of comprehensive and segmental systolic deformation of the myocardium by the method of speckle tracking echocardiography in patients with the stable angina pectoris of II and III functional class accompanied by diabetes mellitus type 2 and in patients with isolated stable angina pectoris and isolated diabetes mellitus type 2. This study resulted in the evaluation of the comprehensive and segmental systolic myocardium deformation indicators diagnostic utility, the indication of threshold levels for the diagnosis of comprehensive and segmental systolic deformation of myocardium caused by coronary atherosclerosis in patients.

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Lipid profile and markers of vascular inflammation in patients with stable angina in the presence and absence of type 2 diabetes mellitus

Diabetes Mellitus ◽

10.14341/7959 ◽

2017 ◽

Vol 20 (3) ◽

pp. 194-200 ◽

Cited By ~ 1

Author(s):

Tatiana I. Petelina ◽

Natalia A. Musikhina ◽

Liudmila I. Gapom ◽

Irina V. Емеneva ◽

Elena A. Gorbatenko

Keyword(s):

Diabetes Mellitus ◽

Lipid Profile ◽

Stable Angina ◽

Inflammatory Markers ◽

Vascular Inflammation ◽

Increased Risk ◽

Presence And Absence ◽

Group 2 ◽

Group 1

Background. The mechanisms underlying the close relationship between diabetes mellitus (DM) and coronary artery disease (CAD) have not been fully understood. The pathophysiological processes of vascular inflammation that accelerate and enhance the development of atherosclerotic vascular lesions and their complications warrant further study. Aims. To compare lipid profiles and inflammatory markers in patients with CAD and stable angina in the presence and absence of type 2 DM. Materials and methods. A total of 169 patients were examined: Group 1 included 123 patients with CAD but without DM; Group 2 consisted of 46 patients with CAD and DM. The biochemical parameters were estimated before coronary angiography. Results. The lipid profile in both groups of patients revealed elevated levels of atherogenic markers (TС, LDL, VLDLP and TG). Patients in Group 2 had significantly increased levels of vascular inflammatory markers (hs-CRP, homocysteine, IL-1), TNF-, MMP-9 and endothelin-1 compared to those in Group 1. Conclusions. Our results indicate that the vascular inflammatory response was more pronounced in patients with CAD and DM and that they have an increased risk of developing adverse vascular complications.

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ROLE OF HYPERCORTISOLEMIA IN PROGRESSION OF THE COMORBID COURSE OF CORONARY ARTERY DISEASE, DIABETES MELLITUS TYPE 2 AND ANEMIA

CBU International Conference Proceedings ◽

10.12955/cbup.v7.1457 ◽

2019 ◽

Vol 7 ◽

pp. 794-797

Author(s):

Nataliia Pavliukovych ◽

Oleksandr Pavliukovych ◽

Oleksandr Buriak ◽

Tamara Kopchuk ◽

Volodymyr Vivsyannuk

Keyword(s):

Diabetes Mellitus ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Diabetes Mellitus Type 2 ◽

Chronic Hypoxia ◽

Diabetes Mellitus Type ◽

Control Group ◽

Artery Disease ◽

Degree Of Severity

INTRODUCTION: Hyperactivation of stress-limiting mechanisms of the organism is a unique physiological response of the human being to chronic hypoxia of different origins. OBJECTIVES: Investigation of dynamics of cortisol synthesis changes in patients with coronary artery disease with comorbid diabetes mellitus type 2 and anemic syndrome in patients of older age groups. METHODS: Blood cortisol level was measured in 40 old and senile coronary artery disease patients with comorbid diabetes mellitus type 2 and anemic syndrome of different degrees of severity. The control group consisted of 12 patients with coronary artery disease without comorbidities that were not significantly different through gender and age from the patients of the research groups. Possible effects of telmisartan on the degree of chronic hypoxia were also investigated. RESULTS: In patients of old and senile age with coronary artery disease and comorbid anemic syndrome, same as in case of coronary artery disease and anemic syndrome on the background of diabetes mellitus type 2, activation of the cortisol synthesis is observed, likely in response to hypoxia as a stress factor in anemia. The degree of severity of the detected changes was different depending on the degree of anemia severity. There was no normalization of cortisol content in blood in any of the major experimental groups regardless the prescribed treatment with ACE inhibitors or telmisartan. CONCLUSIONS: In patients with coronary artery disease, same as in the case of a comorbid course of coronary artery disease and diabetes mellitus type 2, an increase of cortisol secretion in response to anemic hypoxia was observed. As the degree of severity of the anemic syndrome progressed, gradual decreasing of cortisol blood level was detected. Reduction of the intensity of stress-limiting systems in the organism by telmisartan prescription may help to eliminate the adverse effects of hypercortisolemia on the progression of coronary artery disease, especially on the background of comorbid diabetes mellitus type 2 and anemia.

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