scholarly journals The role of beta-blockers in the treatment of hypertension in 2018 ESC/ESH guidelines

2018 ◽  
pp. 96-99
Author(s):  
A. O. Konradi ◽  
L. G. Ratova ◽  
I. V. Emelyanov ◽  
A. O. Nedoshivin
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Arterial Hypertension ◽  
Beta Blockers ◽  
Cardiovascular Morbidity And Mortality ◽  
The World ◽  
Treatment Of Hypertension ◽  
Sympathetic Nervous ◽  
New Guidelines

Arterial hypertension (AH) is the most common non­infectious disease in the world and in Russia, associated with high cardiovascular morbidity and mortality. In August 2018, new guidelines for the diagnosis and treatment of patients with arterial hypertension were presented at the European Congress of Cardiology. The article discusses the role of the sympathetic nervous system in the pathogenesis of hypertension and the current importance of beta­blockers in the treatment of hypertension.

scholarly journals Pathophysiology of Resistant Hypertension: The Role of Sympathetic Nervous System

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Costas Tsioufis ◽  
Athanasios Kordalis ◽  
Dimitris Flessas ◽  
Ioannis Anastasopoulos ◽  
Dimitris Tsiachris ◽  
...  
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Resistant Hypertension ◽  
Antihypertensive Treatment ◽  
Treatment Options ◽  
Treatment Resistance ◽  
Obstructive Sleep ◽  
Cardiovascular Morbidity And Mortality ◽  
Sympathetic Nervous

Resistant hypertension (RH) is a powerful risk factor for cardiovascular morbidity and mortality. Among the characteristics of patients with RH, obesity, obstructive sleep apnea, and aldosterone excess are covering a great area of the mosaic of RH phenotype. Increased sympathetic nervous system (SNS) activity is present in all these underlying conditions, supporting its crucial role in the pathophysiology of antihypertensive treatment resistance. Current clinical and experimental knowledge points towards an impact of several factors on SNS activation, namely, insulin resistance, adipokines, endothelial dysfunction, cyclic intermittent hypoxaemia, aldosterone effects on central nervous system, chemoreceptors, and baroreceptors dysregulation. The further investigation and understanding of the mechanisms leading to SNS activation could reveal novel therapeutic targets and expand our treatment options in the challenging management of RH.

scholarly journals Central regulation of circulation and arterial hypertension

2006 ◽  
Vol 12 (1) ◽  
pp. 66-79
Author(s):  
V. A. Tsyrlin
Keyword(s):  
Nervous System ◽  
Essential Hypertension ◽  
Autonomic Nervous System ◽  
Sympathetic Nervous System ◽  
Arterial Hypertension ◽  
Central Regulation ◽  
Sympathetic Nervous System Activity ◽  
Nervous System Activity ◽  
Sympathetic Nervous

Modern concepts about role of autonomic nervous system central regulation disturbance in pathogenesis of arterial hypertension are analysed in this article. Also it is examined presented hypothesis. explaining the increase of sympathetic nervous system activity and depression of vagal nerve tonuson experimental pathology at animals and essential hypertension at human.

scholarly journals Role of the sympathetic nervous system in vasovagal syncope and rationale for beta-blockers and norepinephrine transporter inhibitors

Medwave ◽  
2016 ◽  
Vol 16 (Suppl4) ◽  
pp. e6824-e6824 ◽  
Author(s):  
Manlio F. Márquez ◽  
Jorge Rafael Gómez-Flores ◽  
Jesús A. González-Hermosillo ◽  
Teresita de Jesús Ruíz-Siller ◽  
Manuel Cárdenas
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Beta Blockers ◽  
Vasovagal Syncope ◽  
Norepinephrine Transporter ◽  
Sympathetic Nervous

scholarly journals The role of the vegetative part of sympathetic nervous system in development of cardiovascular complications in patients with arterial hypertension: pharmacological aspects

2014 ◽  
Vol 11 (3) ◽  
pp. 88-94
Author(s):  
S R Gilyarevsky
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Arterial Hypertension ◽  
Cardiovascular System ◽  
Antihypertensive Agents ◽  
Cardiovascular Complications ◽  
Autonomic Regulation ◽  
Sympathetic Nervous ◽  
The Impact

Recently, we have determined new interest in studying the role of sympathetic part of autonomic division of nervous system (SANS) in the pathogenesis of arterial hypertension (AH), as well as in studying the role of agents, suppressing the activity of SANS, using for AH treatment, including the usage of antihypertensive agents and non-pharmacological methods. This article discusses the changes of autonomic regulation of the cardiovascular system in patients with AH. The role of these changes in the development of the functional and structured changes of the heart and systemic vessels can be observing during long-standing AH and will lead to the development of adverse clinical outcomes. We have been showing received data, associated with the impact of non-medicated and pharmacological approaches to the autonomic regulation of the cardiovascular system.

Thyroid hormone-catecholamine interrelationships during exposure to cold

1981 ◽  
Vol 97 (1) ◽  
pp. 91-97 ◽  
Author(s):  
H. Storm ◽  
C. van Hardeveld ◽  
A. A. H. Kassenaar
Keyword(s):  
Nervous System ◽  
Plasma Concentration ◽  
Thyroid Hormone ◽  
Sympathetic Nervous System ◽  
Plasma Levels ◽  
Surgical Procedure ◽  
Exposure To Cold ◽  
Basal Plasma ◽  
Sympathetic Nervous

Abstract. Basal plasma levels for adrenalin (A), noradrenalin (NA), l-triiodothyronine (T3), and l-thyroxine (T4) were determined in rats with a chronically inserted catheter. The experiments described in this report were started 3 days after the surgical procedure when T3 and T4 levels had returned to normal. Basal levels for the catecholamines were reached already 4 h after the operation. The T3/T4 ratio in plasma was significantly increased after 3, 7, and 14 days in rats kept at 4°C and the same holds for the iodide in the 24-h urine after 7 and 14 days at 4°C. The venous NA plasma concentration was increased 6- to 12-fold during the same period of exposure to cold, whereas the A concentration remained at the basal level. During infusion of NA at 23°C the T3/T4 ratio in plasma was significantly increased after 7 days compared to pair-fed controls, and the same holds for the iodide excretion in the 24-h urine. This paper presents further evidence for a role of the sympathetic nervous system on T4 metabolism in rats at resting conditions.

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