scholarly journals INFLUENCE OF TORASEMIDE ON ELECTRICAL INSTABILITY OF THE HEART IN PATIENTS WITH ISCHEMIC MITRAL REGURGITATION POST MYOCARDIAL INFARCTION

2018 ◽  
pp. 43-48
Author(s):  
I. B. Ibragimova ◽  
U. A. Islamova ◽  
R. M. Gafurova ◽  
A. A. Abdullaev
Keyword(s):  
Myocardial Infarction ◽  
Mitral Regurgitation ◽  
Ischemic Mitral Regurgitation ◽  
Post Myocardial Infarction ◽  
Electrical Instability

scholarly journals Mitral valve leaflet response to ischemic mitral regurgitation: From gene expression to tissue remodeling

2019 ◽  
Author(s):  
Daniel P. Howsmon ◽  
Bruno V. Rego ◽  
Estibaliz Castillero ◽  
Salma Ayoub ◽  
Amir H. Khalighi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Myocardial Infarction ◽  
Extracellular Matrix ◽  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Rna Sequencing ◽  
Immune Cells ◽  
Ischemic Mitral Regurgitation ◽  
Post Myocardial Infarction ◽  
Mechanical Anisotropy

AbstractAimsIschemic mitral regurgitation is frequently observed following myocardial infarction and is associated with higher mortality and poor clinical prognosis if left untreated. Accumulating evidence suggests that mitral valve leaflets actively remodel post–myocardial infarction, yet the cellular mechanisms underlying these responses and how this affects tissue function remain largely unknown. We sought to elucidate mitral valve remodeling post myocardial infarction at the tissue, cellular, and transcriptomic levels.Methods and ResultsThe mechanical behavior of ovine mitral valve leaflets pre– and 8 weeks post– myocardial infarction reveal a significant decrease in radial direction extensibility, which essentially eliminated the mechanical anisotropy typically observed in healthy mitral valves. Quantitative histology and ultrastructural assessment by transmission electron microscopy revealed altered leaflet composition and architecture at 8 weeks post–myocardial infarction. Assessment of the mitral valve interstitial cell nuclear aspect ratio, a metric of cellular deformation, revealed that they were on average rounder following myocardial infarction. RNA sequencing indicated that YAP-induced genes were elevated at 4 weeks post–myocardial infarction and genes related to extracellular matrix organization were some of the most downregulated in sheep with IMR compared to sheep without ischemic mitral regurgitation at 4 weeks post–myocardial infarction. Additionally, RNA sequencing revealed the possible recruitment of immune cells in this remodeling process due to the drastic elevation of CXCL9 and CLEC10A.ConclusionsOur multiscale assessment revealed significant mechanical and microstructural changes due to myocardial infarction. RNA sequencing provided a baseline for global gene expression changes in response to myocardial infarction with and without ischemic mitral regurgitation and suggests YAP-induced mechanotransduction, altered expression of extracellular matrix–related genes, and recruitment of immune cells as mechanisms contributing to altered mitral valve biomechanics post–myocardial infarction.

scholarly journals Transventricular Mitral Valve Repair in Patients with Acute Forms of Ischemic Mitral Regurgitation

2014 ◽  
Vol 41 (3) ◽  
pp. 312-315 ◽  
Author(s):  
Kerim Cagli ◽  
Hikmet Selcuk Gedik ◽  
Kemal Korkmaz ◽  
Baran Budak ◽  
Umit Yener ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Mitral Valve Repair ◽  
Mitral Valve Surgery ◽  
Left Ventricular ◽  
Ischemic Mitral Regurgitation ◽  
Post Myocardial Infarction ◽  
Valve Repair ◽  
Left Ventricular Restoration

Transventricular mitral valve surgery combined with left ventricular restoration avoids atriotomy and provides a larger operative field. We describe a series of 5 patients in whom we performed transventricular mitral valve repair by various techniques, such as band annuloplasty, papillary muscle reattachment, chordal cutting, and edge-to-edge repair. The more acute forms of ischemic mitral regurgitation, as found in our patients, can coexist with post-myocardial infarction contained rupture or post-myocardial infarction ventricular septal rupture. Because these patients already have an indication for ventriculotomy, concomitant transventricular repair of the mitral valve can render a separate atriotomy unnecessary and thereby shorten the duration of cardiopulmonary bypass. Moreover, in patients with acute presentations, the absence of atrial dilation (this last associated with chronic cases) might make transventricular repair a better choice than the more difficult atrial approach.

scholarly journals Impact of Papillary Muscle Infarction on Ischemic Mitral Regurgitation Assessed by Magnetic Resonance Imaging

2017 ◽  
Vol 190 (01) ◽  
pp. 42-50 ◽  
Author(s):  
Christiane Bretschneider ◽  
Hannah-Klara Heinrich ◽  
Achim Seeger ◽  
Christof Burgstahler ◽  
Stephan Miller ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Mitral Regurgitation ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Papillary Muscle ◽  
Left Ventricular ◽  
Ischemic Mitral Regurgitation ◽  
Chronic Myocardial Infarction ◽  
End Diastolic Volume ◽  
Significant Difference

Objective Ischemic mitral regurgitation is a predictor of heart failure resulting in increased mortality in patients with chronic myocardial infarction. It is uncertain whether the presence of papillary muscle (PM) infarction contributes to the development of mitral regurgitation in patients with chronic myocardial infarction (MI). The aim of the present study was to assess the correlation of PM infarction depicted by MRI with mitral regurgitation and left ventricular function. Methods and Materials 48 patients with chronic MI and recent MRI and echocardiography were retrospectively included. The location and extent of MI depicted by MRI were correlated with left ventricular function assessed by MRI and mitral regurgitation assessed by echocardiography. The presence, location and extent of PM infarction depicted by late gadolinium enhancement (LGE-) MRI were correlated with functional parameters and compared with patients with chronic MI but no PM involvement. Results PM infarction was found in 11 of 48 patients (23 %) using LGE-MRI. 8/11 patients (73 %) with PM infarction and 22/37 patients (59 %) without PM involvement in MI had ischemic mitral regurgitation. There was no significant difference between location, extent of MI and presence of mitral regurgitation between patients with and without PM involvement in myocardial infarction. In 4/4 patients with complete and in 4/7 patients with partial PM infarction, mitral regurgitation was present. The normalized mean left ventricular end-diastolic volume was increased in patients with ischemic mitral regurgitation. Conclusion The presence of PM infarction does not correlate with ischemic mitral regurgitation. In patients with complete PM infarction and consequent discontinuity of viable tissue in the PM-chorda-mitral valve complex, the probability of developing ischemic mitral regurgitation seems to be increased. However, the severity of mitral regurgitation is not increased compared to patients with partial or no PM infarction. Key points  Citation Format

Ischemic Mitral Regurgitation and Non-ST-Segment Elevation Acute Myocardial Infarction: Long-Term Prognosis

2009 ◽  
Vol 62 (11) ◽  
pp. 1267-1275 ◽  
Author(s):  
Iván Javier Núñez Gil ◽  
Leopoldo Pérez de Isla ◽  
Juan Carlos García-Rubira ◽  
Antonio Fernández-Ortiz ◽  
Juan José González Ferrer ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Mitral Regurgitation ◽  
Ischemic Mitral Regurgitation ◽  
St Segment Elevation ◽  
St Segment ◽  
Long Term Prognosis ◽  
Elevation Acute Myocardial Infarction

scholarly journals A Coronary Conundrum: Papillary Muscle Rupture and Ischemic Mitral Regurgitation Secondary to Coronary Thromboembolism in Antiphospholipid Syndrome

2019 ◽  
Vol 7 ◽  
pp. 232470961984224
Author(s):  
Amar Shere ◽  
Pradyumna Agasthi ◽  
Farouk Mookadam ◽  
Sudheer Konduru ◽  
Reza Arsanjani
Keyword(s):  
Myocardial Infarction ◽  
Mitral Regurgitation ◽  
Antiphospholipid Syndrome ◽  
Papillary Muscle ◽  
Rare Complication ◽  
Autoimmune Disorder ◽  
Ischemic Mitral Regurgitation ◽  
Papillary Muscle Rupture ◽  
Muscle Rupture ◽  
Uncommon Case

Antiphospholipid syndrome (APS) is an autoimmune disorder that has a strong propensity for a hypercoagulable state and is known to be associated with venous and arterial thromboembolism. We describe an uncommon case of APS in the setting of non-Hodgkin’s lymphoma, with thromboembolism, and a rare complication after an uncommon etiology of myocardial infarction. This case highlights the importance of early and appropriate type of anticoagulation to reduce the morbidity and mortality in patients with APS.

Impact of Infarct Location on Development of Ischemic Mitral Regurgitation in Patients with Acute Myocardial Infarction

2014 ◽  
Vol 20 (10) ◽  
pp. S200
Author(s):  
Kitae Kim ◽  
Shuichiro Kaji ◽  
Takeshi Kitai ◽  
Tomoko Tani ◽  
Makoto Kinoshita ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Mitral Regurgitation ◽  
Ischemic Mitral Regurgitation

scholarly journals Mitral Regurgitation Augments Post-Myocardial Infarction Remodeling

2008 ◽  
Vol 51 (4) ◽  
pp. 476-486 ◽  
Author(s):  
Ronen Beeri ◽  
Chaim Yosefy ◽  
J. Luis Guerrero ◽  
Francesca Nesta ◽  
Suzan Abedat ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Mitral Regurgitation ◽  
Post Myocardial Infarction
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