scholarly journals High sympathetic tone in development of the left ventricle hypertrophy and beta-blockers for regression

2018 ◽  
pp. 77-88
Author(s):  
О. D. Ostroumova ◽  
A. I. Kochetkov ◽  
M. V. Lopukhina ◽  
E. Е. Pavleeva
Keyword(s):  
Left Ventricle ◽  
Beta Blockers ◽  
Target Organ ◽  
Current Evidence ◽  
Systemic Hypertension ◽  
Prognostic Role ◽  
Heart Lesion ◽  
Left Ventricle Hypertrophy ◽  
Ventricle Hypertrophy

The review is focused on clinical significance of the left ventricle hypertrophy (LVH) — presentation of heart lesion as a target organ for systemic hypertension (SH). Various LVH development mechanisms are presented, and special attention is paid to sympathic nervous system and β-adrenoreceptors in pathogenesis. Fundamental methods of diagnostics are described for LVH, in comparison. The pathology is classified from the perspective of recent guidelines on echocardiographic diagnostics. Epidemiology provided. Taken current evidence, the prognostic role of LVH is described as a factor increasing the risk of fatal and non-fatal cardiovascular, cerebrovascular and renal complications in SH patients. Trials data presented that points on LVH regression with highly selective β1-blocker bisoprolol treatment. Pathophysiology of LVH regression is discussed for β1-blocker treatment.

Role of Arterial Hypertension in Left Ventricle Hypertrophy in Hemodialysis Patients: An Echocardiographic Study

Cardiology ◽  
1992 ◽  
Vol 80 (3-4) ◽  
pp. 161-167 ◽  
Author(s):  
José J.G De Lima ◽  
Henry Abensur ◽  
Helio Bernardes-Silva ◽  
Giovanni Bellotti ◽  
Fulvio Pileggi
Keyword(s):  
Left Ventricle ◽  
Arterial Hypertension ◽  
Hemodialysis Patients ◽  
Left Ventricle Hypertrophy ◽  
Echocardiographic Study ◽  
Ventricle Hypertrophy

Abstract W P250: The Impact of Acute Hypertensive Response on Mortality After Intracerebral Hemorrhage Differs Among Patients With and Without Left Ventricle Hypertrophy

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Octavio M Pontes-Neto ◽  
Sergi Martinez-Ramirez ◽  
Anand Viswanathan ◽  
Timothy C Tan ◽  
Maria C Nunes ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Left Ventricle ◽  
Acute Phase ◽  
Blood Pressure Reduction ◽  
Chronic Hypertension ◽  
Pressure Reduction ◽  
Left Ventricle Hypertrophy ◽  
Ventricle Hypertrophy ◽  
Haenszel Test ◽  
Intensive Blood Pressure

Background: While acute hypertensive response (AHR) predicts worse outcome in intracerebral hemorrhage (ICH), the INTERACT-2 trial recently failed to definitively demonstrate a major benefit of intensive blood pressure reduction on these patients. A possible explanation is that the detrimental effect of AHR on outcome may differ among ICH patients with and without previous chronic hypertension. Objective: to explore whether the prognosis of patients with AHR during the acute phase of ICH differs according to the presence or absence of left ventricle hypertrophy (LVH), which is a marker of chronic hypertensive organ damage. Method: we performed a retrospective analysis of a prospective cohort of patients with primary ICH presenting to an academic hospital between January/2000 and December/2012 with age > 18 years, who had a transthoracic echocardiogram available. LVH was defined according to Penn convention. AHR was defined as systolic blood pressure > 180 mmHg on admission. Mantel-Haenszel test was initially used to assess if LVH status influenced the effect of AHR on mortality. For subsequent analyses, ICH patients were divided in 3 groups: without AHR (reference); AHR without LVH; AHR with LVH. A multivariate logistic regression model was then used to identify independent predictors of mortality at 30-days. Results: 430 patients met inclusion criteria. AHR was present in 196 (46.6%), LVH was present in 233 (54.2%); 30-day mortality was 15.6%. On Mantel-Haenszel test, we found a trend (p=0.09) suggesting that absence of LVH increased AHR effect on mortality (OR:1.64; 95% CI: 0.95-2.8; p=0.07). On multivariate analysis, patients with AHR without LVH had significantly higher mortality (OR: 2.65; 95%CI: 1.15 to 6.1; p=0.022) when compared to patients without AHR, after adjusting for baseline characteristics. There was only a trend towards increased mortality in the group of patients with AHR and LVH (OR:2.22; 95% CI: 0.99-5.0; p=0.053). Conclusions: Patients without chronic hypertension appear to be more susceptible to the detrimental effects of AHR during the acute phase of ICH. Stratification of patients with ICH may help to identify those that will have greater benefit with intensive blood pressure reduction in the acute phase of ICH.

scholarly journals ECG-based detection of left ventricle hypertrophy

2015 ◽  
Vol 31 (2) ◽  
pp. 125-132 ◽  
Author(s):  
Gabriel Tozatto Zago ◽  
Rodrigo Varejão Andreão ◽  
Sérgio Lamego Rodrigues ◽  
José Geraldo Mill ◽  
Mário Sarcinelli Filho
Keyword(s):  
Left Ventricle ◽  
Left Ventricle Hypertrophy ◽  
Ventricle Hypertrophy

scholarly journals Longitudinal Mitral Annulus Velocities Are Reduced in Hypertensive Subjects With or Without Left Ventricle Hypertrophy

Hypertension ◽  
2006 ◽  
Vol 47 (5) ◽  
pp. 854-860 ◽  
Author(s):  
Maria Cândida C. Borges ◽  
Roberta C.R. Colombo ◽  
José Geraldo F. Gonçalves ◽  
José de Oliveira Ferreira ◽  
Kleber G. Franchini
Keyword(s):  
Left Ventricle ◽  
Mitral Annulus ◽  
Left Ventricle Hypertrophy ◽  
Ventricle Hypertrophy

scholarly journals Analysis of NT-proBNP and uric acid due to left ventricle hypertrophy in the patients of aortic valve disease

2018 ◽  
Vol 35 (1) ◽  
Author(s):  
Muhammad Ishtiaq Jan ◽  
Riaz Anwar Khan ◽  
Aneesa Sultan ◽  
Anwar Ullah ◽  
Ayesha Ishtiaq ◽  
...  
Keyword(s):  
Uric Acid ◽  
Aortic Valve ◽  
Left Ventricle ◽  
Aortic Stenosis ◽  
Serum Uric Acid ◽  
Aortic Valve Disease ◽  
Severe Stenosis ◽  
Valve Dysfunction ◽  
Left Ventricle Hypertrophy ◽  
Ventricle Hypertrophy

Objective: To evaluate the concentration of N terminal proBNP (NT-proBNP) and partially the serum uric acid in the severe condition of aortic valve dysfunction for assessment of left ventricle hypertrophy. Methods: The study was conducted in the signal transduction lab department of biochemistry Quaid-I-Azam University, Islamabad from September 2013 to February 2017. NT-proBNP and serum uric acid were measured in one hundred patients of aortic valve dysfunction. The patients were divided into three main groups: 1) Aortic stenosis, 2) Aortic regurgitation, and 3) Aortic stenosis with Aortic regurgitation. The results were compared between disease and controls groups. Results: High level of plasma NT-proBNP was detected in all the three disease groups of aortic valve (stenosis, p<0.001), (regurgitation, p<0.001) and (stenosis with regurgitation, p<0.001). In addition, non-significantly increased level of serum uric acid was also observed in left ventricle hypertrophy in all the three respective disease groups of aortic valve. Conclusion: Increased secretion of NT-proBNP during cardiac remodeling can be related to the severity of left ventricle hypertrophy due to aortic valve abnormality in all the disease groups of severe stenosis, severe regurgitation, and combine disease condition of severe stenosis and severe regurgitation. However, non-significant increase in uric acid concentration is also identified which may be due to one of the factors involved in left ventricle hypertrophy in all the three disease groups of aortic valve. The interaction of uric acid with NT-proBNP during cardiac remolding due to aortic valve dysfunction is still not clear. How to cite this:Jan MI, Khan RA, Sultan A, Ullah A, Ishtiaq A, Murtaza I. Analysis of NT-proBNP and uric acid due to left ventricle hypertrophy in the patients of aortic valve disease. Pak J Med Sci. 2019;35(1):---------. doi: https://doi.org/10.12669/pjms.35.1.148 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals P2856Predictors of survival in hypertensive patients with left ventricle hypertrophy

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
B Guzik ◽  
L McCallum ◽  
K Zmudka ◽  
A Jardine ◽  
T J Guzik ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Hypertensive Patients ◽  
Left Ventricle Hypertrophy ◽  
Ventricle Hypertrophy
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