ARTERIAL WALL REMODELING AND A RISK OF LEFT VENTRICLE HYPERTROPHY IN HIGH COMPLIANCE PATIENTS WITH ARTERIAL HYPERTENSION

Aim. To study the distribution of cardiovascular risk factors, target organ damage, associated clinical conditions and to stratify the 10-year risk of arterial hypertension complications in menopausal females depending on presence of inappropriately high left ventricular mass. Methods. 107 females from city of Kazan aged 42-59 years entered the study, including 11 women with normal blood pressure, 16 patients with high normal blood pressure, and 80 patients with hypertension according to All-Russia scientific Society of Cardiologists classification (2010) with disease duration of 0-34 years. Mean age of patients with hypertension was 51.4±4.0 years. Patients with secondary hypertension were excluded from the study. All patients underwent a questionnaire survey, physical examination, biochemical blood test, ECG, echocardiography, and cervical extracranial vessel ultrasonography. Actual left ventricle mass was calculated according to R.B. Devereux et al. (1977) and was adjusted to the body surface area. Proper left ventricle mass was defined by G. Simone et al. (1998). Disproportion coefficient was calculated as a ratio of actual left ventricle mass to proper left ventricle mass. Left ventricle hypertrophy was diagnosed using the Sokolow-Lyon index and left ventricle mass index ≥ 110 g/m2 (Echo-signs of left ventricle hypertrophy). Results. In menopausal women, inappropriately high left ventricular mass was associated with significantly (р 0.05, Fisher exact test) higher frequency of obesity, especially its abdominal type, as well as target organ damage, including Echo-signs of left ventricle hypertrophy, very high added 10-year risk of developing arterial hypertension complications. It was also associated with significantly (р 0.05, the U-criterion) higher mean values of waist circumference, waist to hip circumference ratio, body mass index, total number of damaged target organs and 10-year risk for developing arterial hypertension complications. Conclusion. Distinguishing the patients with inappropriately high left ventricular mass among menopausal women is important for planning the measures to prevent cardiovascular events.

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The vegetative regulation and central hemodynamics at ischemic heart disease patients with arterial hypertension and various types of the left ventricle hypertrophy

Arterial’naya Gipertenziya (Arterial Hypertension) ◽

10.18705/1607-419x-2003-9-3-92-94 ◽

2003 ◽

Vol 9 (3) ◽

pp. 92-94

Author(s):

A. L. Syrkin ◽

A. M. Vejn ◽

A. D. Ibatov ◽

E. A. Syrkina ◽

R. M. Baevsky ◽

...

Keyword(s):

Nervous System ◽

Heart Disease ◽

Left Ventricle ◽

Ischemic Heart Disease ◽

Arterial Hypertension ◽

Ischemic Heart ◽

Orthostatic Test ◽

Left Ventricle Hypertrophy ◽

Vegetative Regulation ◽

Ventricle Hypertrophy

We examined 76 ischemic heart disease patients with arterial hypertension and a left ventricle hypertrophy. All patients had cardiovascular tests, heart rate variability examination, integral rheography examination in rest and at orthostatic test. Patients divided into two groups on character of left ventricle hypertrophy. The ischemic heart disease patients with concentric left ventricle hypertrophy differed from patients with eccentric left ventricle hypertrophy (LVH) more long current of ischemic heart disease and hypertension, had in rest higher activation of sympathetic link autonomic nervous system and higher level of peripheral vascular resistance. However activation of sympathetic nervous system was more expressed at patients with eccentric LVH at orthostatic test and this activation was kept in rest after orthostatic test, that shows lower compensation of these patients.

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