CARDIOVASCULAR PATHOLOGY IN ACUTE STROKE (ISSUES ON PREVALENCE, PREVENTION AND TREATMENT)

The article concerns on the problems of vascular comorbidity epidemiology and pathophysiological aspects of heart disease, which became a leading etiopathologic factor of cerebral infarctions and hemorrhages. The relationship between coronary artery disease (CAD), atrial fibrillation, hypertension and cerebral infarction types is emphasized.Aim.To analyze the role of comorbidity, attributable to cardio-vascular pathology in the initiation, course, clinical features and outcomes of cerebral infarction.Material and methods.We performed a prospective study, including 1072 patients with stroke, attributable to various cardiovascular pathology, evaluated the influence of vascular comorbidity of variable degree on the course and outcomes at an inpatient stage and at follow-up.Results.We demonstrated a negative influence of CAD, atrial fibrillation and postinfarction cardiosclerosis on the incidence of cerebral infarction, unfavorable course of the disease and functional outcomes at inpatient stage. The combination of vascular comorbidity resulted in an increased mortality in post-stroke period during 6 years of follow-up.Conclusion.Epidemiology of vascular comorbidity, its role in cerebrovascular accidents in patients with cardiac pathology justifies the need of active realization of contemporary multidisciplinary prevention programs, prolonged instrumental monitoring and implementation of energy deficiency correction therapy in comprehensive treatment programs.

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Modern treatment strategies in patients with vascular comorbidity Part 1. Correcting tissue energy deficiency

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2012-6-44-49 ◽

2012 ◽

Vol 11 (6) ◽

pp. 44-49 ◽

Cited By ~ 5

Author(s):

S. A. Rumyantseva ◽

R. G. Oganov ◽

E. V. Silina ◽

V. A. Stupin ◽

S. B. Bolevich ◽

...

Keyword(s):

Therapeutic Potential ◽

Treatment Strategies ◽

Vascular Pathology ◽

Cerebral Stroke ◽

Post Discharge ◽

Energy Deficiency ◽

Therapeutic Algorithms ◽

Stroke Disability ◽

Active Implementation ◽

Vascular Comorbidity

The first paper of the series on the treatment of patients with vascular comorbidity (VC) is focused on the role and therapeutic potential of the correction of free radical processes (FRP) as pathogenetic factors of multifocal vascular pathology. Aim. To analyse the effects of VC on the incidence and outcomes of cerebral stroke (S), in order to create therapeutic algorithms of FRP correction. Material and methods. This prospective study included 634 S patients. The following factors were analysed: pre-stroke disability due to various VC variants; VC effects on the clinical course, as well as in-hospital and post-discharge outcomes; and FRP specifics in various VC variants. Results. VC was registered in 97% of S patients; in 45,3%, it resulted in pre-stroke disability. FRP parameters, reflecting the progression of tissue energy deficiency, differed significantly in patients with coronary heart disease, myocardial infarction, atrial fibrillation, and diabetes mellitus. Based on these findings, the therapeutic algorithms for effective energy deficiency correction have been created. Conclusion. The analysis of pre- and post-stroke disability and prevention of repeat events in cardiovascular patients has demonstrated the need for a more active implementation of modern multidisciplinary preventive programs.

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