scholarly journals Psychological aspects of cardiovascular diseases

2021 ◽  
Vol 16 (11-12) ◽  
pp. 369-369
Author(s):  
Ana Marinić ◽  
Vjera Pisačić ◽  
Valentina Jezl ◽  
Danijela Gregurević
Keyword(s):  
Cardiovascular Diseases ◽  
Psychological Aspects

scholarly journals Medico-Social and Psychological Aspects of Cardiovascular Diseases

2016 ◽  
Vol 8 (6) ◽  
Author(s):  
Saida Alirzaevna Magomedova ◽  
Angela Sergeevna Damadaeva
Keyword(s):  
Cardiovascular Diseases ◽  
Psychological Aspects

Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies

2020 ◽  
Vol 134 (17) ◽  
pp. 2243-2262
Author(s):  
Danlin Liu ◽  
Gavin Richardson ◽  
Fehmi M. Benli ◽  
Catherine Park ◽  
João V. de Souza ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Nlrp3 Inflammasome ◽  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Therapeutic Interventions ◽  
Low Grade ◽  
Cardiovascular Research ◽  
Inflammatory Processes ◽  
Ach Receptors

Abstract In the elderly population, pathological inflammation has been associated with ageing-associated diseases. The term ‘inflammageing’, which was used for the first time by Franceschi and co-workers in 2000, is associated with the chronic, low-grade, subclinical inflammatory processes coupled to biological ageing. The source of these inflammatory processes is debated. The senescence-associated secretory phenotype (SASP) has been proposed as the main origin of inflammageing. The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD+ metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging molecular targets. It has been shown that inflammageing is a hallmark of various cardiovascular diseases, including atherosclerosis, hypertension, and adverse cardiac remodelling. Therefore, the pathomechanism involving SASP activation via the NLRP3 inflammasome; modulation of NLRP3 via α7 nicotinic ACh receptors; and modulation by senolytics targeting other proteins have gained a lot of interest within cardiovascular research and drug development communities. In this review, which offers a unique view from both clinical and preclinical target-based drug discovery perspectives, we have focused on cardiovascular inflammageing and its molecular mechanisms. We have outlined the mechanistic links between inflammageing, SASP, interleukin (IL)-1β, NLRP3 inflammasome, nicotinic ACh receptors, and molecular targets of senolytic drugs in the context of cardiovascular diseases. We have addressed the ‘druggability’ of NLRP3 and nicotinic α7 receptors by small molecules, as these proteins represent novel and exciting targets for therapeutic interventions targeting inflammageing in the cardiovascular system and beyond.

Psychological Aspects of Malignant Disease in Childhood

1981 ◽  
Vol 26 (2) ◽  
pp. 133-134
Author(s):  
E. James Anthony
Keyword(s):  
Malignant Disease ◽  
Psychological Aspects

Psychological aspects of occupational health.

1999 ◽  
Author(s):  
Michael J. Smith ◽  
Marla C. Haims ◽  
Francisco B. P. Moro ◽  
Ben-Tzion Karsh ◽  
Larry J. Chapman ◽  
...  
Keyword(s):  
Occupational Health ◽  
Psychological Aspects
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