Unraveling the mechanisms underlying postural instability in Parkinson’s disease using dynamic posturography

Abstract Background Parkinson’s disease (PD) is a degenerative, progressive, neurological condition that influences the control of a person’s body movements. Computerized dynamic posturography (CDP) is a clinical tool intended to evaluate the integration of visual, vestibular, and somatosensory inputs to maintain postural gait. Posturography can be used to measure postural instability in PD patients. So, the aim of this study was to evaluate the postural control and elaborate on the pathophysiology of the balance impairment in PD patients in the “on” state. Results All antero-posterior (AP) and medio-lateral (ML) sensory balance scores, except vestibular ones, were significantly lower in the study group compared to the control group. AP and ML sway were generally higher in the study group at all frequencies, with AP being mostly greater compared to ML sway in PD subjects. Global sensory scores were shown to deteriorate with increased durations of the disease and treatment. Conclusions PD patients have higher postural instability in comparison to controls with AP sway being higher compared to ML.

Download Full-text

Postural Instability and Cognitive Dysfunction in Early Parkinson's Disease

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100013986 ◽

2012 ◽

Vol 39 (4) ◽

pp. 473-482 ◽

Cited By ~ 22

Author(s):

Jong Moon Lee ◽

Seong-Beom Koh ◽

Sung Won Chae ◽

Woo-Keun Seo ◽

Do Young Kwon ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Early Stage ◽

Postural Instability ◽

Sensory Organization Test ◽

Yahr Stage ◽

Dynamic Posturography ◽

Motor Latency ◽

Sensory Organization ◽

Computerized Dynamic Posturography

Background:Postural instability is one of the most disabling features of Parkinson's disease, usually occurring in late and advanced stages. The aim of this study was to investigate the postural performance of early-stage de novo Parkinson's disease patients with no clinical postural instability using computerized dynamic posturography. We sought to understand the relationship between postural sway and disease severity and the relationship between postural instability quantitatively measured by computerized dynamic posturography and cognitive impairment in early-stage Parkinson's disease patients.Method:Thirty-one subjects with Parkinson's disease and 20 healthy controls were assessed by the computerized dynamic posturography protocol using the sensory organization test and the motor control test. A neuropsychological assessment was also administered.Results:The mean equilibrium score for sensory organization test and the vestibular input ratio were significantly correlated with Hoehn-Yahr stage. No associations between motor latency for any motor control test condition and Hoehn-Yahr stage were found. The equilibrium score for sensory organization test correlated with the mini-mental status examination scores. There was a significant correlation between motor latency for large backward translation and mini-mental status examination scores. There were significant correlations between visual perception/construction/ memory of the neuropsychological battery test and the equilibrium score for sensory organization test and between verbal word learning test, controlled word association test and motor latency for large backward translation.Conclusion:These findings showed the postural instability present in early-stage (Hoehn-Yahr stage 2-2.5) Parkinson's disease. We also found a close relationship between postural instability and cognitive function in Parkinson's disease patients.

Download Full-text

Rapid assessment of postural instability in Parkinson’s disease (RAPID): a pilot study

European Journal of Neurology ◽

10.1111/j.1468-1331.2010.03115.x ◽

2011 ◽

Vol 18 (2) ◽

pp. 260-265 ◽

Cited By ~ 16

Author(s):

R. K. Y. Chong ◽

J. Morgan ◽

S. H. Mehta ◽

I. Pawlikowska ◽

P. Hall ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Pilot Study ◽

Rapid Assessment ◽

Postural Instability

Download Full-text

Postural instability in Parkinson?s disease ? 120 years after Charcot?s death

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20140085 ◽

2014 ◽

Vol 72 (8) ◽

pp. 633-635 ◽

Cited By ~ 1

Author(s):

Hélio Afonso Ghizoni Teive ◽

Renato Puppi Munhoz

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Postural Instability

The authors present the original Charcot’s description of postural instability in Parkinson’s disease as well as the evolution of this sign after 120 years of Charcot’s death.

Download Full-text