Use of lung cancer risk models in planning research and service programs in CT screening for lung cancer

2009 ◽  
Vol 9 (10) ◽  
pp. 1467-1472 ◽  
Author(s):  
Stephen W Duffy ◽  
Olaide Y Raji ◽  
Olorunsola F Agbaje ◽  
Prue C Allgood ◽  
Adrian Cassidy ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Risk Models ◽  
Ct Screening ◽  
Service Programs

The effect of radiographic emphysema in assessing lung cancer risk

Thorax ◽  
2019 ◽  
Vol 74 (9) ◽  
pp. 858-864 ◽  
Author(s):  
Patrick C Yong ◽  
Keith Sigel ◽  
Juan Pablo de-Torres ◽  
Grace Mhango ◽  
Minal Kale ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Cancer Diagnosis ◽  
Lung Cancer Risk ◽  
Risk Scores ◽  
Risk Models ◽  
Lung Cancer Diagnosis ◽  
National Lung Screening Trial ◽  
Lung Screening

PurposeLung cancer risk models optimise screening by identifying subjects at highest risk, but none of them consider emphysema, a risk factor identifiable on baseline screen. Subjects with a negative baseline low-dose CT (LDCT) screen are at lower risk for subsequent diagnosis and may benefit from risk stratification prior to additional screening, thus we investigated the role of radiographic emphysema as an additional predictor of lung cancer diagnosis in participants with negative baseline LDCT screens of the National Lung Screening Trial.MethodsOur cohorts consist of participants with a negative baseline (T0) LDCT screen (n=16 624) and participants who subsequently had a negative 1-year follow-up (T1) screen (n=14 530). Lung cancer risk scores were calculated using the Bach, PLCOm2012 and Liverpool Lung Project models. Risk of incident lung cancer diagnosis at the end of the study and number screened per incident lung cancer were compared between participants with and without radiographic emphysema.ResultsRadiographic emphysema was independently associated with nearly double the hazard of lung cancer diagnosis at both the second (T1) and third (T2) annual LDCT in all three risk models (HR range 1.9–2.0, p<0.001 for all comparisons). The number screened per incident lung cancer was considerably lower in participants with radiographic emphysema (62 vs 28 at T1 and 91 vs 40 at T2).ConclusionRadiographic emphysema is an independent predictor of lung cancer diagnosis and may help guide decisions surrounding further screening for eligible patients.

Abstract A127: Comparison of discriminatory power and accuracy of three lung cancer risk models

2010 ◽  
Author(s):  
Anthony M. D'Amelio ◽  
Adrian Cassidy ◽  
Kofi Asomaning ◽  
Olaide Y. Raji ◽  
Stephen W. Duffy ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Discriminatory Power ◽  
Risk Models

scholarly journals Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom

2021 ◽  
Author(s):  
Hilary A. Robbins ◽  
Karine Alcala ◽  
Anthony J. Swerdlow ◽  
Minouk J. Schoemaker ◽  
Nick Wareham ◽  
...  
Keyword(s):  
Lung Cancer ◽  
United Kingdom ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Risk Models ◽  
Comparative Performance ◽  
The United Kingdom ◽  
Lung Screening

CT screening for lung cancer: Risk of dying of “competing” causes of death

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 7185-7185 ◽  
Author(s):  
R. Yip ◽  
C. I. Henschke ◽  
D. Yankelevitz
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Causes Of Death ◽  
Lung Cancer Risk ◽  
Ct Screening ◽  
Competing Causes

scholarly journals Comparison of discriminatory power and accuracy of three lung cancer risk models

2010 ◽  
Vol 103 (3) ◽  
pp. 423-429 ◽  
Author(s):  
A M D'Amelio ◽  
A Cassidy ◽  
K Asomaning ◽  
O Y Raji ◽  
S W Duffy ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Discriminatory Power ◽  
Risk Models

scholarly journals Correction: Comparative performance of lung cancer risk models to define lung screening eligibility in the United Kingdom

2021 ◽  
Author(s):  
Hilary A. Robbins ◽  
Karine Alcala ◽  
Anthony J. Swerdlow ◽  
Minouk J. Schoemaker ◽  
Nick Wareham ◽  
...  
Keyword(s):  
Lung Cancer ◽  
United Kingdom ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Risk Models ◽  
Comparative Performance ◽  
The United Kingdom ◽  
Lung Screening
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