The effects of self-mobilization techniques for the sciatic nerves on physical functions and health of low back pain patients with lower limb radiating pain

Background and Objectives: Musculoskeletal dysfunction can induce several types of chronic pain syndromes. It is of particular interest to elucidate the pathomechanism of different forms of chronic pain. It is possible that patients who have developed chronic widespread pain (CWP) may endure different pathomechanisms as compared to those who suffer from local pain (osteoarthritis, OA) and regional pain (chronic low back pain, cLBP), especially with regard to pain regulation and its related biomediators. The aim of this study was to determine the differences in pathomechanisms among these patients by measuring pain-related biomediators, particularly brain-derived neurotrophic factor (BDNF). Additionally, subpopulations of immune cells were determined in parallel. Materials and Methods: Patients and healthy subjects (HSs) were recruited (age and gender-matched). BDNF was measured from serum samples of patients and HSs and the data of body composition parameters were recorded. Additionally, both patients and HSs were asked to fill in questionnaires related to pain intensity, anxiety, and depression. Results: Our results highlight that the levels of both free and total BDNF are significantly lower in pain patients compared to HSs, with p values of 0.041 and 0.024, respectively. The number of CD3− CD56bright natural killer (NK) cells shows significant differences between the groups. Comparing all chronic pain patients with HSs reveals a significantly lower number of CD4+ CD8+ T cells (p = 0.031), CD3− CD56bright NK cells (p = 0.049) and CD20+ CD3− cells (p = 0.007). Conclusions: To conclude, it seems that a general conformity between the pathomechanisms of different chronic pain diseases exists, although there are unique findings only in specific chronic pain patients.

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Predictive factors of high societal costs among chronic low back pain patients

European Journal of Pain ◽

10.1002/ejp.1488 ◽

2019 ◽

Vol 24 (2) ◽

pp. 325-337 ◽

Cited By ~ 2

Author(s):

Elizabeth N. Mutubuki ◽

Mariette A. Luitjens ◽

Esther T. Maas ◽

Frank J. P. M. Huygen ◽

Raymond W. J. G. Ostelo ◽

...

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Predictive Factors ◽

Chronic Low Back Pain ◽

Low Back ◽

Societal Costs ◽

Pain Patients

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Activity Characteristics and Movement Patterns in People With and People Without Low Back Pain Who Participate in Rotation-Related Sports

Journal of Sport Rehabilitation ◽

10.1123/jsr.22.3.161 ◽

2013 ◽

Vol 22 (3) ◽

pp. 161-169 ◽

Cited By ~ 8

Author(s):

Ruth L. Chimenti ◽

Sara A. Scholtes ◽

Linda R. Van Dillen

Keyword(s):

Risk Factor ◽

Low Back Pain ◽

Back Pain ◽

Lower Limb ◽

Movement Pattern ◽

Low Back ◽

Habitual Activity ◽

Design Case ◽

Lower Limb Movement ◽

Activity Questionnaire

Many risk factors have been identified as contributing to the development or persistence of low back pain (LBP). However, the juxtaposition of both high and low levels of physical activity being associated with LBP reflects the complexity of the relationship between a risk factor and LBP. Moreover, not everyone with an identified risk factor, such as a movement pattern of increased lumbopelvic rotation, has LBP.Objective:The purpose of this study was to examine differences in activity level and movement patterns between people with and people without chronic or recurrent LBP who participate in rotation-related sports.Design Case:Case-control study.Setting:University laboratory environment.Participants:52 people with chronic or recurrent LBP and 25 people without LBP who all play a rotation-related sport.Main Outcome Measures:Participants completed self-report measures including the Baecke Habitual Activity Questionnaire and a questionnaire on rotation-related sports. A 3-dimensional motion-capture system was used to collect movement-pattern variables during 2 lower-limb-movement tests.Results:Compared with people without LBP, people with LBP reported a greater difference between the sport subscore and an average work and leisure composite subscore on the Baecke Habitual Activity Questionnaire (F = 6.55, P = .01). There were no differences between groups in either rotation-related-sport participation or movement-pattern variables demonstrated during 2 lower-limb-movement tests (P > .05 for all comparisons).Conclusions:People with and people without LBP who regularly play a rotation-related sport differed in the amount and nature of activity participation but not in movement-pattern variables. An imbalance between level of activity during sport and daily functions may contribute to the development or persistence of LBP in people who play a rotation-related sport.

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