Vitamin D deficiency and its relationship with bone mineral density among postmenopausal women living in the tropics

OBJECTIVE: To determine vitamin D (25OHD) status and its relationship with bone mineral density (BMD) in 93 postmenopausal women. SUBJECTS AND METHODS: Patients were distributed in two groups: Group 1 - 51 to 65 years (n = 45) and Group 2 - 66 to 84 years (n = 48); 25OHD and PTH serum were analyzed and a DXA scan of the lumbar spine (LS) and femoral neck (FN) were taken. RESULTS: Mean ± SD of serum 25OHD levels were 80.6 ± 43.3 nmol/L (Group 1) and 63.7 ± 27.6 nmol/L (Group 2); 24% had 25OHD levels < 25 nmol/L and 43.7% < 50 nmol/L. The prevalence of vitamin D deficiency at the 62.5 nmol/L cutoff increased significantly with age. Patients with hypovitaminosis D had a lower BMD at the FN (0.738 ± 0.102 vs. 0.793 ± 0.115 g/cm, p = 0.03) and had been postmenopausal for longer (21.0 ± 8.4 vs. 16.2 ± 8.4 years, p = 0.01). CONCLUSION: We found a high prevalence of hypovitaminosis D in postmenopausal women. Age, years elapsed since menopause and low BMD in the FN were associated with deficiency.

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AB0651 Influence of corticosteroid therapy and vitamin D deficiency on bone mineral density in postmenopausal women with systemic lupus erythematosus

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2012-eular.651 ◽

2013 ◽

Vol 71 (Suppl 3) ◽

pp. 676.1-676

Author(s):

D. Marcetic ◽

R. Stojanovic ◽

R. Petrovic

Keyword(s):

Bone Mineral Density ◽

Systemic Lupus Erythematosus ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Postmenopausal Women ◽

Corticosteroid Therapy ◽

Bone Mineral ◽

Lupus Erythematosus ◽

Mineral Density ◽

Systemic Lupus

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Factors influencing bone mineral density in postpartum women

Osteoporosis and Bone Diseases ◽

10.14341/osteo9653 ◽

2018 ◽

Vol 21 (1) ◽

pp. 10-16

Author(s):

Tatiana V. Novikova ◽

Lubov V. Kuznetsova ◽

Natalia Yu. Yakovleva ◽

Irina E. Zazerskaya

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Lumbar Spine ◽

Vitamin D Deficiency ◽

Distal Radius ◽

Bone Mineral ◽

Calcium Intake ◽

Z Score ◽

Mineral Density ◽

Group 1

Background: Osteopenia is a common condition. Therefore, identification of groups for prevention of osteoporosis and restoration of bone mineral density (BMD) remains relevant. Aim: to assess the factors contributing to development of osteopenia in puerperas. Methods: prospective cross-sectional study. We examined 112 patients aged 20-35, 3-5 days after delivery. To assess possible factors for BMD decrease, we analyzed medical history, lifestyle, nutrition, anthropometric data, obstetric and gynecological history, and pregnancy course. We also assessed serum levels of 25-hydroxycalciferol (25-OH-D) and PTH. BMD was measured by dual energy x-ray osteodensitometry. We considered Z-score from -1 to -2.5SD as osteopenia, below -2.5 SD-as osteoporosis. Results: based on Z-score values, two groups were formed: 1 (n=70) - puerperas with osteopenia, 2 (n=42) - puerperas with normal BMD. In the first group, osteopenia in the distal radius was observed in 48%, in the lumbar spine in 16% and in the proximal femur in 36%. Influence of the following possible factors in group 1 was established: BMI in 15-20 years ≤ 18 kg/m2 (p<0.013), BMI ≥ 25 kg/m2 (p<0.018), 25-OH-D less than 25 ng / ml (p < 0.0018), calcium intake less than 800 mg/day (p<0.041). Menstrual disorders (p<0.052) and preeclapsia (p < 0.042) affected lumbar spine BMD. In group 1, vitamin D deficiency was detected in 82% of women, 18% showed vitamin D insufficiency; in group 2, vitamin D deficiency was found in 16%, deficiency in 70%, in 14% vitamin D was normal. In women with a combination of factors such as BMI≤ 18 kg/m; calcium intake lower than 800 mg/day, menstrual cycle disorders, vitamin D deficiency - osteopenia in the distal radius occured 11 times more often (OR=11,47059; CI 95%=[4,0326; 32,627]). Conclusion: most significant impact on BMD decrease in puerperas can be expected if patient has the following risk factors: BMI≤18 kg/m2; 25-OH- D<25 ng/ml ; nutrition with calcium intake <800 mg per day, preeclampsia. Combination of these factors may increase the risk of osteopenia in the distal radius.

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The relationship between panoramic radiomorphometric indices of the mandible and calcaneus bone mineral density

Medicina ◽

10.3390/medicina46020014 ◽

2010 ◽

Vol 46 (2) ◽

pp. 95 ◽

Cited By ~ 9

Author(s):

Eglė Jagelavičienė ◽

Ričardas Kubilius ◽

Aurelija Krasauskienė

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Panoramic Radiography ◽

World Health ◽

Mineral Density ◽

X Ray ◽

Group 2 ◽

The Relationship ◽

Group 1

Objective. The aim of the study was to determine the relationship between bone mineral density in the calcaneus measured using the dual x-ray and laser osteodensitometry technique and bone mineral density in the mandible calculated using the panoramic radiomorphometric indices obtained by applying linear measurements in panoramic radiograms of postmenopausal women. Material and methods. The participants of this study were postmenopausal women (n=129) aged 50 and more. The subjects underwent panoramic radiography of the mandibles, followed by the calculation of the panoramic radiomorphometric indices indicating bone mineral density of the mandible. The dual x-ray and laser osteodensitometer DXL Calscan were used for the measurements of bone mineral density in the calcaneus. Statistical analysis was preformed to find the relationship between bone mineral density measurements in the two anatomically different bones. Results. Following the diagnostic criteria for osteoporosis recommended by the World Health Organization (1994), the subjects were distributed according to the calcaneus bone mineral density T-score into the normal bone mineral density (group 1), osteopenia (group 2), and osteoporosis (group 3) groups. Mean bone mineral density in the calcaneus in the general studied population was 0.38±0.07; the mean value of bone mineral density of the calcaneus in the group 1 (n=34) was 0.47±0.04 (g/cm²), in the group 2 (n=65) was 0.37±0.03 (g/cm²), and in the group 2 (n=30) was 0.29±0.03 (g/cm²). Differences in bone mineral density between the groups were determined using the analysis of variance (ANOVA) F=285.31; df=2; P<0.001 (T1 vs. T2, P<0.001; T1 vs. T3, P<0.001; T2 vs. T3; P<0.001). A statistically significant correlation was found in the general group between the mental index and bone mineral density in the calcaneus (r=0.356, P<0.001), and between the panoramic mandibular index and bone mineral density in the calcaneus (r=0.397, P<0.001). Conclusion. Bone mineral density in the calcaneus and the mandible measured using dual energy x-ray and laser osteodensitometer DXL Calscan and by applying panoramic radiography reflect general changes in the mineralization of these bones, characteristic of the postmenopausal period.

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Vitamin D deficiency and bone mineral density in postmenopausal women receiving aromatase inhibitors for early breast cancer

Maturitas ◽

10.1016/j.maturitas.2010.03.012 ◽

2010 ◽

Vol 66 (3) ◽

pp. 291-297 ◽

Cited By ~ 35

Author(s):

Xavier Nogues ◽

Sonia Servitja ◽

Maria Jesus Peña ◽

Daniel Prieto-Alhambra ◽

Rosa Nadal ◽

...

Keyword(s):

Breast Cancer ◽

Bone Mineral Density ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Postmenopausal Women ◽

Early Breast Cancer ◽

Bone Mineral ◽

Aromatase Inhibitors ◽

Mineral Density

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The effects of one-year simvastatin therapy on women’s bone mineral density

Open Medicine ◽

10.2478/s11536-010-1031-8 ◽

2010 ◽

Vol 5 (5) ◽

pp. 588-592 ◽

Cited By ~ 2

Author(s):

Aleksandar Dimic ◽

Dimitrije Jankovic ◽

Irena Jankovic ◽

Todorka Savic ◽

Nevena Karanovic

Keyword(s):

Risk Factors ◽

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Treated Group ◽

Mineral Density ◽

Simvastatin Therapy ◽

Group 2 ◽

One Year ◽

Group 1

AbstractOnly few studies have reported that bone fracture risk is decreased in hypercholesterolemic postmenopausal women treated with statin therapy. Because of a lack of longitudinal studies on the effect of statins on bones, the aim of our investigation was to estimate the simvastatin therapy effects on bone mineral density in hypercholesterolemic postmenopausal women. Our investigation was carried out on 53 postmenopausal women with hypercholesterolemia. The women included in the study were divided into two groups. Group 1 was comprised of women with two or more (n=32) atherosclerosis risk factors, whereas group 2 had women with less than two (n=21) of these risk factors. All the women included in the study were placed on a hypocholesterolemic diet and the women in group 1 were additionally treated with 20 mg of simvastatin daily. The parameters of lipid status, body mass index, and L2–L4 densitometry were determined at baseline and then after one year. The simvastatin-treated group showed significant improvement of lipid parameters and increased bone mineral density. Finally, changes in bone mineral density between the groups showed significant differences (p<0.05). Although our investigation was carried out on a small group, our results showed a positive effect of the simvastatin therapy on the bone mineral density of postmenopausal women.

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