scholarly journals Narcolepsy in childhood and adolescence

1991 ◽  
Vol 49 (3) ◽  
pp. 260-264 ◽  
Author(s):  
Rubens Reimão ◽  
Hélio Lemmi
Keyword(s):  
Daytime Sleepiness ◽  
Sleep Latency ◽  
Sudden Onset ◽  
Childhood And Adolescence ◽  
Sleep Paralysis ◽  
Short Sleep ◽  
Main Complaint ◽  
The Stability ◽  
Multiple Sleep Latency ◽  
Hypnagogic Hallucinations

The objective of this study was to evaluate clinical, polysomnography and the multiple sleep latency test (MSLT) features in young narcoleptics. We evaluated 14 patients with mean age of 13.6 years old (ranging from 6 to 18 years) ; 11 were males and 3 females. Daytime sleepiness was the main complaint in all cases and started at the ages of 6 to 17 years. Cataplexy was described in 10 cases and it was considered mild to moderate in all but one case. Sleep paralysis was present in 6 cases and hypnagogic hallucinations in 7 cases. The main polysomnography characteristics were the short sleep latency in 9 cases and the sudden onset of REM periods in 7 cases. The MSLT showed short or borderline sleep latencies in 13 cases, with a mean of 4.9 min; 2 or more REM periods were present in 13 cases. Clinical, polysomnographic and MSLT characteristics in the age bracket focused were remarkably similar to those of adult narcoleptics suggesting the stability of these psysiopa-thological markers.

scholarly journals Late-Onset Narcolepsy: A Case Report with Brief Review of the Literature

2021 ◽  
Author(s):  
Jeny Jacob ◽  
Rajesh Venkataram ◽  
Nandakishore Baikunje ◽  
Rashmi Soori
Keyword(s):  
Older Adults ◽  
Case Report ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Late Onset ◽  
Sleep Latency ◽  
Early Adulthood ◽  
Review Of The Literature ◽  
Multiple Sleep Latency ◽  
Overnight Polysomnography

AbstractNarcolepsy, a sleep disorder, has its onset in childhood and early adulthood but rarely in older adults. This case report focuses on a man in his late fifties who was noticed to have excessive daytime sleepiness during his stay in our hospital for an unrelated medical ailment. He was further evaluated with overnight polysomnography and next day multiple sleep latency test which confirmed the diagnosis of narcolepsy.

scholarly journals 1253 Multiple sleep onset REM episodes in middle age woman with excessive daytime sleepiness – Is this automatically assumed narcolepsy?

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A477-A477
Author(s):  
Kamal Patel ◽  
Bianca J Lang
Keyword(s):  
Daytime Sleepiness ◽  
Sleep Latency ◽  
Sleep Onset ◽  
Sleep Time ◽  
Multiple Sleep Latency Test ◽  
Sleep Onset Latency ◽  
Onset Latency ◽  
Obstructive Sleep ◽  
Falling Asleep ◽  
Multiple Sleep Latency

Abstract Introduction Presence of sleep onset REM episodes often raises concerns of narcolepsy. However other conditions have shown to have presence of sleep on REM episodes which include but not limited to obstructive sleep apnea, sleep wake schedule disturbance, alcoholism, neurodegenerative disorders, depression and anxiety Report of Case Here we present a case of 30 year old female with history of asthma, patent foraman ovale, migraine headache, and anxiety who presented with daytime sleepiness, falling asleep while at work, occasional scheduled naps, non-restorative sleep, sleep paralysis, and hypnopompic hallucination. Pertinent physical exam included; mallampati score of 4/4, retrognathia, high arched hard palate, crowded posterior oropharynx. She had a score of 16 on Epworth sleepiness scale. Patient previously had multiple sleep latency test at outside facility which revealed 4/5 SOREM, with mean sleep onset latency of 11.5 minutes. She however was diagnosed with narcolepsy and tried on modafinil which she failed to tolerate. She was tried on sertraline as well which was discontinued due to lack of benefit. She had repeat multiple sleep latency test work up which revealed 2/5 SOREM, with mean sleep onset latency was 13.1 minutes. Her overnight polysomnogram prior to repeat MSLT showed SOREM with sleep onset latency of 10 minutes. Actigraphy showed consistent sleep pattern overall with sufficient sleep time but was taking hydroxyzine and herbal medication. Patient did not meet criteria for hypersomnolence disorder and sleep disordered breathing. Conclusion There is possibility her medication may have played pivotal role with her daytime symptoms. We also emphasize SOREMs can be present in other disorders such as anxiety in this case and not solely in narcolepsy

Narcolepsy with cataplexy

2017 ◽  
Author(s):  
Gert Jan Lammers
Keyword(s):  
Excessive Daytime Sleepiness ◽  
Pharmacological Treatment ◽  
Clinical Symptoms ◽  
Sleep Latency ◽  
Daily Life ◽  
Sleep Stages ◽  
Nocturnal Sleep ◽  
Practical Guidelines ◽  
Multiple Sleep Latency ◽  
Hypnagogic Hallucinations

Narcolepsy with cataplexy is caused by disturbed cerebral hypocretin (also called orexin) transmission. It results in impaired physiological boundaries of wake and sleep stages and their specific components, leading to clinical symptoms such as excessive daytime sleepiness (EDS), impaired sustained attention, disturbed nocturnal sleep, cataplexy, and hypnagogic hallucinations. This chapter discusses the consequences for daily life of the disorder, the diagnostic challenges, particularly the interpretation of the results of the multiple sleep latency test (MSLT), the presumed cause and pathophysiology, the frequent comorbidities such as obesity, and practical guidelines for optimal nonpharmacological as well as pharmacological treatment.

scholarly journals Excessive daytime sleepiness in man: Multiple sleep latency measurement in narcoleptic and control subjects

1978 ◽  
Vol 45 (5) ◽  
pp. 621-627 ◽  
Author(s):  
Gary S Richardson ◽  
Mary A Carskadon ◽  
Wayne Flagg ◽  
Johanna Van den Hoed ◽  
William C Dement ◽  
...  
Keyword(s):  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Sleep Latency ◽  
Control Subjects ◽  
And Control ◽  
Multiple Sleep Latency

scholarly journals Oculomotor changes are associated to daytime sleepiness in the multiple sleep latency test

2005 ◽  
Vol 14 (2) ◽  
pp. 107-112 ◽  
Author(s):  
LUIGI DE GENNARO ◽  
ALESSANDRA DEVOTO ◽  
FABIO LUCIDI ◽  
CRISTIANO VIOLANI
Keyword(s):  
Daytime Sleepiness ◽  
Sleep Latency ◽  
Multiple Sleep Latency Test ◽  
Multiple Sleep Latency

scholarly journals Cancer-related fatigue presenting with excessive daytime sleepiness

2017 ◽  
Vol 5 ◽  
pp. 2050313X1774886
Author(s):  
Diwakar D Balachandran ◽  
Saadia A Faiz ◽  
Lara Bashoura ◽  
Ellen Manzullo
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Excessive Daytime Sleepiness ◽  
Breast Cancer Survivor ◽  
Daytime Sleepiness ◽  
Sleep Latency ◽  
Common Symptom ◽  
Cancer Related Fatigue ◽  
Multiple Sleep Latency ◽  
Multiple Sleep Latency Testing

Cancer-related fatigue is a common symptom in cancer patients which commonly occurs in relation to sleep disturbance. We report a case of a 35-year-old breast cancer survivor, in whom polysomnography and multiple sleep latency testing were utilized to objectively quantify the contribution of excessive daytime sleepiness to the patient’s cancer-related fatigue.

The influence of polysomnography on the Multiple Sleep Latency Test and other measures of daytime sleepiness

2002 ◽  
Vol 75 (1-2) ◽  
pp. 183-188 ◽  
Author(s):  
Adam Wichniak ◽  
Peter Geisler ◽  
Ferenc Tracik ◽  
Tatjana Crönlein ◽  
Sean P Morrissey ◽  
...  
Keyword(s):  
Daytime Sleepiness ◽  
Sleep Latency ◽  
Multiple Sleep Latency Test ◽  
Multiple Sleep Latency

Daytime Sleepiness in Adults With ADHD

2016 ◽  
Vol 20 (12) ◽  
pp. 1023-1029 ◽  
Author(s):  
Esther Sobanski ◽  
Barbara Alm ◽  
Oliver Hennig ◽  
Dieter Riemann ◽  
Bernd Feige ◽  
...  
Keyword(s):  
Daytime Sleepiness ◽  
Epworth Sleepiness Scale ◽  
Adult Adhd ◽  
Sleep Latency ◽  
Multiple Sleep Latency Test ◽  
Adhd Symptoms ◽  
Adhd Subtype ◽  
Multiple Sleep Latency

Objective: To evaluate sleep latency (SL) during the multiple sleep latency test (MSLT) and subjective daytime sleepiness in adult ADHD and controls. Method: Subjective daytime sleepiness was assessed by Epworth Sleepiness Scale (ESS) in 27 unmedicated adults with ADHD and in 182 controls. Thirteen ADHD patients and 26 controls underwent MSLT after one night of polysomnography (PSG). Results: Mean MSLT-SL was 10.6 ± 4.8 min in ADHD and 12.2 ± 4.2 min in controls (n.s.). Mean ESS score was 9.3 ± 4.9 points in ADHD and 6.9 ± 3.4 points in controls ( p < .005). MSLT-SL and ESS scores correlated inversely by trend ( r = −.45, p < .1) but not with ADHD symptoms or ADHD subtype. Conclusion: Adults with ADHD do not differ from controls in mean MSLT-SL but experience increased subjective daytime sleepiness. Patients with subjective higher daytime tiredness fell asleep faster during MSLT.

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