scholarly journals Enterovirus and herpesviridae family as etiologic agents of lymphomonocytary meningitis, Southern Brazil

2011 ◽  
Vol 69 (3) ◽  
pp. 475-481 ◽  
Author(s):  
Luine Rosele Renaud Vidal ◽  
Sérgio Monteiro de Almeida ◽  
Iara José de Messias-Reason ◽  
Meri Bordignon Nogueira ◽  
Maria do Carmo Debur ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Herpes Virus ◽  
Viral Meningitis ◽  
Etiologic Agent ◽  
Herpes Simplex Virus 1 ◽  
Virus Family ◽  
Barr Virus ◽  
Epstein Barr ◽  
Herpès Virus ◽  
Simplex Virus

Viral meningitis is a common infectious disease of the central nervous system (CNS) that occurs worldwide. The aim of this study was to identify the etiologic agent of lymphomonocytary meningitis in Curitiba, PR, Brazil. During the period of July 2005 to December 2006, 460 cerebrospinal fluid (CSF) samples with lymphomonocytary meningitis were analyzed by PCR methodologies. Fifty nine (12.8%) samples were positive. Enteroviruses was present in 49 (83%) samples and herpes virus family in 10 (17%), of these 6 (10%) herpes simplex virus, 1 (2%) Epstein Barr virus, 2 (3%) human herpes virus type 6 and 1 (2%) mixed infection of enterovirus and Epstein Barr virus. As conclusion enterovirus was the most frequent virus, with circulation during summer and was observed with higher frequency between 4 to 17 years of age. PCR methodology is an important method for rapid detection of RNA enterovirus and DNA herpesvirus in CSF.

scholarly journals Profound CD4+ T lymphocytopenia in human immunodeficiency virus negative individuals, improved with anti-human herpes virus treatment

2012 ◽  
pp. 305-311 ◽  
Author(s):  
María Lilia Diaz Betancourth ◽  
Julio Cesar Klinger ◽  
Victoria Eugenia Niño
Keyword(s):  
Human Immunodeficiency Virus ◽  
Epstein Barr Virus ◽  
Herpes Virus ◽  
Viral Infections ◽  
Human Herpes ◽  
Barr Virus ◽  
Human Herpes Virus ◽  
Immunodeficiency Virus ◽  
Epstein Barr ◽  
Herpès Virus

Lymphocytopenia and CD4+ T lymphocytopenia can be associated with many bacterial, fungal, parasite and viral infections. They can also be found in autoimmune and neoplastic diseases, common variable immu­nodeficiency syndrome, physical, psychological and traumatic stress, malnutrition and immunosuppressive therapy. Besides, they can also be brought into relation, without a known cause, with idiopathic CD4+ T lym­phocytopenia. Among viral infections, the Retrovirus, specially the human immunodeficiency virus, is the most frequently cause. However, many acute viral infections, including cytomegalovirus and Epstein Barr virus can be associated with transient lymphocytopenia and CD4+ T lymphocytopenia. As is well known, transient lymphocytopenia and CD4+ T lymphocytopenia are temporary and overcome when the disease improves. Nonetheless, severe CD4+ T Lymphocytopenia associated with chronic infections by human herpes virus has not been reported. We describe 6 cases of human immunodeficiency virus negative patients, with chronic cytomegalovirus and Epstein Barr virus infections and profound lymphocytopenia with clinical symptoms of cellular immunodeficiency. These patients improved rapidly with ganciclovir or valganciclovir treatment. We claim here that it is important to consider the chronic human herpes virus infection in the differential diag­nosis of profoundly CD4+ T lymphocytopenia etiology, when human immunodeficiency virus is absent, in order to start effective treatment and to determine, in future studies, the impact of chronic human herpes virus infection in human beings’ health.

The Biochemistry of Bereavement: Possible Basis for Chemotherapy?

1983 ◽  
Vol 13 (4) ◽  
pp. 295-303 ◽  
Author(s):  
Jerome F. Fredrick
Keyword(s):  
Infectious Disease ◽  
Epstein Barr Virus ◽  
Herpes Virus ◽  
Barr Virus ◽  
Adrenal Axis ◽  
Epstein Barr ◽  
Herpès Virus ◽  
Pituitary Adrenal Axis ◽  
Increased Susceptibility

The effect of acute grief on the pituitary-adrenal axis and the hypersecretion of cortisol is reviewed. Particular attention is devoted to the immunosuppressive effects of this hypersecretion. The increased susceptibility to infectious disease agents—bacterial, fungal and viral—is explored in terms of the altered biochemistry of the bereaved individual. The probable increased susceptibility towards oncogenic “passenger” viruses, such as the Epstein-Barr Virus and the Herpes Virus, is discussed as a possible mechanism for the increased incidence of malignancies in the bereaved. The use of dexamethasone in preventing hypersecretion of cortisol in the bereaved, as well as the use of L-dopa and clonidine to control A.C.T.H. levels in such individuals, has given rise to much conflicting data in recent studies. The use of antibiotics in a prophylactic sense, to bolster falling immunity during the grief period, remains a distinct possibility. However, until the basic reactions of grief are defined and the altered biochemistry established, it appears that psychological methods offer the best therapeutic means.

scholarly journals Epstein–Barr Virus and Human Herpes Virus-8 are not Associated with Juvenile Nasopharyngeal Angiofibroma

2008 ◽  
Vol 2 (3) ◽  
pp. 145-149 ◽  
Author(s):  
Román Carlos ◽  
Lester D. R. Thompson ◽  
Ana Carolina Netto ◽  
Luiz Gustavo Garcia Santos Pimenta ◽  
Jeane de Fátima Correia-Silva ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Herpes Virus ◽  
Juvenile Nasopharyngeal Angiofibroma ◽  
Human Herpes ◽  
Nasopharyngeal Angiofibroma ◽  
Human Herpes Virus 8 ◽  
Barr Virus ◽  
Human Herpes Virus ◽  
Epstein Barr ◽  
Herpès Virus

scholarly journals Molecular diagnosis of cytomegalovirus, Epstein-Barr virus and Herpes virus 6 among blood donors in Ouagadougou, Burkina Faso

2014 ◽  
Vol 14 (S2) ◽  
Author(s):  
Lassina Traore ◽  
Issoufou Tao ◽  
Cyrille Bisseye ◽  
Florencia Djigma ◽  
Djénéba Ouermi ◽  
...  
Keyword(s):  
Burkina Faso ◽  
Molecular Diagnosis ◽  
Epstein Barr Virus ◽  
Herpes Virus ◽  
Blood Donors ◽  
Barr Virus ◽  
Epstein Barr ◽  
Herpès Virus

scholarly journals Characterization and Intracellular Trafficking of Epstein-Barr Virus BBLF1, a Protein Involved in Virion Maturation

2012 ◽  
Vol 86 (18) ◽  
pp. 9647-9655 ◽  
Author(s):  
Ya-Fang Chiu ◽  
Bill Sugden ◽  
Pey-Jium Chang ◽  
Lee-Wen Chen ◽  
Ying-Ju Lin ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Retrograde Transport ◽  
Lytic Replication ◽  
Herpes Simplex Virus 1 ◽  
Virus Particles ◽  
Tegument Proteins ◽  
Barr Virus ◽  
Viral Maturation ◽  
Epstein Barr ◽  
Simplex Virus

Epstein-Barr virus (EBV) BBLF1 shares 13 to 15% amino acid sequence identities with the herpes simplex virus 1 UL11 and cytomegalovirus UL99 tegument proteins, which are involved in the final envelopment during viral maturation. This study demonstrates that BBLF1 is a myristoylated and palmitoylated protein, as are UL11 and UL99. Myristoylation of BBLF1 both facilitates its membrane anchoring and stabilizes it. BBLF1 is shown to localize to thetrans-Golgi network (TGN) along with gp350/220, a site where final envelopment of EBV particles takes place. The localization of BBLF1 at the TGN requires myristoylation and two acidic clusters, which interact with PACS-1, a cytosolic protein, to mediate retrograde transport from the endosomes to the TGN. Knockdown of the expression of BBLF1 during EBV lytic replication reduces the production of virus particles, demonstrating the requirement of BBLF1 to achieve optimal production of virus particles. BBLF1 is hypothesized to facilitate the budding of tegumented capsid into glycoprotein-embedded membrane during viral maturation.

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