scholarly journals p53, estrogen and progesterone receptors in diagnostic curettage for endometrial adenocarcinoma and their correlation with morphological data and disease stage at hysterectomy

2003 ◽  
Vol 121 (4) ◽  
pp. 163-166 ◽  
Author(s):  
Vera Lúcia Leite Bonfitto ◽  
Liliana Aparecida Lucci de Angelo Andrade
Keyword(s):  
Endometrial Carcinoma ◽  
Histological Grade ◽  
Endometrial Adenocarcinoma ◽  
Progesterone Receptors ◽  
Histological Type ◽  
Morphological Data ◽  
Disease Stage ◽  
Biological Behavior ◽  
Endometrioid Carcinoma ◽  
Estrogen And Progesterone Receptors

CONTEXT: Diagnostic staging is an important prognostic factor for endometrial adenocarcinoma. Apart from the histological type and histological grade, some markers seem to be associated with the stage and biological behavior of the disease. Among these are p53, estrogen and progesterone receptors. OBJECTIVE: The objectives of the present study were: to compare histological type and grading of endometrial carcinoma in curettage and hysterectomy samples; to assess expression of p53, estrogen and progesterone receptors in curettage specimens; and to correlate these data with morphology and staging of the disease in hysterectomy specimens. TYPE OF STUDY: Retrospective. SETTING: Department of Pathology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas. SAMPLE: Histological diagnosis from 51 consecutive files. PROCEDURES: Immunohistochemical reactions for p53, estrogen and progesterone receptors via the avidin-biotin-peroxidase method in 51 curettage samples endometrial carcinoma were compared with the morphological data and disease stage in hysterectomy. Marker expression was correlated with histological type and grade and the final stage of the disease. RESULTS: According to the histological type: 44 cases (86%) were of endometrioid and 7 (14%) non-endometrioid carcinoma. p53 expression was observed in 16% of endometrioid and 71% of non-endometrioid cases (p < 0.05). Although estrogen expression was more evident in endometrioid (54%) than non-endometrioid cases (29%), this was not statistically significant. Progesterone receptor expression was significantly higher in endometrioid than non-endometrioid cases (70% vs. 14%, p < 0.05). According to the histological grade: Estrogen and progesterone receptors were expressed more frequently in grade I endometrioid carcinoma, while p53 was mainly reported in tumor grades II and III. According to final disease stage: p53 and estrogen expression in curettage specimens was not related to stage; progesterone receptors, however, were expressed significantly less in advanced disease. CONCLUSION: p53 was observed in the majority of non-endometrioid and in high-grade endometrioid carcinoma, but was not related to stage. Estrogen and progesterone receptors were mainly found in grade I endometrioid carcinoma. The markers studied in curettage were no more valuable for predicting the disease stage than classical histological criteria.

scholarly journals Mesonephric-Like Differentiation of Endometrial Endometrioid Carcinoma: Clinicopathological and Molecular Characteristics Distinct from Those of Uterine Mesonephric-Like Adenocarcinoma

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1450
Author(s):  
Sujin Park ◽  
Go Eun Bae ◽  
Jiyoung Kim ◽  
Hyun-Soo Kim
Keyword(s):  
Endometrial Carcinoma ◽  
Progesterone Receptors ◽  
Growth Patterns ◽  
Targeted Sequencing ◽  
Biological Behavior ◽  
Histological Evaluation ◽  
Molecular Characteristics ◽  
Endometrioid Carcinoma ◽  
Kras Mutations ◽  
Prognostic Implications

When diagnosing endometrial carcinoma cases, we encountered histological features that strikingly resembled uterine mesonephric-like adenocarcinoma (MLA), but the differential diagnosis remained challenging after performing immunostaining. Considering the aggressive biological behavior and poor prognosis of uterine MLA, we believe that the accurate recognition of mesonephric-like differentiation (MLD) is important in the diagnosis of endometrial carcinoma. We aimed to investigate the clinicopathological and molecular characteristics of such cases and compared them with those of uterine MLAs. Five patients diagnosed with endometrioid carcinoma (EC) with MLD were included in this study. Histological evaluation, immunostaining, and targeted sequencing were performed. All five tumors showed typical morphological features of MLA, including densely aggregated tubular structures, deep basophilia under low-power magnification microscopy, eosinophilic intraluminal secretions, and diverse growth patterns. Immunostaining revealed moderate-to-strong nuclear immunoreactivity for estrogen and progesterone receptors in more than 50% tumor cells. The staining intensities and proportions of PAX2 and GATA3 were variable. None of the tumors harbored KRAS mutations. Considering the prognostic implications, ancillary tests, including immunostaining and targeted sequencing, should be performed to accurately differentiate between endometrial EC-MLD and uterine MLA.

Clinical associations of estrogen and progesterone receptors in endometrial adenocarcinoma

1985 ◽  
Vol 20 (2) ◽  
pp. 256-257
Author(s):  
M.B. Hasselquist ◽  
J.R. Lurain ◽  
C.B. Wallemark ◽  
A. Molteni ◽  
W.W. Hauck ◽  
...  
Keyword(s):  
Endometrial Adenocarcinoma ◽  
Progesterone Receptors ◽  
Estrogen And Progesterone Receptors ◽  
Clinical Associations

scholarly journals Clinic-pathological characteristics of colonic carcinoma in relation to localization and histologic type

2007 ◽  
Vol 64 (12) ◽  
pp. 827-831
Author(s):  
Vesna Zivkovic ◽  
Vuka Katic ◽  
Biljana Djordjevic ◽  
Miljan Krstic ◽  
Svetlana Pejovic ◽  
...  
Keyword(s):  
Alcian Blue ◽  
Histological Grade ◽  
Colon Adenocarcinoma ◽  
Tumor Stage ◽  
Histological Type ◽  
Colonic Carcinoma ◽  
Disease Stage ◽  
Lower Grade ◽  
Younger Patients ◽  
Number Of Patients

Background/Aim. A significant increase in colonic carcinoma has been analyzed in numerous clinic-pathological studies and genetics models. The aim of this study was to determinate the differences in clinic-pathological parameters of colonic carcinoma regarding localization and histological type. Methods. The study enrolled 124 patients who had undergone surgery for colorectal carcinoma at the Clinic of Surgery in the town of Nis within 2005. Paraffin sections were stained with Hematoxilin-eosin (H&E), High iron diamine-Alcian blue (HID-AB) (pH-2.5) and Alcian blue-Preiodic arid Shiff (AB-PAS) (pH-2.5) methods. From pathological report we used data regarding: localization (right or left colon), histological type, histological grade, and parameters which determinate the tumor stage. Results. The total number of patients with right-sided colonic carcinoma was 40 (32.36%) and 84 (67.74%) with left-sided colonic carcinoma. Histopathologically, 96 (77.42%) adenocarcinomas and 28 (22.58%) mucinous adenocarcinomas were verified. There were no statistically significant differences between the right-sided and left-sided colonic carcinoma regarding sex, age, histological grade and tumor stage (p > 0.05). Mucinous adenocarcinomas was statistically significantly more frequent in right-sided colon (35.00%) than in left-sided colon (16.67%) (p < 0.05). There were no statistically significant differences between adenocarcinomas and mucinous adenocarcinomas regarding sex and disease stage. In younger patients the percentage of mucinous adenocarcinomas (28.57%) compared to nonmucinous ones (11.46%) was significantlly higher (p < 0.05) than in older patients. Mucinous adenocarcinomas had statistically significantly more frequently poor differentiation in comparison to adenocarcinomas (46.43% versus 9.37%, p < 0.001). Conclusion. According to the presented results it can be concluded that the lower grade of differentiation of the colon adenocarcinoma and mucinous secretion are significantly often present in younger patients.

scholarly journals Assessment of HER-2 status in invasive breast cancer in Brazil

2017 ◽  
Vol 63 (7) ◽  
pp. 566-574
Author(s):  
Victor Eduardo Arrua Arias ◽  
Helenice Gobbi ◽  
Sérgio Ossamu Ioshii ◽  
Cristovam Scapulatempo ◽  
Alexandre Rolim da Paz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Histological Grade ◽  
Menopausal Status ◽  
Progesterone Receptors ◽  
Radical Mastectomy ◽  
Histological Type ◽  
Tubule Formation ◽  
The North ◽  
Her 2

Summary Objective: To characterize the frequency of HER-2-positive breast cancer in Brazil. Method: In this prospective observational study, we first ascertained the HER-2 status of invasive breast cancer specimens by automated immunohistochemistry (IHC). For specimens classified as 2+ by IHC, we performed in situ hybridization (ISH). Results: From February, 2011 to December, 2012, 1,495 breast specimens were registered, and 1,310 samples collected at 24 centers were analyzed. Median patient age was 54 years, and the majority of samples were obtained from segmental (46.9%) or radical mastectomy (34.4%). The predominant histological type was invasive breast carcinoma of no special type (85%), 64.3% had tubule formation (grade 3), and estrogen/progesterone receptors (ER/PR) were positive in 77.4/67.8% of the specimens analyzed, respectively. Using IHC, we found a negative HER-2 status (0 or 1+) in 72.2% of specimens, and 3+ in 18.5%; the 9.3% scored as 2+ were further analyzed by ISH, of which 15.7% were positive (thus, 20.0% of samples were HER-2- -positive by either method). We found no association between HER-2 scores and menopausal status or histological type. Tumors classified as 3+ came from younger patients, and had higher histological grade and less frequent expression of ER/PR. In the North region of Brazil, 34.7% of samples were 3+, with lower frequencies in the other four regions of the country. Conclusion: Our findings provide estimates for the frequency of HER-2 positivity in Brazil and raise the hypothesis that biological differences may underlie the different distribution of breast-cancer phenotypes among different Brazilian regions.

Estrogen and Progesterone Receptors in Endometrial Carcinoma

1993 ◽  
Vol 12 (3) ◽  
pp. 246-252 ◽  
Author(s):  
Henrik G. J. Nyholm ◽  
Anette L. Nielsen ◽  
Jens Lyndrup ◽  
Anne Dreisler ◽  
Susan M. Thorpe
Keyword(s):  
Endometrial Carcinoma ◽  
Progesterone Receptors ◽  
Estrogen And Progesterone Receptors
Sign in / Sign up

Export Citation Format

Share Document