scholarly journals Mesonephric-Like Differentiation of Endometrial Endometrioid Carcinoma: Clinicopathological and Molecular Characteristics Distinct from Those of Uterine Mesonephric-Like Adenocarcinoma

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1450
Author(s):  
Sujin Park ◽  
Go Eun Bae ◽  
Jiyoung Kim ◽  
Hyun-Soo Kim
Keyword(s):  
Endometrial Carcinoma ◽  
Progesterone Receptors ◽  
Growth Patterns ◽  
Targeted Sequencing ◽  
Biological Behavior ◽  
Histological Evaluation ◽  
Molecular Characteristics ◽  
Endometrioid Carcinoma ◽  
Kras Mutations ◽  
Prognostic Implications

When diagnosing endometrial carcinoma cases, we encountered histological features that strikingly resembled uterine mesonephric-like adenocarcinoma (MLA), but the differential diagnosis remained challenging after performing immunostaining. Considering the aggressive biological behavior and poor prognosis of uterine MLA, we believe that the accurate recognition of mesonephric-like differentiation (MLD) is important in the diagnosis of endometrial carcinoma. We aimed to investigate the clinicopathological and molecular characteristics of such cases and compared them with those of uterine MLAs. Five patients diagnosed with endometrioid carcinoma (EC) with MLD were included in this study. Histological evaluation, immunostaining, and targeted sequencing were performed. All five tumors showed typical morphological features of MLA, including densely aggregated tubular structures, deep basophilia under low-power magnification microscopy, eosinophilic intraluminal secretions, and diverse growth patterns. Immunostaining revealed moderate-to-strong nuclear immunoreactivity for estrogen and progesterone receptors in more than 50% tumor cells. The staining intensities and proportions of PAX2 and GATA3 were variable. None of the tumors harbored KRAS mutations. Considering the prognostic implications, ancillary tests, including immunostaining and targeted sequencing, should be performed to accurately differentiate between endometrial EC-MLD and uterine MLA.

scholarly journals p53, estrogen and progesterone receptors in diagnostic curettage for endometrial adenocarcinoma and their correlation with morphological data and disease stage at hysterectomy

2003 ◽  
Vol 121 (4) ◽  
pp. 163-166 ◽  
Author(s):  
Vera Lúcia Leite Bonfitto ◽  
Liliana Aparecida Lucci de Angelo Andrade
Keyword(s):  
Endometrial Carcinoma ◽  
Histological Grade ◽  
Endometrial Adenocarcinoma ◽  
Progesterone Receptors ◽  
Histological Type ◽  
Morphological Data ◽  
Disease Stage ◽  
Biological Behavior ◽  
Endometrioid Carcinoma ◽  
Estrogen And Progesterone Receptors

CONTEXT: Diagnostic staging is an important prognostic factor for endometrial adenocarcinoma. Apart from the histological type and histological grade, some markers seem to be associated with the stage and biological behavior of the disease. Among these are p53, estrogen and progesterone receptors. OBJECTIVE: The objectives of the present study were: to compare histological type and grading of endometrial carcinoma in curettage and hysterectomy samples; to assess expression of p53, estrogen and progesterone receptors in curettage specimens; and to correlate these data with morphology and staging of the disease in hysterectomy specimens. TYPE OF STUDY: Retrospective. SETTING: Department of Pathology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas. SAMPLE: Histological diagnosis from 51 consecutive files. PROCEDURES: Immunohistochemical reactions for p53, estrogen and progesterone receptors via the avidin-biotin-peroxidase method in 51 curettage samples endometrial carcinoma were compared with the morphological data and disease stage in hysterectomy. Marker expression was correlated with histological type and grade and the final stage of the disease. RESULTS: According to the histological type: 44 cases (86%) were of endometrioid and 7 (14%) non-endometrioid carcinoma. p53 expression was observed in 16% of endometrioid and 71% of non-endometrioid cases (p < 0.05). Although estrogen expression was more evident in endometrioid (54%) than non-endometrioid cases (29%), this was not statistically significant. Progesterone receptor expression was significantly higher in endometrioid than non-endometrioid cases (70% vs. 14%, p < 0.05). According to the histological grade: Estrogen and progesterone receptors were expressed more frequently in grade I endometrioid carcinoma, while p53 was mainly reported in tumor grades II and III. According to final disease stage: p53 and estrogen expression in curettage specimens was not related to stage; progesterone receptors, however, were expressed significantly less in advanced disease. CONCLUSION: p53 was observed in the majority of non-endometrioid and in high-grade endometrioid carcinoma, but was not related to stage. Estrogen and progesterone receptors were mainly found in grade I endometrioid carcinoma. The markers studied in curettage were no more valuable for predicting the disease stage than classical histological criteria.

scholarly journals α-Fetoprotein-Producing Endometrial Carcinoma Is Associated With Fetal Gut-Like and/or Hepatoid Morphology, Lymphovascular Infiltration, TP53 Abnormalities, and Poor Prognosis: Five Cases and Literature Review

2021 ◽  
Vol 8 ◽  
Author(s):  
Tomoyuki Otani ◽  
Kosuke Murakami ◽  
Naoki Shiraishi ◽  
Man Hagiyama ◽  
Takao Satou ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Early Stage ◽  
Direct Sequencing ◽  
Elevated Serum ◽  
Progesterone Receptors ◽  
Stage I ◽  
Molecular Characteristics ◽  
Gynecology And Obstetrics ◽  
Napsin A

The clinicopathological, immunohistochemical, and molecular characteristics of α-fetoprotein (AFP)-producing endometrial carcinoma (AFP+ EC) are poorly understood. From 284 cases of endometrial carcinoma in our pathology archive, we identified five cases (1.8%) of AFP+ EC with fetal gut–like (4/5) and/or hepatoid (2/5) morphology. All cases exhibited lymphovascular infiltration. In addition, 24 cases of endometrial carcinoma with elevated serum AFP levels were retrieved from the literature. The patient age ranged from 44 to 86 years (median: 63). Of 26 cases whose FIGO (International Federation of Gynecology and Obstetrics) stage and follow-up information was available (mean follow-up 24 months), 15 were stage I or II and 11 were stage III or IV. Even in stage I or II disease, death or relapse occurred in more than half of the patients (8/15). Detailed analysis of our five cases revealed that, on immunohistochemistry, AFP+ EC was positive for SALL4 (4/5), AFP (3/5), and HNF1β (4/5) in &gt;50% of neoplastic cells and negative for estrogen and progesterone receptors (5/5), PAX8 (4/5), and napsin A (5/5). Four cases exhibited aberrant p53 immunohistochemistry and were confirmed to harbor TP53 mutations by direct sequencing. No mutation was found in POLE, CTNNB1, or KRAS. In conclusion, AFP+ EC merits recognition as a distinct subtype of endometrial carcinoma, which occurs in 1.8% of endometrial carcinoma cases, are associated with TP53 abnormalities, exhibit lymphovascular infiltration, and can show distant metastasis even when treated in early stage.

scholarly journals Molecular-based classification algorithm for endometrial carcinoma categorizes ovarian endometrioid carcinoma into prognostically significant groups

2017 ◽  
Vol 30 (12) ◽  
pp. 1748-1759 ◽  
Author(s):  
Carlos Parra-Herran ◽  
Jordan Lerner-Ellis ◽  
Bin Xu ◽  
Sam Khalouei ◽  
Dina Bassiouny ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Classification Algorithm ◽  
Endometrioid Carcinoma

Dedifferentiated endometrial carcinoma: molecular characteristics and clinical outcomes

2021 ◽  
Vol 162 ◽  
pp. S123
Author(s):  
David Barrington ◽  
Adrian Suarez ◽  
Casey Cosgrove ◽  
Paul Goodfellow
Keyword(s):  
Endometrial Carcinoma ◽  
Clinical Outcomes ◽  
Molecular Characteristics

Endometrial lymphoepitheliomalike carcinoma: absence of Epstein–Barr virus genomes

2007 ◽  
Vol 17 (2) ◽  
pp. 532-535 ◽  
Author(s):  
S. Rahimi ◽  
A. Lena ◽  
G. Vittori
Keyword(s):  
Endometrial Carcinoma ◽  
Epstein Barr Virus ◽  
Neuron Specific Enolase ◽  
Progesterone Receptors ◽  
Figo Stage ◽  
Barr Virus ◽  
Ebv Infection ◽  
Endometrial Tumor ◽  
Epstein Barr ◽  
Virus Genomes

The aim of this study was to report a case of primary lymphoepitheliomalike endometrial carcinoma (FIGO stage IB). A 57-year-old woman presented with an endometrial tumor showing the classic clinical and hysteroscopic aspects of endometrial carcinoma. Morphologically, the neoplasm was similar to undifferentiated nasopharyngeal carcinoma (lymphoepithelioma). Immunohistochemistry showed that the tumor cells were cyokeratins and epithelial membrane antigen positive. Leucocyte common antigen, estrogen and progesterone receptors, neuron specific enolase, cromogranin, synaptophysin, and p53 were negative. We did not find evidence of Epstein–Barr virus (EBV) infection using immunohistochemistry and polymerase chain reaction (PCR). We report the third case of an endometrial lymphoepitheliomalike carcinoma (LELC). The patient did not receive chemotherapy and is alive and free of disease 24 month after diagnosis. LELC can occur in the endometrium and in this location may not be associated with EBV infection

Detection of a novel gene mutation, ERBB2 exon 20 insertion, in bronchial adenoma using next-generation sequencing and a review of the literature

2020 ◽  
Author(s):  
Qian Wu ◽  
Lin Li ◽  
Ke Zheng ◽  
Yuan Tang ◽  
Lili Jiang
Keyword(s):  
Computed Tomography ◽  
Next Generation Sequencing ◽  
Biological Behavior ◽  
Molecular Characteristics ◽  
Neoplastic Disease ◽  
Next Generation ◽  
Computed Tomography Images ◽  
Exon 20 ◽  
Generation Sequencing ◽  
Bronchial Adenoma

Abstract Objectives: Ciliated muconodular papillary tumor (CMPT) is a rare peripheral lung tumor and is a subtype of bronchial adenoma (BA). Although recent studies have suggested that BA is a neoplastic disease, the complete histogenesis of BA is not fully understood and molecular data are limited. Methods: We examined the clinicopathological features of four patients with BA and performed immunohistochemical analysis and next-generation sequencing to characterize the molecular features of BA. A review of the previous literature was also undertaken to comprehensively conclude the molecular characteristics of this disease. Results: From previous studies and the present study, 99 BA /CMPT cases have been reported to date, with most of the patients from East Asia (77/99, 77.8%). The median age was 64 years old and the ages ranged from 19 to 84 years. The proportion of males and females was close, being approximately 1:1.3. From the computed tomography images, the BA /CMPT tumor usually presented as a peripheral solid mass, part-solid nodules, or ground-glass opaque with an irregular border and occasional central cavities. ERBB2, EGFR, BRAF, and AKT1 mutations were found on the computed tomography images of the BAs. To the best of our knowledge, this is the first study to report about ERBB2 exon 20 insertion in BA. Conclusion: BA /CMPT is a rare pulmonary disease that mainly affects elderly Asian patients. Many abnormal molecular changes were found, which confirmed the neoplastic nature of BA /CMPT. However, it also added to the debate regarding the biological behavior of BA /CMPT.

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