The prognostic significance of estrogen and progesterone receptors in grade I and II endometrioid endometrial adenocarcinoma: hormone receptors in risk stratification

CONTEXT: Diagnostic staging is an important prognostic factor for endometrial adenocarcinoma. Apart from the histological type and histological grade, some markers seem to be associated with the stage and biological behavior of the disease. Among these are p53, estrogen and progesterone receptors. OBJECTIVE: The objectives of the present study were: to compare histological type and grading of endometrial carcinoma in curettage and hysterectomy samples; to assess expression of p53, estrogen and progesterone receptors in curettage specimens; and to correlate these data with morphology and staging of the disease in hysterectomy specimens. TYPE OF STUDY: Retrospective. SETTING: Department of Pathology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas. SAMPLE: Histological diagnosis from 51 consecutive files. PROCEDURES: Immunohistochemical reactions for p53, estrogen and progesterone receptors via the avidin-biotin-peroxidase method in 51 curettage samples endometrial carcinoma were compared with the morphological data and disease stage in hysterectomy. Marker expression was correlated with histological type and grade and the final stage of the disease. RESULTS: According to the histological type: 44 cases (86%) were of endometrioid and 7 (14%) non-endometrioid carcinoma. p53 expression was observed in 16% of endometrioid and 71% of non-endometrioid cases (p < 0.05). Although estrogen expression was more evident in endometrioid (54%) than non-endometrioid cases (29%), this was not statistically significant. Progesterone receptor expression was significantly higher in endometrioid than non-endometrioid cases (70% vs. 14%, p < 0.05). According to the histological grade: Estrogen and progesterone receptors were expressed more frequently in grade I endometrioid carcinoma, while p53 was mainly reported in tumor grades II and III. According to final disease stage: p53 and estrogen expression in curettage specimens was not related to stage; progesterone receptors, however, were expressed significantly less in advanced disease. CONCLUSION: p53 was observed in the majority of non-endometrioid and in high-grade endometrioid carcinoma, but was not related to stage. Estrogen and progesterone receptors were mainly found in grade I endometrioid carcinoma. The markers studied in curettage were no more valuable for predicting the disease stage than classical histological criteria.

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Hormone receptors in hepatoblastoma: A demonstration of both estrogen and progesterone receptors

Cancer ◽

10.1002/1097-0142(19821101)50:9<1828::aid-cncr2820500929>3.0.co;2-1 ◽

1982 ◽

Vol 50 (9) ◽

pp. 1828-1832 ◽

Cited By ~ 12

Author(s):

D. Jeffrey Demanes ◽

Michael A. Friedman ◽

James H. McKerrow ◽

Philip G. Hoffman

Keyword(s):

Hormone Receptors ◽

Progesterone Receptors ◽

Estrogen And Progesterone Receptors

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Prognostic significance of estrogen and progesterone receptors in stage ii breast cancer

Journal of Surgical Oncology ◽

10.1002/jso.2930370402 ◽

1988 ◽

Vol 37 (4) ◽

pp. 221-226 ◽

Cited By ~ 15

Author(s):

Stefan Rydén ◽

Mårten Fernö ◽

Åke Borg ◽

Larsolof Hafström ◽

Torgil Möller ◽

...

Keyword(s):

Breast Cancer ◽

Prognostic Significance ◽

Progesterone Receptors ◽

Stage Ii ◽

Estrogen And Progesterone Receptors

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A Review on Mammary Tumors in Rabbits: Translation of Pathology into Medical Care

Animals ◽

10.3390/ani9100762 ◽

2019 ◽

Vol 9 (10) ◽

pp. 762 ◽

Cited By ~ 3

Author(s):

Schöniger ◽

Degner ◽

Jasani ◽

Schoon

Keyword(s):

Prognostic Factors ◽

Lipid Droplets ◽

Prognostic Significance ◽

Progesterone Receptors ◽

Secretory Activity ◽

Surgical Excision ◽

Mammary Tumors ◽

Estrogen And Progesterone Receptors ◽

Age Range ◽

Microscopic Findings

The aim of this review is to raise awareness for mammary tumors in rabbits and to report progress in related research. Currently, a standardized tumor classification for rabbits is not available, prognostic factors are unknown and the only treatment option is surgical excision. Studies showed that affected rabbits have a wide age range and are nearly exclusively female or female spayed. Most mammary tumors are carcinomas. These may occur together with non-neoplastic or benign mammary lesions. Frequent microscopic findings are lipid droplets in tumor cells, secretory activity and microscopic heterogeneity. Since carcinomas are often negative for estrogen and progesterone receptors (ER-α/PR), modulation of receptor function will unlikely be beneficial for most rabbits. ER-α and PR status may have prognostic significance, since ER-α- or PR-negative tumors have significantly higher mitotic rates than ER-α- or PR-positive tumors. The frequent secretory activity of rabbit mammary tumors may suggest an influence of prolactin on tumorigenesis. Available data contribute to comparative pathology and are the basis for future molecular studies into the identification of additional prognostic factors and novel therapeutic options. They will also reveal the suitability of the rabbit as a model for certain types of breast cancer in women.

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Angiogenesis and expression of estrogen and progesterone receptors as predictive factors of recurrence in meningiomas: A long-term prospective study

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.e13013 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. e13013-e13013

Author(s):

D. Saavedra ◽

P. Guevara-Salazar ◽

E. Escobar-Arriaga ◽

A. Martinez-Rumayor ◽

D. Rembao ◽

...

Keyword(s):

Prospective Study ◽

Surgical Resection ◽

Predictive Factors ◽

Prognostic Significance ◽

Progesterone Receptors ◽

Tissue Expression ◽

Proliferation Index ◽

Vascular Density ◽

Histopathological Diagnosis ◽

Estrogen And Progesterone Receptors

e13013 Background: Meningioma is a bening tumor, with a high rate of recurrence after surgery (80%); the most important relapse predictive factor is the extent of surgical resection; other potentially predictive factors have been studied with poor results. Angiogenesis has an important role in growth and spread of neoplasic cells; previous studies have shown a high incidence of cyclin E (CE), estrogen, and progesterone receptors (ER, PR) in meningiomas. The aim of this prospective study was to evaluate the prognostic significance of clinical-pathological factors (CPF), vascular density index (VDI), cell proliferation index (CPI), CE, ER, and PR tissue expression in meningioma recurrence of patients submitted to surgical resection. Methods: From January 1995 to December 2000, we enrolled 42 patients with histopathological diagnosis of meningioma and treated only with surgical resection. Tumor VDI, CPI, CE, ER, and PR tissue expression were evaluated by immunohistochemistry in patients with or without recurrence. CPF, VDI, CPI, and expression of CE, ER, and PR were associated with recurrence. Results: Complete surgical resection was achieved in 32.5% of patients. Minimal follow-up was 6 years. Recurrence of meningioma was found in 17 patients (40%). Mean time of recurrence was 32 + 8 months. Tissue expression was positive for CE, ER, and PR in 90.9%, 27.6%, and in 64% of patients, respectively. VDI was >8 (40X in 10 fields) in 52.6% of patients and CPI was >600 (40X in 10 fields) in 54.2% of patients. Significant recurrence-associated factors were extent of resection (RR = 2.4, 95% CI 1.7–2.9, p = 0.03) and VDI >8 (RR = 1.7, 95% CI 1.003–2.9, p = 0.001). CPI, CE, ER, and PR expressions were not statistically significant (p = 0.83, p = 0.16, p = 0.46, and p = 0.74, respectively). Conclusions: Patients with partially resected meningioma and high VDI have an increased recurrence risk and could benefit of additional therapeutic measures. No significant financial relationships to disclose.

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Clinical associations of estrogen and progesterone receptors in endometrial adenocarcinoma

Gynecologic Oncology ◽

10.1016/0090-8258(85)90174-x ◽

1985 ◽

Vol 20 (2) ◽

pp. 256-257

Author(s):

M.B. Hasselquist ◽

J.R. Lurain ◽

C.B. Wallemark ◽

A. Molteni ◽

W.W. Hauck ◽

...

Keyword(s):

Endometrial Adenocarcinoma ◽

Progesterone Receptors ◽

Estrogen And Progesterone Receptors ◽

Clinical Associations

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313 The prognostic significance of estrogen-and progesterone receptors in breast cancer

Journal of Steroid Biochemistry ◽

10.1016/0022-4731(83)91813-7 ◽

1983 ◽

Vol 19 ◽

pp. 104

Author(s):

W. Eiermann ◽

P. Merl ◽

J. Jawny ◽

C. Tsoutsouiopouios

Keyword(s):

Breast Cancer ◽

Prognostic Significance ◽

Progesterone Receptors ◽

Estrogen And Progesterone Receptors

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Sex hormone receptors in varicose veins of women with premenstrual syndrome

Phlebologie ◽

10.1055/s-0037-1622215 ◽

2008 ◽

Vol 37 (02) ◽

pp. 68-72 ◽

Cited By ~ 1

Author(s):

L. Dzieciuchowicz ◽

M. Kotwicka ◽

M. Gabriel ◽

A. Szczęśniak-Chmielecka ◽

B. Krasińska ◽

...

Keyword(s):

Smooth Muscle ◽

Smooth Muscle Cells ◽

Sex Hormones ◽

Hormone Receptors ◽

Varicose Veins ◽

Progesterone Receptors ◽

Muscle Cells ◽

Sex Hormone ◽

Estrogen And Progesterone Receptors ◽

Premenstrual Tension

SummaryThe pathogenesis of premenstrual tension syndrome is not fully understood. It has been hypothesized that the interaction between sex hormones and target organs is the key event in its pathogenesis. Aim: The purpose of the study was to examine the differences in the prevalence of smooth muscle cells with sex hormones receptors in varicose veins of women with and without premenstrual tension syndrome (PS). Patients, methods: Samples of great saphenous vein were obtained from 50 women during varicose vein surgery. They were divided into group I (20 women with clinically diagnosed PS) and group II (30 women without PS). Estrogen and progesterone receptors were detected with an immunohistochemical method. Superficial densities of smooth muscle cells positive to estrogen and progesterone receptors were analyzed with densitometric program IM-AN and automatic image analyzer Magicall. The results were compared with t-Student test. Results: There were no differences in superficial density of smooth muscle cells positive to estrogen receptors between the groups. In contradiction to this, superficial density of smooth muscle cells positive to progesterone receptors was higher in group with PS than in patients without, 343 (±171) and 240 (±123), respectively. The difference was statistically significant (p < 0.05). Conclusion: The amount of cells with sex hormone receptors, not the level of hormones, could play a role in PS pathology. Our results show that progesterone is more important than estrogen in effector organs.

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