scholarly journals Epidermal Growth Factor Receptor Exon 20 Mutation Increased inPost-Chemotherapy Patients with Non-Small Cell Lung Cancer Detected with Patients' Blood Samples

2013 ◽  
Vol 6 (4) ◽  
pp. 504-510 ◽  
Author(s):  
Ying Wang ◽  
Wenlong Bao ◽  
Hua Shi ◽  
Chuming Jiang ◽  
Yongjun Zhang
Keyword(s):  
Lung Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Small Cell ◽  
Small Cell Lung ◽  
Blood Samples ◽  
Epidermal Growth ◽  
Chemotherapy Patients ◽  
Exon 20

Epidermal Growth Factor Receptor exon 20 insertion variants in Non-Small Cell Lung Cancer patients

2021 ◽  
pp. 103536
Author(s):  
Umberto Malapelle ◽  
Sara Pilotto ◽  
Maria Lucia Reale ◽  
Francesco Passiglia ◽  
Pasquale Pisapia ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients ◽  
Epidermal Growth ◽  
Exon 20

scholarly journals Epigenome-Wide Association Analysis of Differentially Methylated Signals in Blood Samples of Patients with Non-Small-Cell Lung Cancer

2019 ◽  
Vol 8 (9) ◽  
pp. 1307 ◽  
Author(s):  
Yoonki Hong ◽  
Hye-Mi Choi ◽  
Hyun Sub Cheong ◽  
Hyoung Doo Shin ◽  
Chang Min Choi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Methylation ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Early Diagnosis ◽  
Growth Factor Receptor ◽  
Small Cell ◽  
Small Cell Lung ◽  
Blood Samples ◽  
Epidermal Growth

Lung cancer is a common form of cancer and the leading cause of cancer-related deaths worldwide. Early diagnosis using noninvasive biomarkers may play an important role in increasing the survival rate of patients with lung cancer. Biomarkers of DNA methylation in blood samples may improve the early diagnosis of lung cancer. Here, we used peripheral blood samples obtained from 150 patients diagnosed with non-small-cell lung cancer (NSCLC) and 150 healthy controls. The latter were selected by frequency matching with the 150 patients with NSCLC, based on age, sex, and smoking status. Genome-wide methylation profiles were obtained using a MethylationEPIC BeadChip Kit, which covers the 850k bp cytosine–phosphate–guanine site. This analysis showed two significant differentially methylated changes (cg12169243 [DPH6] and cg25429010 [IMP3]) associated with NSCLC in current smokers, six changes (cg09245319, cg17183999 [USP7], cg06366994 [CPE], cg24992236 [MEG9], cg22144719, and cg22448179 [epidermal growth factor receptor]) associated with epidermal growth factor receptor mutation in patients with adenocarcinoma, and four changes (cg25021476 [RSL24D1], cg04989085 [FAM113B], cg20905681 [CKAP4], and cg26379694) associated with advanced-stage NSCLC compared with stage I NSCLC. The validation of these DNA methylation changes and further research on the related genes may help develop easily accessible biomarkers for the early diagnosis or prognosis of NSCLC.

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