Aqueous Extract of Wood Ear Mushroom, Auricularia polytricha (Agaricomycetes), Demonstrated Antiepileptic Activity against Seizure Induced by Maximal Electroshock and Isoniazid in Experimental Animals

2019 ◽  
Vol 21 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Gaurav Gupta ◽  
Sachchidanand Pathak ◽  
Rajiv Dahiya ◽  
Rajendra Awasthi ◽  
Anurag Mishra ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Maximal Electroshock ◽  
Experimental Animals ◽  
Auricularia Polytricha ◽  
Antiepileptic Activity

Green Synthesis and Characterization of Silver Nanoparticles using Glycine Max L. Seed Extract and their Antiepileptic Activity in Rats

2017 ◽  
Vol 10 (6) ◽  
pp. 3909-3914
Author(s):  
Imad Uddin Md ◽  
Kalyani D ◽  
Tejasri N ◽  
Mounika A ◽  
Sowndarya A ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Glycine Max ◽  
Zeta Potential ◽  
Aqueous Extract ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Maximal Electroshock ◽  
Antiepileptic Activity ◽  
Potential Formation

Glycine max is an edible oil seed and commonly known as Soybean. In this study, we report green, inexpensive method for synthesis of silver nanoparticles (SNPs) using of Glycine max seeds aqueous extract. Synthesized SNPs were characterized by UV-Visible spectroscopy (UV), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and Zeta Potential. Formation of Silver Nanoparticles from Glycine max Aqueous Extract (SNGMAE), indicated by appearance of dark brown color. UV depicted peak at 440nm, FTIR showed various functional groups present in plant extract capping in Silver Nanoparticles. Nanoparticle range of SNGMAE was identified by SEM and XRD, while stability was confirmed by Zeta Potential. Different constituents of aqueous extract viz., proteins, phytosterols, phospholipids, oils and carbohydrates are involved in the formation of SNPs. Synthesized SNGMAE was reconnoitered for antiepileptic activity in pentylenetetrazol (PTZ) and maximal electroshock induced epileptic (MESE) models, phenytoin (25mg/kg) was used as standard anti-epileptic drug. In negative control group of PTZ, all five stages of convulsions were observed, which were significantly reduced with phenytoin and with SNGMAE at 80 and 160mg/kg. MESE was characterized by appearance of flexion, extensor and clonus. In negative control group, these stages appeared for longer duration; these were decreased significantly in the treatment groups. In conclusion, these results show that SNGMAE may be a potent source of nanomedicine for the treatment of epilepsy.

Aphrodisiac Activity of an Aqueous Extract of Wood Ear Mushroom, Auricularia polytricha (Heterobasidiomycetes), in Male Rats

2018 ◽  
Vol 20 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Gaurav Gupta ◽  
Rakesh Kumar Sharma ◽  
Rajiv Dahiya ◽  
Anurag Mishra ◽  
Juhi Tiwari ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Male Rats ◽  
Auricularia Polytricha

The Protective Action of the Aqueous Extract of Auricularia polytricha in Paracetamol Induced Hepatotoxicity in Rats

2016 ◽  
Vol 10 (1) ◽  
pp. 72-76 ◽  
Author(s):  
Dinesh K. Chellappan ◽  
Sivamalar Ganasen ◽  
Shaminiswary Batumalai ◽  
Mayuren Candasamy ◽  
Purushotham Krishnappa ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Protective Action ◽  
Auricularia Polytricha

Immunomodulatory effects of aqueous extract of Tridax procumbens in experimental animals

2004 ◽  
Vol 92 (1) ◽  
pp. 113-119 ◽  
Author(s):  
Umesh Tiwari ◽  
Bhawna Rastogi ◽  
Paramjit Singh ◽  
Dinesh K. Saraf ◽  
Suresh P. Vyas
Keyword(s):  
Aqueous Extract ◽  
Immunomodulatory Effects ◽  
Experimental Animals ◽  
Tridax Procumbens

scholarly journals A Review on anti-epileptic activity of seaweed Ecklonia cava

2019 ◽  
Vol 9 (1-s) ◽  
pp. 425-432 ◽  
Author(s):  
Samiat Abimbola Owoalade ◽  
Diana Moria Martin Lou ◽  
Kashikant Yadav ◽  
Sumitra Poudel
Keyword(s):  
Anticonvulsant Activity ◽  
Wistar Rats ◽  
Wistar Rat ◽  
Epileptic Activity ◽  
Ecklonia Cava ◽  
Laboratory Animals ◽  
Maximal Electroshock ◽  
Antiepileptic Activity ◽  
Chemically Induced ◽  
Experimental Laboratory

The Present study was undertaken to investigate the Anticonvulsant activity of sea weed extract of Ecklonia cava on electrically and chemically induced seizures in wistar rat. The methanolic seaweed extract was studied for its anticonvulsant activity by using experimental paradigms like Maximal electroshock-induced seizures (MES). Expected to exhibited protection against tonic convulsions induced by MES in wistar rats. Objective of these studies were designed to screen the antiepileptic activity of the seaweed Ecklonia cava in experimental laboratory animals. Keywords: Antiepileptic Activity, Ecklonia cava (E.C), seizures, Flexon, Hind Limb Extension, Electroencephalography (EEG)

scholarly journals Preclinical evaluation of diuretic activity of aqueous extract of Solanum xanthocarpum leaves in experimental animals.

2013 ◽  
Vol 3 (4) ◽  
pp. 1023-1026 ◽  
Author(s):  
M.T. Deshmukh . ◽  
R.V. Shete . ◽  
V.T. Deshmukh . ◽  
S.R. Borate . ◽  
S.V. Deshmukh .
Keyword(s):  
Aqueous Extract ◽  
Diuretic Activity ◽  
Experimental Animals ◽  
Preclinical Evaluation ◽  
Solanum Xanthocarpum

scholarly journals EVALUATION OF THE ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF CENTELLA ASIATICA IN ALBINO MICE

2017 ◽  
Vol 9 (2) ◽  
pp. 312
Author(s):  
Dipjyoti Deka ◽  
Pinaki Chakravarty ◽  
Ayan Purkayastha
Keyword(s):  
Aqueous Extract ◽  
Hind Limb ◽  
Centella Asiatica ◽  
Control Group ◽  
Anticonvulsant Effect ◽  
Maximal Electroshock ◽  
Absence Seizures ◽  
Seizure Models ◽  
Clonic Convulsions ◽  
One Way Anova

<p><strong>Objective: </strong>To evaluate the antiepileptic activity of aqueous extract of <em>Centella asciatica</em> in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced convulsions. <strong></strong></p><p><strong>Methods</strong><strong>: </strong>The anticonvulsant activity of leaves of <em>Centella asciatica </em>(200 mg/kg and 400 mg/kg) in mice was assessed using MES and PTZ induced seizure models. Abolition of tonic hind limb extension (MES and PTZ) and increase in seizure latency (PTZ) when compared to control group, were taken as a measure of protection. Statistical analysis was done using one-way ANOVA followed by Tukey-Kramer multiple comparisons test. The test was considered to be significant at p&lt;0.05.</p><p><strong>Results</strong><strong>: </strong>The aqueous extract of <em>Centella asiatica</em> at a dose of 200 mg/kg has abolished tonic hind limb extension in 1 out of 6 animals in MES while there was no anticonvulsant action in PTZ convulsions. At a dose of 400 mg/kg body weight, the aqueous extract of <em>Centella asiatica</em> has shown a significant anticonvulsant effect against both MES and PTZ convulsions, where it has abolished tonic hind limb extension in 4 mice in MES method and in all 6 mices in PTZ method.</p><p><strong>Conclusion</strong><strong>: </strong>The aqueous extract of <em>Centella asiatica</em> showed efficacy in both MES and PTZ convulsions in mice at a dose of 400 mg/kg. Since the clinical correlates of MES seizures are tonic-clonic convulsions and correlates of PTZ seizures are absence seizures, the aqueous extract of <em>Centella asiatica</em> is likely to be useful in the treatment of tonic-clonic and absence seizures.</p>

Sign in / Sign up

Export Citation Format

Share Document