Thirteen-Week Oral Toxicity Evaluation of Erinacine AEnriched Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Mycelia in Sprague-Dawley Rats

2019 ◽  
Vol 21 (4) ◽  
pp. 401-411 ◽  
Author(s):  
Li-Ya Lee ◽  
I-Chen Li ◽  
Wan-Ping Chen ◽  
Yueh-Ting Tsai ◽  
Chin-Chu Chen ◽  
...  
2014 ◽  
Vol 70 ◽  
pp. 157-162 ◽  
Author(s):  
E.E. Owaga ◽  
M.J. Chen ◽  
W.Y. Chen ◽  
C.W. Chen ◽  
R.H. Hsieh

1990 ◽  
Vol 110 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Kenneth A. Voss ◽  
William P. Norred ◽  
Dorothy M. Hinton ◽  
Richard J. Cole ◽  
Joe W. Dorner

2020 ◽  
Vol 7 ◽  
pp. 1616-1621
Author(s):  
Mahedi Hasan ◽  
Abdullah Al Mahmud ◽  
Md. Jahir Alam ◽  
Shafayet Ahmed Siddiqui ◽  
Md. Saiful Islam Arman ◽  
...  

2013 ◽  
Vol 32 (5) ◽  
pp. 385-394 ◽  
Author(s):  
Antoinette Y. Odendaal ◽  
Narendra S. Deshmukh ◽  
Tennille K. Marx ◽  
Alexander G. Schauss ◽  
John R. Endres ◽  
...  

This toxicological assessment evaluated the safety of a hydroethanolic extract prepared from Caralluma fimbriata (CFE), a dietary supplement marketed worldwide as an appetite suppressant. Studies included 2 in vitro genotoxicity assays, a repeated dose oral toxicity study, and a developmental study in rats. No evidence of in vitro mutagenicity or clastogenicity surfaced in the in vitro studies at concentrations up to 5000 μg of extract/plate (Ames test) or 5000 μg of extract/mL (chromosomal aberration test). No deaths or treatment-related toxicity were seen in the 6-month chronic oral toxicity study in Sprague-Dawley rats conducted at 3 doses (100, 300, and 1000 mg/kg body weight (bw)/d). The no observed effect level for CFE in this study was considered to be 1000 mg/kg bw/d. A prenatal developmental toxicity study conducted at 3 doses (250, 500, and 1000 mg/kg bw/d) in female Sprague-Dawley rats resulted in no treatment-related external, visceral, or skeletal fetal abnormalities, and no treatment-related maternal or pregnancy alterations were seen at and up to the maximum dose tested. CFE was not associated with any toxicity or adverse events.


2010 ◽  
Vol 196 ◽  
pp. S269-S270
Author(s):  
R. Gámez ◽  
A. Gutiérrez ◽  
D.F. Arencibia ◽  
B. Pardo ◽  
M. Noa ◽  
...  

Author(s):  
Saad Alkahtani ◽  
Md Saquib Hasnain ◽  
Hamzah Algamdy ◽  
Nada H. Aljarba ◽  
Abdullah AlKahtane

2003 ◽  
Vol 24 (4) ◽  
pp. 231-240 ◽  
Author(s):  
Moon-Koo Chung ◽  
Jong-Choon Kim ◽  
Sung-Ho Myung ◽  
Dong-Il Lee

2016 ◽  
Vol 81 ◽  
pp. 275-283 ◽  
Author(s):  
A.M. Saillenfait ◽  
F. Marquet ◽  
J.P. Sabaté ◽  
D. Ndiaye ◽  
A.M. Lambert-Xolin

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