Subchronic oral toxicity of cyclopiazonic acid (CPA) in male Sprague-Dawley rats

This toxicological assessment evaluated the safety of a hydroethanolic extract prepared from Caralluma fimbriata (CFE), a dietary supplement marketed worldwide as an appetite suppressant. Studies included 2 in vitro genotoxicity assays, a repeated dose oral toxicity study, and a developmental study in rats. No evidence of in vitro mutagenicity or clastogenicity surfaced in the in vitro studies at concentrations up to 5000 μg of extract/plate (Ames test) or 5000 μg of extract/mL (chromosomal aberration test). No deaths or treatment-related toxicity were seen in the 6-month chronic oral toxicity study in Sprague-Dawley rats conducted at 3 doses (100, 300, and 1000 mg/kg body weight (bw)/d). The no observed effect level for CFE in this study was considered to be 1000 mg/kg bw/d. A prenatal developmental toxicity study conducted at 3 doses (250, 500, and 1000 mg/kg bw/d) in female Sprague-Dawley rats resulted in no treatment-related external, visceral, or skeletal fetal abnormalities, and no treatment-related maternal or pregnancy alterations were seen at and up to the maximum dose tested. CFE was not associated with any toxicity or adverse events.

Download Full-text

One year oral toxicity of D-004, a lipid extract from Roystonea regia fruits, in Sprague–Dawley rats

Toxicology Letters ◽

10.1016/j.toxlet.2010.03.894 ◽

2010 ◽

Vol 196 ◽

pp. S269-S270

Author(s):

R. Gámez ◽

A. Gutiérrez ◽

D.F. Arencibia ◽

B. Pardo ◽

M. Noa ◽

...

Keyword(s):

Lipid Extract ◽

Sprague Dawley ◽

Oral Toxicity ◽

Sprague Dawley Rats ◽

One Year

Download Full-text

Acute and sub-acute oral toxicity Lagerstroemia speciosa in Sprague-Dawley rats

Saudi Journal of Biological Sciences ◽

10.1016/j.sjbs.2021.11.005 ◽

2021 ◽

Author(s):

Saad Alkahtani ◽

Md Saquib Hasnain ◽

Hamzah Algamdy ◽

Nada H. Aljarba ◽

Abdullah AlKahtane

Keyword(s):

Acute Oral Toxicity ◽

Sprague Dawley ◽

Oral Toxicity ◽

Lagerstroemia Speciosa ◽

Sprague Dawley Rats

Download Full-text

4-Week repeated dose oral toxicity study of N-ethyl-2-pyrrolidone in Sprague Dawley rats

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2016.09.011 ◽

2016 ◽

Vol 81 ◽

pp. 275-283 ◽

Cited By ~ 4

Author(s):

A.M. Saillenfait ◽

F. Marquet ◽

J.P. Sabaté ◽

D. Ndiaye ◽

A.M. Lambert-Xolin

Keyword(s):

Toxicity Study ◽

Repeated Dose ◽

Sprague Dawley ◽

Oral Toxicity ◽

Sprague Dawley Rats ◽

Dose Oral

Download Full-text

Subacute Oral Toxicity Assesment of Ethanol Extract ofMariposa christia vespertilionisLeaves in Male Sprague Dawley Rats

Toxicological Research ◽

10.5487/tr.2018.34.2.085 ◽

2018 ◽

Vol 34 (2) ◽

pp. 85-95 ◽

Cited By ~ 12

Author(s):

Syahirah Ahmad Sayuti Nurul ◽

Hamzah Hazilawati ◽

Rosly Shaari Mohd ◽

Farhan Hanif Reduan Mohd ◽

Mohamed Mustapha Noordin ◽

...

Keyword(s):

Ethanol Extract ◽

Sprague Dawley ◽

Oral Toxicity ◽

Sprague Dawley Rats

Download Full-text

Oral Toxicity of 3-Nitro-1,2,4-triazol-5-one in Rats

International Journal of Toxicology ◽

10.1177/1091581814567177 ◽

2015 ◽

Vol 34 (1) ◽

pp. 55-66 ◽

Cited By ~ 13

Author(s):

Lee C. B. Crouse ◽

Emily May Lent ◽

Glenn J. Leach

Keyword(s):

Adverse Effect ◽

Polyethylene Glycol ◽

Food Consumption ◽

Body Mass ◽

Sprague Dawley ◽

Oral Toxicity ◽

Sprague Dawley Rats ◽

Polyethylene Glycol 200 ◽

Effect Level ◽

Human Health Effects

3-Nitro-1,2,4-triazol-5-one (NTO), an insensitive explosive, was evaluated to assess potential environmental and human health effects. A 14-day oral toxicity study in Sprague-Dawley rats was conducted with NTO in polyethylene glycol -200 by gavage at doses of 0, 250, 500, 1000, 1500, or 2000 mg/kg-d. Body mass and food consumption decreased in males (2000 mg/kg-d), and testes mass was reduced at doses of 500 mg/kg-d and greater. Based on the findings in the 14-day study, a 90-day study was conducted at doses of 0, 30, 100, 315, or 1000 mg/kg-d NTO. There was no effect on food consumption, body mass, or neurobehavioral parameters. Males in the 315 and 1000 mg/kg-d groups had reduced testes mass with associated tubular degeneration and atrophy. The testicular effects were the most sensitive adverse effect and were used to derive a benchmark dose (BMD) of 70 mg/kg-d with a 10% effect level (BMDL10) of 40 mg/kg-d.

Download Full-text