scholarly journals Acute and sub-acute oral toxicity Lagerstroemia speciosa in Sprague-Dawley rats

2021 ◽  
Author(s):  
Saad Alkahtani ◽  
Md Saquib Hasnain ◽  
Hamzah Algamdy ◽  
Nada H. Aljarba ◽  
Abdullah AlKahtane
Keyword(s):  
Acute Oral Toxicity ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Lagerstroemia Speciosa ◽  
Sprague Dawley Rats

scholarly journals Acute oral toxicity study of wound healing drink from Ocimum tenuiflorum on adult female Sprague-Dawley rats

Food Research ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 390-393
Author(s):  
Rohini J. ◽  
Rabeta M.S. ◽  
Wan Ezumi M.F.
Keyword(s):  
Wound Healing ◽  
Histopathological Examination ◽  
Microscopy Study ◽  
Toxicity Study ◽  
Histopathological Study ◽  
Acute Oral Toxicity ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Ocimum Tenuiflorum

In this study, the extract of Ocimum tenuiflorum was formulated to promote wound healing and no acute toxicity study has been reported on this type of formulation. Acute oral toxicity results of the rats after administration of 5000 mg/kg body weight (BW) formulation showed no toxic effects and behavioural changes of the rats after 14 days of observation. On day 14, the rats were anaesthetized to collect the vital organs for histopathological examination. The microscopy study of the visceral organs of wound healing powder group shows no sign of toxicity in comparison to untreated rats organs. In conclusion, the result of the acute oral toxicity test of wound healing drink showed no sign of toxicity, as corroborated by a histopathological study.

scholarly journals Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats

2015 ◽  
Vol 7 (1) ◽  
pp. 38 ◽  
Author(s):  
MallikarjunaRao Pichika ◽  
MadhuKatyayani Balijepalli ◽  
Velan Suppaiah ◽  
An-me Chin ◽  
AyubaSunday Buru ◽  
...  
Keyword(s):  
Acute Oral Toxicity ◽  
Swietenia Macrophylla ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Toxicity Studies ◽  
Sprague Dawley Rats

scholarly journals Acute Oral Toxicity Testing of Ethyl Acetate Fraction from Garcinia mangostana Linn Extract in Sprague-Dawley Rats

2016 ◽  
Vol 10 (3) ◽  
pp. 261-264 ◽  
Author(s):  
F. Rahmayanti ◽  
D.F. Suniarti ◽  
Z.A. Mas`ud ◽  
B.M. Bachtiar ◽  
Y.S. Wimardhani ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Toxicity Testing ◽  
Ethyl Acetate Fraction ◽  
Acute Oral Toxicity ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Garcinia Mangostana ◽  
Sprague Dawley Rats

scholarly journals ACUTE ORAL TOXICITY, DERMAL IRRITATION AND EYE IRRITATION STUDY OF ECLIPTA ALBA AQUEOUS EXTRACT IN SPRAGUE DAWLEY RATS AND NEWZEALAND WHITE RABBITS

2016 ◽  
Vol 7 (6) ◽  
pp. 103-109 ◽  
Author(s):  
Arakere C Udayashankar ◽  
Sollepura B Rajini ◽  
Murali Nandhini ◽  
Y S Suhas ◽  
Siddapura R Niranjana ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Acute Oral Toxicity ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Eye Irritation ◽  
Eclipta Alba ◽  
Dermal Irritation ◽  
Sprague Dawley Rats

scholarly journals Acute oral toxicity of zein nanoparticles with encapsulated gamma oryzanol in Sprague Dawley rats

2021 ◽  
Vol 302 ◽  
pp. 02011
Author(s):  
Ubonphan Rodsuwan ◽  
Krittiya Thisayakorn ◽  
Benjawan Thumthanaruk ◽  
Savitri Vatanyoopaisarn ◽  
Dudsadee Uttapap ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Normal Growth ◽  
Oral Route ◽  
Female Rats ◽  
Acute Oral Toxicity ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
General Physical ◽  
Gamma Oryzanol

Gamma oryzanol (GO) is well known for its antioxidant activity and health-promoting benefits. The gamma oryzanol-loaded zein nanoparticles (GOZNs) were successfully prepared in our previous study. In the present work, the acute oral toxicity of GOZNs was evaluated based on OECD guideline 420. GOZNs were fabricated by the liquid-liquid dispersion and lyophilized. The samples displayed a mean diameter of 311.20±3.01 nm and high loading capacity of 311.22±7.97 to 322.69±5.67 mg-GO/g-powder after 42-day storage at -18oC. Healthy female Sprague Dawley rats (8 weeks of age) were used for the experiments. Five female rats were administered a single dose of 2,000 mg GO/kg body weight via the oral route. Observations of toxicity signs were recorded for the first 24 hours, and the changes in the general physical conditions were monitored for 14 days before the gross necropsy on day 15. The results show that Sprague Dawley rats exhibited normal growth, and neither mortality nor acute toxicity signs were observed throughout the study period. The findings revealed that GOZNs did not have acute toxicity and were safe when administered orally in Sprague Dawley rats for short periods with LD50 > 2,000 mg/kg.

Acute and Sub-acute Oral Toxicity of Hydroethanolic Root Extract ofAnnona stenophyllaEngl. and Diels in Sprague Dawley Rats

2015 ◽  
Vol 5 (5) ◽  
pp. 349-356 ◽  
Author(s):  
Lameck S. Chagonda ◽  
Munodawafa Tafadzwa ◽  
Tagwirei Dexter ◽  
Gadaga Louis ◽  
Gomo Exnevia ◽  
...  
Keyword(s):  
Root Extract ◽  
Acute Oral Toxicity ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats

scholarly journals Acute Toxicity and Dermal and Eye Irritation of the Aqueous and Hydroalcoholic Extracts of the Seeds of “Zapote”Pouteria mammosa(L.) Cronquist

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Carlos M. S. Dutok ◽  
Clara Azalea Berenguer-Rivas ◽  
Elizabeth Rodríguez-Leblanch ◽  
Liliana Pérez-Jackson ◽  
Idelsy Chil-Nuñez ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Side Reaction ◽  
Acute Oral Toxicity ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Eye Irritation ◽  
Hydroalcoholic Extract ◽  
Sprague Dawley Rats ◽  
The Common ◽  
New Zealand Rabbits

The common use ofPouteria mammosa(L.) Cronquist, “Mamey or Zapote,” in food and ethnobotanic medicine shows its low or absent toxicity as fruit extracts prepared from seeds. However, it is essential to conduct security trials to scientifically support their use in drug therapy. This study evaluated the aqueous and hydroalcoholic extract (25%) Acute Oral Toxicity, obtained from the seeds ofP. mammosa, in Sprague Dawley rats and dermal and eye irritability in New Zealand rabbits. The 404 and 405 acute dermal and eye irritation/corrosion guidelines were used, as well as the 423 Acute Oral Toxicity guideline, Acute Toxic Class Method of the Organization for Economic Cooperation and Development (OECD). The aqueous extract was located in the following category: not classified as toxic (CTA 5), while hydroalcoholic extract at 25% was classified as dangerous (CTA 4). Both extracts can be used without side reaction that irritates the skin which permitted classification as potentially not irritant.P. mammosain the two extracts caused mild and reversible eye irritation, and it was classified as slightly irritating.

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