Growth Factors and Gene Transfer with DNA Strand Technique in Tendon Healing

2002 ◽  
Vol 12 (2) ◽  
pp. 8
Author(s):  
Feng Zhang ◽  
William C. Lineaweaver
Keyword(s):  
Growth Factors ◽  
Gene Transfer ◽  
Tendon Healing ◽  
Dna Strand

DNA Strand Gene Transfer and Bone Healing

2002 ◽  
Vol 12 (2) ◽  
pp. 11 ◽  
Author(s):  
Feng Zhang ◽  
William C. Lineaweaver ◽  
Kenneth Fischer
Keyword(s):  
Gene Transfer ◽  
Bone Healing ◽  
Dna Strand

scholarly journals Gene Transfer and Expression of Platelet-derived Growth Factors Modulate Periodontal Cellular Activity

2001 ◽  
Vol 80 (3) ◽  
pp. 892-897 ◽  
Author(s):  
Z. Zhu ◽  
C.S. Lee ◽  
K.M. Tejeda ◽  
W.V. Giannobile
Keyword(s):  
Growth Factors ◽  
Gene Transfer ◽  
Cellular Activity

Response of the Injured Tendon to Growth Factors in the Presence or Absence of the Paratenon

2018 ◽  
Vol 47 (2) ◽  
pp. 462-467 ◽  
Author(s):  
Sebastian A. Müller ◽  
Nicholas P. Quirk ◽  
Julia A. Müller-Lebschi ◽  
Patricia E. Heisterbach ◽  
Lutz Dürselen ◽  
...  
Keyword(s):  
Growth Factors ◽  
Achilles Tendon ◽  
Platelet Rich Plasma ◽  
Tendon Repair ◽  
Tendon Healing ◽  
Cross Sectional ◽  
Autologous Conditioned Serum ◽  
Injured Tendon ◽  
The Right ◽  
Exogenous Growth Factors

Background: The paratenon is important for Achilles tendon healing. There is much interest in the use of exogenous growth factors (GFs) as potential agents for accelerating the healing of damaged Achilles tendons. Purpose/Hypothesis: The present study used a rat model to study the responses of the injured Achilles tendon to GFs in the presence or absence of the paratenon. The hypothesis was that responses of the injured tendon to GFs would be lower in the absence of a paratenon. Study Design: Controlled laboratory study. Methods: A 4-mm defect was created in the right Achilles tendon of 60 skeletally mature rats, which were treated with a validated combination of GFs (bFGF, BMP-12, and TGF-β1). Animals were randomly assigned to the intact paratenon (IP) group or resected paratenon (RP) group. Healing was studied anatomically, mechanically, and histologically after 1, 2, and 4 weeks. Results: IP tendons showed improved healing compared with RP tendons. IP tendons were significantly stronger (32.2 N and 48.9 N, respectively) than RP tendons (20.1 N and 31.1 N, respectively) after 1 and 2 weeks. IP tendons did not elongate as much as RP tendons and had greater cross-sectional areas (18.0 mm2, 14.4 mm2, and 16.4 mm2, respectively) after 1, 2, and 4 weeks compared with RP tendons (10.5 mm2, 8.4 mm2, and 11.9 mm2, respectively). On histology, earlier collagen deposition and parallel orientation of fibrils were found for IP tendons. Conclusion: The paratenon is essential for efficient Achilles tendon healing. Healing with GFs in this Achilles tendon defect model was superior in the presence of the paratenon. Clinical Relevance: Biological approaches to tendon engineering using GFs are in vogue and have been shown to improve healing of the rat Achilles tendon, most likely by inducing progenitor cells located within the paratenon. Clinically, resection or incision of the paratenon has been proposed for wound closure. Our data demonstrate the fundamental importance of the paratenon, which therefore should be preserved during Achilles tendon repair, especially if augmented with products such as platelet-rich plasma or autologous conditioned serum that are rich in GFs.

Supplementation-time Dependence of Growth Factors in Promoting Tendon Healing

2006 ◽  
Vol 448 ◽  
pp. 240-247 ◽  
Author(s):  
B P Chan ◽  
S C Fu ◽  
L Qin ◽  
C Rolf ◽  
K M Chan
Keyword(s):  
Growth Factors ◽  
Time Dependence ◽  
Tendon Healing

Synergistic growth factors enhance rat liver proliferation and enable retroviral gene transfer via a peripheral vein

2000 ◽  
Vol 118 (3) ◽  
pp. 591-598 ◽  
Author(s):  
Stuart J. Forbes ◽  
Mike Themis ◽  
Malcolm R. Alison ◽  
Ildiko Sarosi ◽  
Charles Coutelle ◽  
...  
Keyword(s):  
Growth Factors ◽  
Gene Transfer ◽  
Rat Liver ◽  
Peripheral Vein ◽  
Retroviral Gene Transfer ◽  
Liver Proliferation

Tendon Healing In Vivo: Gene Expression and Production of Multiple Growth Factors in Early Tendon Healing Period

2008 ◽  
Vol 33 (10) ◽  
pp. 1834-1842 ◽  
Author(s):  
Chuan Hao Chen ◽  
Yi Cao ◽  
Ya Fang Wu ◽  
Anthony J. Bais ◽  
Jing Song Gao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factors ◽  
Tendon Healing ◽  
Healing Period

Efficient and stable gene transfer of growth factors into chondrogenic cells and primary articular chondrocytes using a VSV.G pseudotyped retroviral vector

Biomaterials ◽  
2008 ◽  
Vol 29 (9) ◽  
pp. 1242-1249 ◽  
Author(s):  
Stephan Vogt ◽  
Peter Ueblacker ◽  
Christopher Geis ◽  
Bettina Wagner ◽  
Gabriele Wexel ◽  
...  
Keyword(s):  
Growth Factors ◽  
Gene Transfer ◽  
Articular Chondrocytes ◽  
Retroviral Vector ◽  
Stable Gene
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