scholarly journals Effects of smoking on regional cerebral blood flow in cerebral vascular disease patients and normal subjects.

1987 ◽  
Vol 151 (3) ◽  
pp. 261-268 ◽  
Author(s):  
KAZUO KUBOTA ◽  
TATSUO YAMAGUCHI ◽  
TAKEHIKO FUJIWARA ◽  
TAIJU MATSUZAWA
1983 ◽  
Vol 3 (4) ◽  
pp. 442-447 ◽  
Author(s):  
Lawrence C. McHenry ◽  
David A. Stump ◽  
George Howard ◽  
Thomas T. Novack ◽  
Don H. Bivins ◽  
...  

A single-blind study was conducted in 13 right-handed normal male subjects to compare the effects of oral and i.v. papaverine on regional cerebral blood flow (rCBF). Six xenon-133 inhalation rCBF measurements were performed on each subject; three tests—baseline, placebo, and drug evaluations—were carried out on each of two separate days. The oral and i.v. drugs were randomized for first-day administration. rCBF, measured as flow gray (FG), increased significantly (p ≤ 0.001) from baseline with both drug forms. Increases of 10.53% and 13.94% (left and right hemispheres, respectively) were demonstrated 90 min after a single 600-mg dose of oral papaverine. Increases of 5.09% and 8.69%, respectively, were recorded immediately after a single 100-mg dose of i. v. papaverine. FG also increased significantly (p ≤ 0.001) for both drug forms when compared to that of placebo. Placebo produced only a slight increase (not significant) with both the oral and i.v. groups. The data show that both oral and i.v. papaverine are equally effective in increasing rCBF in normal subjects.


1991 ◽  
Vol 4 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Guido Rodriguez ◽  
Richard Coppola ◽  
Fabrizio De Carli ◽  
Stefano Francione ◽  
Stefano Marenco ◽  
...  

Stroke ◽  
1974 ◽  
Vol 5 (6) ◽  
pp. 719-724 ◽  
Author(s):  
YOSHIHIRO KURIYAMA ◽  
TAKASHI AOYAMA ◽  
KUNIHIKO TADA ◽  
SHOTARO YONEDA ◽  
TADAATSU NUKADA ◽  
...  

1983 ◽  
Vol 143 (2) ◽  
pp. 128-132 ◽  
Author(s):  
P. Uytdenhoef ◽  
P. Portelange ◽  
J. Jacquy ◽  
G. Charles ◽  
P. Linkowski ◽  
...  

SummaryCerebral blood flow is known as an indicator of cerebral metabolism. Using the 133Xenon inhalation method, we studied the regional cerebral blood flow (r-CBF) in patients with different subtypes of depression and in remission. A left frontal hypervascularization and a right posterior hypovascularization were found in major depressives, compared to normal subjects, minor depressives, and normothymic bipolar patients. These results tend to confirm the existence of cerebral dysfunction in both hemispheres in major depression, as reported by other authors using different techniques.


1989 ◽  
Vol 9 (4) ◽  
pp. 461-470 ◽  
Author(s):  
Adriaan A. Lammertsma ◽  
Richard S. J. Frackowiak ◽  
John M. Hoffman ◽  
Sung-Cheng Huang ◽  
Irving N. Weinberg ◽  
...  

A new method to measure regional CBF (rCBF) and volume of distribution of water is presented. It centres on recording the tissue build-up and retention of 15O-labelled water during the continuous inhalation of 15O-labelled carbon dioxide. Simultaneously, the arterial concentration is continuously monitored, and corrections for delay and dispersion in the recorded response are made by curve fitting. The values for the volume of distribution of water obtained in four normal subjects were close to reported in vitro values. Using the same fixed distribution volumes for both build-up and steady-state studies resulted in comparable rCBF values for both techniques.


1986 ◽  
Vol 21 (10) ◽  
pp. 907-914 ◽  
Author(s):  
Roy J. Mathew ◽  
William H. Wilson ◽  
Stephen R. Tant

1989 ◽  
Vol 97 (3-4) ◽  
pp. 139-145 ◽  
Author(s):  
W. Sorteberg ◽  
K. -F. Lindegaard ◽  
K. Rootwelt ◽  
A. Dahl ◽  
R. Nyberg-Hansen ◽  
...  

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