Heterogeneity of Regional Cerebral Blood Flow and Regional Distribution of Relative Weights of Gray and White Matter in Normal Subjects

A single-blind study was conducted in 13 right-handed normal male subjects to compare the effects of oral and i.v. papaverine on regional cerebral blood flow (rCBF). Six xenon-133 inhalation rCBF measurements were performed on each subject; three tests—baseline, placebo, and drug evaluations—were carried out on each of two separate days. The oral and i.v. drugs were randomized for first-day administration. rCBF, measured as flow gray (FG), increased significantly (p ≤ 0.001) from baseline with both drug forms. Increases of 10.53% and 13.94% (left and right hemispheres, respectively) were demonstrated 90 min after a single 600-mg dose of oral papaverine. Increases of 5.09% and 8.69%, respectively, were recorded immediately after a single 100-mg dose of i. v. papaverine. FG also increased significantly (p ≤ 0.001) for both drug forms when compared to that of placebo. Placebo produced only a slight increase (not significant) with both the oral and i.v. groups. The data show that both oral and i.v. papaverine are equally effective in increasing rCBF in normal subjects.

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Regional Cerebral Blood Flow in Patients with Aneurysms: Estimation by Xenon 133 Inhalation

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100024380 ◽

1978 ◽

Vol 5 (3) ◽

pp. 301-305 ◽

Cited By ~ 29

Author(s):

Bryce Weir ◽

Devidas Menon ◽

Thomas Overton

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Regional Cerebral Blood Flow ◽

Normal Values ◽

Regional Distribution ◽

Progressive Increase ◽

Control Group ◽

Regional Cerebral Blood ◽

Progressive Reduction ◽

Distribution Of Flow

SUMMARY:Seventy six regional cerebral blood flow (rCBF) studies were conducted on 32 patients who had a total of 39 aneurysms. Twenty three of these patients were studied pre- and post-operatively. Normal values were obtained from a control group of 33 subjects, each of whom underwent one rCBF study. Flow was reduced following subarachnoid hemorrhage (SAH); it increased significantly postoperatively. Lower flows were associated with poorer clinical grades. There was a greater variation in regional distribution of flow immediately following SAH than in normals or in patients who had recovered from the acute phase. rCBF studies correlated with CT scans demonstrated that a progressive increase in ventricular size was accompanied by a progressive reduction in flow. In addition, intraventricular hemorrhage (IVH) was associated with a significant reduction in cerebral blood flow (CBF). No significant correlation between CBF and spasm was demonstrable.

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Pattern of white matter regional cerebral blood flow and autoregulation in normal pressure hydrocephalus

Brain ◽

10.1093/brain/awh131 ◽

2004 ◽

Vol 127 (5) ◽

pp. 965-972 ◽

Cited By ~ 151

Author(s):

Shahan Momjian ◽

Brian K. Owler ◽

Zofia Czosnyka ◽

Marek Czosnyka ◽

Alonso Pena ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

White Matter ◽

Normal Pressure Hydrocephalus ◽

Regional Cerebral Blood Flow ◽

Normal Pressure ◽

Regional Cerebral Blood

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Regional cerebral blood flow asymmetries in a group of 189 normal subjects at rest

Brain Topography ◽

10.1007/bf01129666 ◽

1991 ◽

Vol 4 (1) ◽

pp. 57-63 ◽

Cited By ~ 12

Author(s):

Guido Rodriguez ◽

Richard Coppola ◽

Fabrizio De Carli ◽

Stefano Francione ◽

Stefano Marenco ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Regional Cerebral Blood Flow ◽

Normal Subjects ◽

Regional Cerebral Blood

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Regional Cerebral Blood Flow and Lateralized Hemispheric Dysfunction in Depression

The British Journal of Psychiatry ◽

10.1192/bjp.143.2.128 ◽

1983 ◽

Vol 143 (2) ◽

pp. 128-132 ◽

Cited By ~ 72

Author(s):

P. Uytdenhoef ◽

P. Portelange ◽

J. Jacquy ◽

G. Charles ◽

P. Linkowski ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Major Depression ◽

Regional Cerebral Blood Flow ◽

Cerebral Metabolism ◽

Normal Subjects ◽

Regional Cerebral Blood ◽

Cerebral Dysfunction ◽

Bipolar Patients

SummaryCerebral blood flow is known as an indicator of cerebral metabolism. Using the 133Xenon inhalation method, we studied the regional cerebral blood flow (r-CBF) in patients with different subtypes of depression and in remission. A left frontal hypervascularization and a right posterior hypovascularization were found in major depressives, compared to normal subjects, minor depressives, and normothymic bipolar patients. These results tend to confirm the existence of cerebral dysfunction in both hemispheres in major depression, as reported by other authors using different techniques.

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Beagle pup model of brain injury: regional cerebral blood flow and cerebral prostaglandins

Journal of Neurosurgery ◽

10.3171/jns.1987.67.2.0278 ◽

1987 ◽

Vol 67 (2) ◽

pp. 278-283 ◽

Cited By ~ 11

Author(s):

Laura R. Ment ◽

William B. Stewart ◽

Charles C. Duncan ◽

Bruce R. Pitt ◽

Judith Cole

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Brain Injury ◽

White Matter ◽

Regional Cerebral Blood Flow ◽

Ventilatory Support ◽

Periventricular White Matter ◽

Regional Cerebral Blood ◽

Content Type ◽

Carbon 14

✓ Asphyxia is the most common cause of severe brain injury in very young children, and frequently results in lesions of the periventricular white matter in addition to other neuropathological changes. This study examines the effects of asphyxia on regional cerebral blood flow (rCBF) and the role of prostaglandins (PG's) in its control in the newborn beagle pup. Pups were anesthetized, tracheotomized, paralyzed, artificially ventilated, and randomly assigned to two groups: asphyxial insult produced by discontinuing ventilatory support, and no insult. Experiments for carbon-14-iodoantipyrine autoradiographic determination of rCBF and regional cerebral PG determination were performed on separate groups of pups. These studies demonstrated a significant increase in cortical gray PGE2 levels at a time when rCBF was significantly impaired in response to severe asphyxial insult. No such increase was noted in the periventricular white matter zones.

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The C15O2 Build-up Technique to Measure Regional Cerebral Blood Flow and Volume of Distribution of Water

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/jcbfm.1989.69 ◽

1989 ◽

Vol 9 (4) ◽

pp. 461-470 ◽

Cited By ~ 48

Author(s):

Adriaan A. Lammertsma ◽

Richard S. J. Frackowiak ◽

John M. Hoffman ◽

Sung-Cheng Huang ◽

Irving N. Weinberg ◽

...

Keyword(s):

Carbon Dioxide ◽

Blood Flow ◽

Cerebral Blood Flow ◽

Regional Cerebral Blood Flow ◽

Normal Subjects ◽

Volume Of Distribution ◽

Regional Cerebral Blood ◽

Arterial Concentration ◽

Fixed Distribution

A new method to measure regional CBF (rCBF) and volume of distribution of water is presented. It centres on recording the tissue build-up and retention of 15O-labelled water during the continuous inhalation of 15O-labelled carbon dioxide. Simultaneously, the arterial concentration is continuously monitored, and corrections for delay and dispersion in the recorded response are made by curve fitting. The values for the volume of distribution of water obtained in four normal subjects were close to reported in vitro values. Using the same fixed distribution volumes for both build-up and steady-state studies resulted in comparable rCBF values for both techniques.

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