scholarly journals Endocytosis in Rat Intrahepatic Bile Duct Epithelial Cells of Horseradish Peroxidase Injected into the Common Bile Duct or the Portal Vein.

1996 ◽  
Vol 180 (3) ◽  
pp. 197-208 ◽  
Author(s):  
Takeshi Yamamoto ◽  
Motoyasu Ishii ◽  
Takayoshi Toyota
Parasitology ◽  
1981 ◽  
Vol 83 (2) ◽  
pp. 253-258 ◽  
Author(s):  
John R. Foster

SUMMARYFollowing infection of rats with Fasciola hepatica, an increase in the number of epithelial cells in the common bile duct, labelled with [3H]thymidine, was detected autoradiographically as early as 5 days post-infection (p.i.). This initial mitogenic effect of the infection was limited to that region of the bile duct lying adjacent to the liver, while the region lying next to the duodenum failed to show any increase in labelling until 41 days p.i. Mechanical contact between the parasite and the biliary epithelium did not occur until 41 days p.i. and the initial hyperplasia was evidently not a result of mechanical irritation. The study serves to emphasize the chemical aetiology of the precocious biliary hyperplasia and to more accurately identify its onset.


1972 ◽  
Vol 25 (1) ◽  
pp. 155 ◽  
Author(s):  
I Caple ◽  
T Heath

Bile and pancreatic juice were collected from conscious, standing sheep with fistulae of the common bile duct, before and during infusions of secretin to the portal vein, and during infusion of acid to the duodenum. The output of volume and electrolytes, particularly bicarbonate, in bile and in pancreatic juice increased during infusion of secretin. However, the output of volume and of bicarbonate was three to five times higher in bile than in pancreatic juice. When acid was infused into the duodenum a similar result was obtained, and the increment in total bicarbonate output was similar to the amount of acid infused.


Rangifer ◽  
1990 ◽  
Vol 10 (1) ◽  
pp. 17
Author(s):  
Timo Rahko ◽  
Sven Nikander

<p>In a previous publication the authors have described some ultrastructural characteristics of granulated cells in the common bile duct of the reindeer. On the basis of the same material, electron microscopic observations on other tissue elements of bile duct wall are now reported. The surface and glandular epithelium were composed of tall columnar epithelial cells with villous structures on the luminal surfaces. The parietal cytoplasmic membranes of epithelial cells were equipped with intercellular desmosomes while intraepithelial globule leucocytes did not form any junctional complex with other cells. Apical cytoplasmic areas of superficial epithelial cells showed electron-dense small bodies possibly consisting of mucinous substances. The goblet and deep glandular cells, on the other hand, contained numerous large mucin granules with less electron-dense matrices. It appears that their secretions are more abundant than those in superficial epithelial cells which obviously are absorptive as their main function. The nuclei and other cytoplasmic organelles showed profiles similar to those in epithelial cells generally. The lumen of the bile ducts was usually empty or contained fine-granular or amorphous material. An unusual feature was the presence of parts of globule leucocytes or even almost whole cells occurring freely in ductal secretions.</p><p>Elektronimikroskooppinen tutkimus yhteisen sappik&auml;yt&auml;v&auml;n rakenteesta porolla.</p><p>Abstract in Finnish / Yhteenveto: Aikaisemmassa julkaisussa tekij&auml;t kuvasivat poron yhteisen sappik&auml;yt&auml;v&auml;n (<em>ductus hepaticus communis</em>) sein&auml;m&auml;n jyv&auml;sellisten solujen hienorakennetta. T&auml;ss&auml; artikkelissa selostetaan saman aineiston perusteella (6 tervett&auml; teurasporoa) elektronimikroskooppisia havaintoja sappik&auml;yt&auml;v&auml;sein&auml;m&auml;n muista kudosrakenteista. Sappik&auml;yt&auml;v&auml;sein&auml;m&auml;n pinta- ja rauhasepiteeli koostuu korkeista epiteelisoluista. Pinnallisia epiteelisoluja kattavat s&auml;&auml;nn&ouml;lliset mikrovillukset, ja niill&auml; on vain v&auml;h&auml;n ilmeisesti limaa sis&auml;lt&auml;vi&auml; jyv&auml;si&auml; solulimassaan. Rau-has- ja pikarisoluissa s&auml;&auml;nn&ouml;lliset mikrovillukset sen sijaan puuttuvat. Niiden sytoplasman t&auml;ytt&auml;v&auml;t runsaat li-mapalloset, joita solut muodostavat hyvin kehittyneess&auml; Golgin laitteessaan eritt&auml;en limaa sappik&auml;yt&auml;v&auml;n onte-loon. Erite n&auml;kyy hienojyv&auml;isen&auml; tai tasa-aineisena sein&auml;mi&auml; reunustavana aineena. Poikkeuksellisena havaintona voidaan pit&auml;&auml; ker&auml;ssolujen ker&auml;sten tai l&auml;hes kokonaisten ker&auml;ssolujen esiintymist&auml; sappik&auml;yt&auml;v&auml;on-teloissa mahdollisesti osoituksena solujen vaelluskyvyst&auml;. Vaikka epiteelisolut muodostavat lujia solukalvosi-doksia toisiinsa, ker&auml;ssolut eiv&auml;t kiinnittyneet muihin soluihin. Ilmeist&auml; on, ett&auml; pinnallisten epiteelisolujen toiminta on p&auml;&auml;asiassa absorptiivista, mutta rauhasepiteelisolut ovat erikoistuneet eritystoimintaan.</p><p>En elektronmikroskopisk studie av gallg&aring;ngen hos ren.</p><p>Abstract in Swedish / Sammandrag: Gallg&aring;ngarnas yt- och k&ouml;rtelepitel bestod av h&ouml;ga epitelceller bekl&auml;dda med ett regelbundet villusskikt. Intercellulara desmosomer s&aring;gs i epitelcellernas parietala cytoplasmamembraner. De intraepiteliala globulara leukocyterna saknade desmosomer eller andra bindningar med n&aring;rliggande celler. I de superficiala epitelcellernas apikala cytoplasma fanns elektrontata sm&aring; kroppar antagligen best&aring;ende av mucin. B&auml;gar- och de djupare belagna k&ouml;rtelcellerna inneholl rikligt med stora mucin granulor med ett mindre elektrontatt matrix. Det f&ouml;ref&ouml;ll som om dessa celler skulle vara sekrerande och de superficiala epitelcellerna absorberande. K&auml;rnen och andra cytoplasmatiska organeller hade egenskaper jamf&ouml;rbara med epitelceller i allm&auml;nhet. Gallg&aring;ngen var oftast tom men ibland s&aring;gs ett finkornigt amorft material i den. Som en anmarkningsvard observation ansees forekomsten av delar och t.o.m. hela globulara leukocyter i gallg&aring;ngen.</p>


2012 ◽  
Vol 255 (3) ◽  
pp. 523-527 ◽  
Author(s):  
Juliette C. Slieker ◽  
Waqar R. R. Farid ◽  
Casper H. J. van Eijck ◽  
Johan F. Lange ◽  
Jasper van Bommel ◽  
...  

2015 ◽  
Vol 100 (3) ◽  
pp. 480-485 ◽  
Author(s):  
Atsushi Miki ◽  
Yasunaru Sakuma ◽  
Hideyuki Ohzawa ◽  
Yukihiro Sanada ◽  
Hideki Sasanuma ◽  
...  

We report a rare case of immunoglobulin G4 (IgG4)–related sclerosing cholangitis without other organ involvement. A 69-year-old-man was referred for the evaluation of jaundice. Computed tomography revealed thickening of the bile duct wall, compressing the right portal vein. Endoscopic retrograde cholangiopancreatography showed a lesion extending from the proximal confluence of the common bile duct to the left and right hepatic ducts. Intraductal ultrasonography showed a bile duct mass invading the portal vein. Hilar bile duct cancer was initially diagnosed and percutaneous transhepatic portal vein embolization was performed, preceding a planned right hepatectomy. Strictures persisted despite steroid therapy. Therefore, partial resection of the common bile duct following choledochojejunostomy was performed. Histologic examination showed diffuse and severe lymphoplasmacytic infiltration, and abundant plasma cells, which stained positive for anti-IgG4 antibody. The final diagnosis was IgG4 sclerosing cholangitis. Types 3 and 4 IgG4 sclerosing cholangitis remains a challenge to differentiate from cholangiocarcinoma. A histopathologic diagnosis obtained with a less invasive approach avoided unnecessary hepatectomy.


1995 ◽  
Vol 36 (4-6) ◽  
pp. 388-392 ◽  
Author(s):  
Pétur H. Hannesson ◽  
Hans Stridbeck ◽  
Christer Lundstedt ◽  
Åke Andrén-Sandberg ◽  
Ingemar Ihse

The purpose of this study was to evaluate the appearance of the normal portal vein with intravascular ultrasound. The portal vein was studied in 10 patients with colorectal carcinoma without known liver or pancreatic disease. For the intravascular portovenous examination, a 2.0-mm, 20-MHz ultrasound catheter was used. The field of view was 30 mm. The wall of the portal vein appeared as a single hyperechoic layer 0.5 to 0.8 mm in thickness. Normal structures adjacent to the portal vein, such as the common bile duct, the hepatic artery or small lymph nodes, were clearly separated from the lumen of the portal vein by the wall of the vein together with some periportal fat. In most cases the parenchyma of the pancreas could be separated from the wall of the vein.


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