scholarly journals The Case Fatality Rate of Methicillin-Resistant Staphylococcus aureus (MRSA) Infection among the Elderly in a Geriatric Hospital and Their Risk Factors.

1997 ◽  
Vol 183 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Masakazu Washio ◽  
Chikako Kiyohara ◽  
Tadashi Hamada ◽  
Yoshihiro Miyake ◽  
Yumiko Arai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Case Fatality Rate ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Case Fatality ◽  
The Elderly ◽  
Fatality Rate ◽  
Methicillin Resistant ◽  
Geriatric Hospital ◽  
Mrsa Infection

Risk factors for methicillin-resistant staphylococcus aureus (MRSA) infection in a Japanese geriatric hospital

Public Health ◽  
1997 ◽  
Vol 111 (3) ◽  
pp. 187-190 ◽  
Author(s):  
M Washio ◽  
T Mizoue ◽  
T Kajioka ◽  
T Yoshimitsu ◽  
M Okayama ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant ◽  
Geriatric Hospital ◽  
Mrsa Infection

Risk factors for methicillin-resistant staphylococcus aureus (MRSA) infection in a Japanese geriatric hospital

Public Health ◽  
1997 ◽  
Vol 111 (3) ◽  
pp. 187-190 ◽  
Author(s):  
M Washio ◽  
T Mizoue ◽  
T Kajioka ◽  
T Yoshimitsu ◽  
M Okayama ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant ◽  
Geriatric Hospital ◽  
Mrsa Infection

scholarly journals 1230. Epidemiology and Risk Factors for Recurrent Invasive Methicillin-Resistant Staphylococcus aureus Infection: nine US States, 2006–2013

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S373-S374
Author(s):  
Ian Kracalik ◽  
Kelly Jackson ◽  
Joelle Nadle ◽  
Wendy Bamberg ◽  
Susan Petit ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Infection Type ◽  
The United States ◽  
Emerging Infections ◽  
Methicillin Resistant ◽  
Initial Infection ◽  
Joint Infections ◽  
Mrsa Infection

Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) causes >70,000 invasive infections annually in the United States, and recurrent infections pose a major clinical challenge. We examined risk factors for recurrent MRSA infections. Methods We identified patients with an initial invasive MRSA infection (isolation from a normally sterile body site) from 2006 to 2013, through active, population-based surveillance in selected counties in nine states through the Emerging Infections Program. Recurrence was defined as invasive MRSA isolation >30 days after initial isolation. We used logistic regression with backwards selection to evaluate adjusted odds ratios (aOR) associated with recurrence within 180 days, prior healthcare exposures, and initial infection type, controlling for patient demographics and comorbidities. Results Among 24,478 patients with invasive MRSA, 3,976 (16%) experienced a recurrence, including 61% (2,438) within 180 days. Risk factors for recurrence were: injection drug use (IDU) (aOR; 1.38, 95% confidence interval [CI]: 1.15–1.65), central venous catheters (aOR; 1.35, 95% CI: 1.22–1.51), dialysis (aOR; 2.00, 95% CI: 1.74–2.31), and history of MRSA colonization (aOR; 1.35, 95% CI: 1.22–1.51) (figure). Recurrence was more likely for bloodstream infections (BSI) without another infection (aOR; 2.08, 95% CI: 1.74–2.48), endocarditis (aOR; 1.46, 95% CI: 1.16–1.55), and bone/joint infections (aOR; 1.38, 95% CI: 1.20–1.59), and less likely for pneumonia (aOR: 0.75, 95% CI: 0.64–0.89), compared with other initial infection types. When assessed separately, the presence of a secondary BSI with another infection increased the odds of recurrence over that infection without a BSI (aOR: 1.96, 95% CI: 1.68–2.30). Conclusion Approximately one in six persons with invasive MRSA infection had recurrence. We identified potential opportunities to prevent recurrence through infection control (e.g., management and early removal of central catheters). Other possible areas for preventing recurrence include improving the management of patients with BSI and bone/joint infections (including both during and after antibiotic treatment) and mitigating risk of infection from IDU. Disclosures All authors: No reported disclosures.

Methicillin-resistant Staphylococcus aureus (MRSA) Infection in the Elderly

1993 ◽  
Vol 3 (2) ◽  
pp. 117-120 ◽  
Author(s):  
Tomoko Kajioka ◽  
Masakazu Washio ◽  
Takahiro Yoshimitsu ◽  
Tadashi Hamada ◽  
Yoshito Shogakiuchi ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
The Elderly ◽  
Methicillin Resistant ◽  
Mrsa Infection

Increasing rates of community-acquired methicillin-resistant Staphylococcus aureus infections among HIV-infected persons

2007 ◽  
Vol 18 (8) ◽  
pp. 521-526 ◽  
Author(s):  
Nancy F Crum-Cianflone ◽  
Alina A Burgi ◽  
Braden R Hale
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
General Population ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Incidence Rates ◽  
Hiv Viral Load ◽  
Syphilis Infection ◽  
Methicillin Resistant ◽  
History Of ◽  
Mrsa Infection

Community-acquired (CA) methicillin-resistant Staphylococcus aureus (MRSA) rates have rapidly increased in the general population; however, little data on recent incidence rates and risk factors of CA-MRSA infections among HIV patients appear in the literature. A retrospective study was conducted from 1993 through 2005 among patients at a large HIV clinic. Trends in CA-MRSA infection incidence rates, clinical characteristics and risk factors for CA-MRSA were evaluated. Seven percent of our cohort developed a CA-MRSA infection during the study period. The rate of CA-MRSA infections among HIV-infected population significantly increased since 2003, with an incidence of 40.3 cases/1000 person-years in 2005, which was 18-fold higher than the general population served at our facility. In all, 90% of infections were skin/soft tissue infections with a predilection for buttock or scrotal abscess formation; 21% of patients experienced a recurrent infection. Risk factors included a low CD4 count at the time of infection (odds ratio [OR] per 100 CD4 cells 0.84, P = 0.03), high maximum log10 HIV viral load (OR 4.54, P<0.001), recent use of β-lactam antibiotics (OR 6.0 for receipt of two prescriptions, P<0.001) and a history of syphilis (OR 4.55, P = 0.01). No patient receiving trimethoprim-sulfamethoxazole prophylaxis developed a CA-MRSA infection. Over the study period, CA-MRSA accounted for an increasing percentage of positive wound cultures and Staphylococcus aureus isolates, 37% and 65%, respectively, during 2005. In conclusion, CA-MRSA infections have rapidly increased among HIV-infected patients, a group which has a higher rate of these infections than the general population. Risk factors for CA-MRSA among HIV-infected patients include low current CD4 cell count, recent β-lactam antibiotic use and potentially high-risk sexual activity as demonstrated by a history of syphilis infection.

scholarly journals Risk factors for methicillin-resistant Staphylococcus aureus (MRSA) infection in a Japanese elderly care nursing home

1998 ◽  
Vol 120 (1) ◽  
pp. 115-115
Author(s):  
M. WASHIO
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Nursing Home ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Elderly Care ◽  
The Elderly ◽  
Japanese Elderly ◽  
Mrsa Infection ◽  
Epidemiol Infect ◽  
Care Nursing

Epidemiol. Infect.119, (1997), 285Correct last sentence to: ‘Unnecessary administration of antibiotics as well as unnecessary hospitalization is not advisable when treating the elderly in nursing homes.’

scholarly journals Necrotizing pneumonia caused by methicillin-resistant Staphylococcus aureus

2021 ◽  
Author(s):  
Toshiki Hiramatsu ◽  
Kazunori Tobino
Keyword(s):  
Staphylococcus Aureus ◽  
Progressive Disease ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Fatal Case ◽  
Case Fatality ◽  
Necrotizing Pneumonia ◽  
Methicillin Resistant ◽  
Appropriate Treatment ◽  
Mrsa Infection ◽  
Vancomycin Treatment

We report a fatal case of methicillin-resistant Staphylococcus aureus (MRSA)-induced necrotizing pneumonia that was refractory to adequate vancomycin treatment (trough value, 13.1 µg/mL), drainage of a hydropneumothorax, and veno-arterial extracorporeal membrane oxygenation. MRSA infection can cause rapidly progressive disease with a high case fatality rate, even with appropriate treatment.

scholarly journals The efficacy and safety of intravenous lincosamide therapy in methicillin-resistant Staphylococcus aureus bacteremia

2021 ◽  
Author(s):  
Isabel Guthridge ◽  
Simon Smith ◽  
Matthew Law ◽  
Enzo Binotto ◽  
Josh Hanson
Keyword(s):  
Staphylococcus Aureus ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Source Control ◽  
Fatality Rate ◽  
Efficacy And Safety ◽  
Tertiary Referral Hospital ◽  
Methicillin Resistant ◽  
Retrospective Audit ◽  
Alternative Regimen

Background: Methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia has a high case-fatality rate, but currently recommended antimicrobial therapies have many shortcomings. The efficacy and safety of lincosamide therapy for MRSA bacteraemia is incompletely defined. Materials and methods: A retrospective audit of the management of all adults with MRSA bacteraemia at an Australian tertiary-referral hospital between 1 January 2007 and 31 December 2020. Results: 176 patients were included. The case-fatality rate declined from 14/57 (25%) in the first half of the study to 12/119 (10%) in the second half (p=0.01). Of the 172 patients receiving antibiotics, 62 (36%) received a lincosamide-predominant regimen (lincosamide monotherapy for >50% of the intravenous course). The patients receiving lincosamide-predominant intravenous therapy had lower in-hospital mortality (odds ratio (OR): 0.07 (95% confidence interval (CI): 0.01-0.53), p=0.01) and a lower incidence of renal complications (OR (95% CI): 0.34 (0.15-0.75), p=0.008) than patients receiving an alternative regimen. In multivariate analysis that also considered age, disease severity, comorbidity, infectious diseases consultation, source control and the year of admission, patients receiving a lincosamide-predominant regimen were still less likely to die in hospital than those receiving an alternative regimen (OR (95% CI): 0.05 (0.00-0.65), p=0.02). Conclusions: Lincosamides appear to have utility - at least as stepdown therapy - in the treatment of MRSA bacteremia, particularly in young, clinically stable patients with few comorbidities in whom endocarditis has been excluded. Prospective studies will help define their optimal role.

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