In view of the shortcoming such as wiring difficulties, poor scalability, and big cable usage in present mine security monitoring system, this paper puts forward a kind of substation monitoring and control system based on ZIGBEE and CAN. With the core of core, The system collects various measurement data of sensors through the ZIGBEE wireless network, realizes the to collect, and then through the CAN bus to realize the transmission of control commands and data of the up and down machine, and monitor the production parameters and environmental parameters in the coal mine. Experiments show that the monitoring substation is of high real-time performance, good stability, strong expansibility, etc., and can meet the requirements of the coal mine development and mining.