Retention of normal ovarian function after hysterectomy

1992 ◽  
Vol 135 (3) ◽  
pp. 597-602 ◽  
Author(s):  
M. G. Metcalf ◽  
V. Braiden ◽  
J. H. Livesey
Keyword(s):  
Ovarian Function ◽  
Urine Samples ◽  
Long Term Effects ◽  
Ovulatory Cycle ◽  
Normal Women ◽  
Effect Of Age

ABSTRACT What are the long-term effects of hysterectomy on the ovaries of normal women? Ninety-three women aged 29–44 years (median, 38 years) who had undergone hysterectomy for benign reasons 0·3–9·1 years prior to investigation, contributed urine samples twice weekly for a period of 53–149 days (median 102 days) for pregnanediol analysis. The interval between successive pregnanediol peaks and their increment over baseline were measured. The median peak interval was 27·3 days, and 93·3% of all intervals were of 21- to 35-days duration. Of the 337 peaks observed, 96·7% met the criteria previously used to define an ovulatory cycle. These are similar to the figures reported for menstruant women of comparable age. ANOVA showed no significant effect of age or time since hysterectomy on either the interval between peaks or peak increment (P > 0·10 in all cases). The evidence suggests that the ovaries of women who have no uterus behave like those of intact women. Journal of Endocrinology (1992) 135, 597–602

scholarly journals Analysis of Aflatoxin Biomarkers in the Hair of Experimental Animals

Toxins ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 570
Author(s):  
Innocent Mupunga ◽  
Ilse Janse van Rensburg ◽  
Nokuthula Luthuli ◽  
Ovokeroye A. Abafe ◽  
Leshweni J. Shai ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Hair Analysis ◽  
Historical Record ◽  
Body Fluids ◽  
Urine Samples ◽  
Long Term Effects ◽  
Experimental Animals ◽  
Explorative Study ◽  
Hair Samples

Analysis of body fluids and tissues of aflatoxin exposed individuals for the presence of aflatoxins and aflatoxin metabolites has emerged as a reliable indicator of exposure and metabolism of aflatoxins. However, current aflatoxin biomarkers are not appropriate for investigating the long-term effects of aflatoxin exposure. In this explorative study, we investigated the analysis of hair as a complementary or alternative matrix for the assessment of biomarkers of long-term aflatoxin exposure. Three groups of guinea pigs were orally dosed with 5 ugkg−1bw−1, 50 ugkg−1bw−1, and 100 ugkg−1bw−1 of AFB1. Urine and hair samples were collected on days 0, 1, 2, 3, 7, 30, 60, and 90 and analysed for AFB1 and AFM1 using UHPLC-MS/MS. AFB1 and AFM1 were detected in 75% and 13.6%, respectively, of the day 1 to day 7 urine samples. AFB1 was detected in hair samples collected from day 3 up to day 60. This is the first report to confirm the deposition of AFB1 in the hair of experimental animals. These findings indicate that hair analysis has the potential to provide an accurate long-term historical record of aflatoxin exposure with potentially important implications for the field of aflatoxin biomarkers.

scholarly journals Long-Term Effects of Early-Life Exposure to Environmental Oestrogens on Ovarian Function: Role of Epigenetics

2014 ◽  
Vol 26 (9) ◽  
pp. 613-624 ◽  
Author(s):  
G. Cruz ◽  
W. Foster ◽  
A. Paredes ◽  
K. D. Yi ◽  
M. Uzumcu
Keyword(s):  
Early Life ◽  
Ovarian Function ◽  
Long Term Effects ◽  
Early Life Exposure

Does the Age That Children Start Kindergarten Matter? Evidence of Long-Term Educational and Social Outcomes

2006 ◽  
Vol 28 (2) ◽  
pp. 153-179 ◽  
Author(s):  
Jane Arnold Lincove ◽  
Gary Painter
Keyword(s):  
Social Outcomes ◽  
School Entry ◽  
Academic Standards ◽  
Long Term Effects ◽  
National Education ◽  
Early Elementary School ◽  
Transition From High School ◽  
The Impact ◽  
Effect Of Age

The appropriate age for students to begin school is an issue of debate for educators, administrators, and parents. Parents worry that young children may not be able to compete with older classmates; schools worry that young students will not be able to meet rigorous academic standards associated with school accountability. Past literature is inconclusive as to the overall effect of age at school entry. Some research suggests that younger students have lower average achievement in early elementary school, while others find that students with summer birthdates, who are assumed to be younger at school entry, gain more education on average. At present, little is known about the impact of age at school entry on education attainment as students transition from high school into college and the labor market. This study uses data from the National Education Longitudinal Survey to examine long-term effects of age at school entry on both educational and social outcomes, with special attention to those students who enter kindergarten a year later than their peers. The results of this study suggest that delaying kindergarten does not create any long-term advantages for students.

3 to 5 Years Later: Long-term Effects of Prophylactic Bilateral Salpingectomy on Ovarian Function

2017 ◽  
Vol 24 (1) ◽  
pp. 145-150 ◽  
Author(s):  
Roberta Venturella ◽  
Daniela Lico ◽  
Massimo Borelli ◽  
Maria G. Imbrogno ◽  
Gabriele Cevenini ◽  
...  
Keyword(s):  
Ovarian Function ◽  
Long Term Effects ◽  
Bilateral Salpingectomy

scholarly journals Long-term effects of porcine zonae pellucidae immunocontraception on ovarian function in feral horses (Equus caballus)

Reproduction ◽  
1992 ◽  
Vol 94 (2) ◽  
pp. 437-444 ◽  
Author(s):  
J. F. Kirkpatrick ◽  
I. M. K. Liu ◽  
J. W. Turner ◽  
R. Naugle ◽  
R. Keiper
Keyword(s):  
Ovarian Function ◽  
Equus Caballus ◽  
Long Term Effects ◽  
Feral Horses

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

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