The behavior of reinforced concrete (RC) and reinforced engineered cementitious composites (ECC) was comparatively investigated at the component and system levels through a small-scale (1/8 scale factor) experimental program. The logistical and financial advantages of small-scale testing were utilized to investigate a range of parameters, including the effect of reinforcement ratio and material properties, on the response of reinforced concrete and reinforced ECC structures. The procedures pertaining to material preparation, specimen construction, and input motion development that were critical for enhancing the similarity between the scales are provided. Engineered cementitious composite mixtures with different cost and sustainability indices were evaluated. Under cyclic loading, the stiffness, strength, ductility, and energy absorption capacity of columns made of different ECC mixtures were found to be 110, 65, 45, and 100% higher, respectively, than those of the RC columns. The system level investigation through hybrid simulation showed that the ECC structures sustain less deformation under earthquake excitation due to high energy absorption capacity of the material. The differences in cost, sustainability, and structural performance of different ECC mixtures suggest that a careful selection of materials is required for optimal performance.