scholarly journals Expansion of Highly Differentiated Cytotoxic Terminally Differentiated Effector Memory CD8+ T Cells in a Subset of Clinically Stable Kidney Transplant Recipients: A Potential Marker for Late Graft Dysfunction

2014 ◽  
Vol 25 (8) ◽  
pp. 1856-1868 ◽  
Author(s):  
Michelle Yap ◽  
Françoise Boeffard ◽  
Emmanuel Clave ◽  
Annaick Pallier ◽  
Richard Danger ◽  
...  
Keyword(s):  
T Cells ◽  
Kidney Transplant ◽  
Cd8 T Cells ◽  
Effector Memory ◽  
Transplant Recipients ◽  
Graft Dysfunction ◽  
Kidney Transplant Recipients ◽  
Memory Cd8 T Cells ◽  
Potential Marker

TEMRA CD8 T Cells from Human Kidney Transplant Recipients Exhibit Potent Anti-Donor Reactivity and Induce GVHD in Humanized Mouse Model

2018 ◽  
Vol 102 ◽  
pp. S49 ◽  
Author(s):  
Lola Jacquemont ◽  
Gaelle Tilly ◽  
Virginie Huchet ◽  
Pierrick Guerif ◽  
Magali Giral ◽  
...  
Keyword(s):  
T Cells ◽  
Mouse Model ◽  
Kidney Transplant ◽  
Cd8 T Cells ◽  
Human Kidney ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Humanized Mouse ◽  
Humanized Mouse Model

Detection of CD8+ T Cells Sensitized to BK Virus Large T Antigen in Healthy Volunteers and Kidney Transplant Recipients

2006 ◽  
Vol 67 (4-5) ◽  
pp. 298-302 ◽  
Author(s):  
Parmjeet S. Randhawa ◽  
Iulia Popescu ◽  
Camila Macedo ◽  
Adriana Zeevi ◽  
Ron Shapiro ◽  
...  
Keyword(s):  
T Cells ◽  
Healthy Volunteers ◽  
Kidney Transplant ◽  
Cd8 T Cells ◽  
T Antigen ◽  
Bk Virus ◽  
Large T Antigen ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Rejection quantity in kidney transplant recipients is associated with increasing intracellular interleukin-2 in CD8+ T-cells

2014 ◽  
Vol 31 (1) ◽  
pp. 17-21 ◽  
Author(s):  
Bora Akoglu ◽  
Barbara Lafferton ◽  
Shara Kalb ◽  
Said Emal Yosuf ◽  
Eva Herrmann ◽  
...  
Keyword(s):  
T Cells ◽  
Kidney Transplant ◽  
Cd8 T Cells ◽  
Interleukin 2 ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Virus-Specific CD8+T Cells Cross-Reactive to Donor-Alloantigen Are Transiently Present in the Circulation of Kidney Transplant Recipients Infected With CMV and/or EBV

2016 ◽  
Vol 16 (5) ◽  
pp. 1480-1491 ◽  
Author(s):  
K. M. Heutinck ◽  
S. L. Yong ◽  
L. Tonneijck ◽  
H. van den Heuvel ◽  
N. C. van der Weerd ◽  
...  
Keyword(s):  
T Cells ◽  
Kidney Transplant ◽  
Cd8 T Cells ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Systemic varicella zoster virus reactive effector memory T-cells impaired in the elderly and in kidney transplant recipients

2012 ◽  
Vol 84 (12) ◽  
pp. 2018-2025 ◽  
Author(s):  
Nicole M. van Besouw ◽  
Georges M.G.M. Verjans ◽  
Joke M. Zuijderwijk ◽  
Nicolle H.R. Litjens ◽  
Albert D.M.E. Osterhaus ◽  
...  
Keyword(s):  
T Cells ◽  
Varicella Zoster Virus ◽  
Kidney Transplant ◽  
Memory T Cells ◽  
The Elderly ◽  
Effector Memory ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Varicella Zoster ◽  
Effector Memory T Cells

scholarly journals Homeostatic Repopulation by CD28−CD8+ T Cells in Alemtuzumab-Depleted Kidney Transplant Recipients Treated With Reduced Immunosuppression

2008 ◽  
Vol 8 (2) ◽  
pp. 338-347 ◽  
Author(s):  
P. Trzonkowski ◽  
M. Zilvetti ◽  
S. Chapman ◽  
J. Więckiewicz ◽  
A. Sutherland ◽  
...  
Keyword(s):  
T Cells ◽  
Kidney Transplant ◽  
Cd8 T Cells ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Terminally Differentiated Effector Memory CD8+ T Cells Identify Kidney Transplant Recipients at High Risk of Graft Failure

2020 ◽  
Vol 31 (4) ◽  
pp. 876-891
Author(s):  
Lola Jacquemont ◽  
Gaëlle Tilly ◽  
Michelle Yap ◽  
Tra-My Doan-Ngoc ◽  
Richard Danger ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Kidney Transplant ◽  
Graft Failure ◽  
T Cell Subsets ◽  
Effector Memory ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Post Transplant ◽  
Transplant Failure

BackgroundIdentifying biomarkers to predict kidney transplant failure and to define new therapeutic targets requires more comprehensive understanding of the immune response to chronic allogeneic stimulation.MethodsWe investigated the frequency and function of CD8+ T cell subsets—including effector memory (EM) and terminally differentiated EM (TEMRA) CD8+ T cells—in blood samples from 284 kidney transplant recipients recruited 1 year post-transplant and followed for a median of 8.3 years. We also analyzed CD8+ T cell reactivity to donor-specific PBMCs in 24 patients who had received living-donor kidney transplants.ResultsIncreased frequency of circulating TEMRA CD8+ T cells at 1 year post-transplant associated with increased risk of graft failure during follow-up. This association remained after adjustment for a previously reported composite of eight clinical variables, the Kidney Transplant Failure Score. In contrast, increased frequency of EM CD8+ T cells associated with reduced risk of graft failure. A distinct TEMRA CD8+ T cell subpopulation was identified that was characterized by expression of FcγRIIIA (CD16) and by high levels of proinflammatory cytokine secretion and cytotoxic activity. Although donor-specific stimulation induced a similar rapid, early response in EM and TEMRA CD8+ T cells, CD16 engagement resulted in selective activation of TEMRA CD8+ T cells, which mediated antibody-dependent cytotoxicity.ConclusionsAt 1 year post-transplant, the composition of memory CD8+ T cell subsets in blood improved prediction of 8-year kidney transplant failure compared with a clinical-variables score alone. A subpopulation of TEMRA CD8+ T cells displays a novel dual mechanism of activation mediated by engagement of the T-cell receptor or of CD16. These findings suggest that TEMRA CD8+ T cells play a pivotal role in humoral and cellular rejection and reveal the potential value of memory CD8+ T cell monitoring for predicting risk of kidney transplant failure.

scholarly journals Clinical significance of CCR7+CD8+ T cells in kidney transplant recipients with allograft rejection

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Kyoung Woon Kim ◽  
Bo-Mi Kim ◽  
Kyoung Chan Doh ◽  
Mi-La Cho ◽  
Chul Woo Yang ◽  
...  
Keyword(s):  
T Cells ◽  
Kidney Transplant ◽  
Clinical Significance ◽  
Cd8 T Cells ◽  
Allograft Rejection ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients
Sign in / Sign up

Export Citation Format

Share Document