Computational engineering of surface layer ground Al2O3‒TiC ceramic. Thermal analysis

Author(s):  
V. V. Kuzin ◽  
S. N. Grigoriev ◽  
M. A. Volosova

The regularities of the thermal and stress state of the surface layer of ground Al2O3‒TiC ceramic under influence of heat flow are established. It is revealed that the role of the thermal factor in the fracture mechanism of this layer is manifested in the formation of unfavorable microstructural stress concentrators.

Author(s):  
V. V. Kuzin ◽  
S. N. Grigor’ev ◽  
M. A. Volosova

The main regularities of the stress state of the surface layer of ground Al2O3‒TiC ceramic under the combined load are determined. It is revealed that the force load compensates for thermal elastic deformations, but at the same time complicates the stress state in comparison with the action of loads of the same type. The role of the combination of structural elements that formed the surface of Al2O3‒TiC ceramic in the formation of unfavorable microstructural stress concentrators is established.


2021 ◽  
Vol 1 (7) ◽  
pp. 57-62
Author(s):  
V. V. Kuzin ◽  
M. A. Volosova ◽  
M. Yu. Fedorov

The regularities of influence of AlN and TiN coatings on stress-strain state of Al2O3‒TiC ceramics structural elements, which forming its surface layer, under influence of heat flow are established. The formation of microstructural stress concentrators at the boundary of AlN and TiN coatings with the initial ceramics is revealed.


1970 ◽  
Author(s):  
A. E. Wechsler ◽  
E. M. Drake ◽  
F. E. Ruccia ◽  
J. E. McCullough ◽  
P. Felsenthal ◽  
...  

Author(s):  
В. Бутенко ◽  
V. Butenko

The assessment indices of surface layer effective state in machinery subjected to different ways of finishing are considered. The role of the dislocation restructurization process in the formation of operation characteristics of surface layer material quality and prediction of its working capacity is shown. A generalized quality index of multi-component functional layers formed on operation surfaces of machinery is described.


2021 ◽  
pp. 103513
Author(s):  
Dmitrii A. Kremenchutskii ◽  
Gennady F. Batrakov ◽  
Illarion I. Dovhyi ◽  
Yury A. Sapozhnikov

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Amir Ata Saei ◽  
Christian M. Beusch ◽  
Pierre Sabatier ◽  
Juan Astorga Wells ◽  
Hassan Gharibi ◽  
...  

AbstractDespite the immense importance of enzyme–substrate reactions, there is a lack of general and unbiased tools for identifying and prioritizing substrate proteins that are modified by the enzyme on the structural level. Here we describe a high-throughput unbiased proteomics method called System-wide Identification and prioritization of Enzyme Substrates by Thermal Analysis (SIESTA). The approach assumes that the enzymatic post-translational modification of substrate proteins is likely to change their thermal stability. In our proof-of-concept studies, SIESTA successfully identifies several known and novel substrate candidates for selenoprotein thioredoxin reductase 1, protein kinase B (AKT1) and poly-(ADP-ribose) polymerase-10 systems. Wider application of SIESTA can enhance our understanding of the role of enzymes in homeostasis and disease, opening opportunities to investigate the effect of post-translational modifications on signal transduction and facilitate drug discovery.


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