scholarly journals Conditions of "General Significance" of Knowledge in Formal Pragmatics

2019 ◽  
pp. 35-42
Author(s):  
Aleksandr S. Gaponov ◽  
◽  
Keyword(s):  
General Significance

scholarly journals Gene Conversion Alone Accounts for More Than 90% of Recombination Events at the am Locus of Neurospora crassa

Genetics ◽  
1996 ◽  
Vol 143 (1) ◽  
pp. 129-136 ◽  
Author(s):  
Frederick J Bowring ◽  
David E A Catcheside
Keyword(s):  
Molecular Markers ◽  
Neurospora Crassa ◽  
Gene Conversion ◽  
Holliday Junctions ◽  
Crossing Over ◽  
Gene Markers ◽  
General Significance ◽  
Flanking Sequences ◽  
Simple Conversion

Abstract We have used closely flanking molecular markers located ~4 kb distal and 6 kb proximal of the am locus to investigate the incidence of crossover events associated with the generation of prototrophic recombinants in a cross heteroallelic am1 am6. Ninety-three percent of prototrophs were generated by events that did not recombine the molecular markers, indicating that simple conversion accounts for the formation of most prototrophs and that associated crossovers are much less frequent (~0.07) than estimated previously using more distant flanking markers. This suggests that conversion and crossing over during meiosis may arise from distinct mechanisms or that if, as is widely supposed, conversion and crossing over result from alternate modes of resolution of Holliday junctions then, at least for the am locus of Neurospora, the mode of resolution is strongly biased in favor of retaining the parental association of flanking sequences. Because estimates of the association of conversion and crossing over based on more distant gene markers are similar for yeast and Neurospora (~0.35), our observation may have general significance.

Cupid, Apollo, and Daphne (Ovid, Met. 1. 452 ff.)

1980 ◽  
Vol 30 (1) ◽  
pp. 174-182 ◽  
Author(s):  
W. S. M. Nicoll
Keyword(s):  
General Significance

The general significance of Ovid's Apollo-Dapbne (Met. 1. 452 ff.) within its immediate context seems plain enough. Ovid's technique, as Otis remarks, is to set epic pretensions beside elegiac behaviour and thus to show a struggle between incompatible styles of life and poetry. Yet the episode still poses certain problems. These mainly concern the significance of the story within the wider context of the opening of Ovid's poem. One difficulty is hinted at by Otis himself. He observes that with the Apollo-Dapbne and Jupiter-10 (1. 568 ff.) Ovid has ‘deflated his divine prologue’. Yet elsewhere3 Otis remarks that in one sense the gap between the behaviour of the gods in the concilium deorum (1. 163 ff.) and their philandering in the Daphne and Io stories is very slight.

Selection in operant learning may fit a general model

2001 ◽  
Vol 24 (3) ◽  
pp. 542-543
Author(s):  
Julian C. Leslie
Keyword(s):  
Natural Selection ◽  
General Model ◽  
Operant Response ◽  
Operant Learning ◽  
General Significance

The generic account of selection proposed by Hull et al. readily fits operant learning where, by comparison with natural selection, the process is well understood but little is known about the mechanism. Objections within psychology, that operant learning ignores internal processes, fail to recognise the general significance of behaviour-environment interactions. Variation within operant response classes requires further investigation.

Inactivation of Insulin by the Isolated Liver of the Bullfrog

1956 ◽  
Vol 188 (1) ◽  
pp. 45-48 ◽  
Author(s):  
Shirley Weisenfeld ◽  
Raul Hernandez Jauregui ◽  
Martin G. Goldner
Keyword(s):  
Liver Tissue ◽  
Liver Perfusion ◽  
Hypoglycemic Activity ◽  
Slow Inactivation ◽  
General Significance ◽  
Liver Slices ◽  
Isolated Liver

Experiments are presented in which insulin solutions were perfused through isolated frog livers in order to study the inactivation of this hormone by liver tissue. The solutions were recirculated many times and aliquots were tested biologically at various intervals for hypoglycemic activity. While insulin retains its activity after a single frog liver perfusion, it is gradually inactivated with increasing numbers of reperfusions. This result is in accord with the inactivation of insulin by liver slices and liver brei as reported by others. The relatively slow inactivation of insulin when perfused through the isolated frog liver is in contrast to the inactivation of glucagon which, as previously reported, loses its hyperglycemic activity after a single perfusion through this preparation. The general significance of this finding is discussed.

Beyond the Great Divide: globalization and the theory of international relations

1998 ◽  
Vol 24 (4) ◽  
pp. 479-498 ◽  
Author(s):  
IAN CLARK
Keyword(s):  
International Relations ◽  
Analytical Model ◽  
External Environment ◽  
International Relations Theory ◽  
The State ◽  
Middle Ground ◽  
State Action ◽  
Theoretical Scheme ◽  
General Significance ◽  
External Forces

This article assesses the general significance for International Relations theory of the literature on globalization. It argues that globalization is a pervasively unsettling process which needs to be explained not only as an issue in its own right but for the insight which it affords into cognate areas of theory. In short, it advances an analytical model whereby globalization itself can be understood and utilizes this as a theoretical scheme that may be applied more generally. The predominant conceptualization of the globalization issue within International Relations has been the debate between the proponents of state redundancy and the champions of continuing state potency. In turn, these arguments rest upon an image of state capacities being eroded by external forces, or alternatively of external forces being generated by state action. In either case, there is the assumed duality of the state(s) set off from, and ranged against, a seemingly external environment. Instead, this article argues that the state occupies a middle ground between the internal and external and is itself both shaped by and formative of the process of globalization.

Dante's Paradiso: Cantos XXIV-XXVI

PMLA ◽  
1889 ◽  
Vol 4 (1) ◽  
pp. 24-40
Author(s):  
Edward L. Walter
Keyword(s):  
Vast Number ◽  
Literal Sense ◽  
General Significance ◽  
Divina Commedia

The xxivth, xxvth and xxvith books of the ‘Paradiso’ consist chiefly of what has always been something of a puzzle to me, the examination of Dante by Peter, James and John, on Faith, Hope and Love. The allegory of the ‘Divina Commedia,’ clear enough in its main outlines, becomes matter for endless discussion as soon as we descend into details, but nowhere else, so far as I have observed, is there any difficulty in interpreting the general significance of so large a body of verse as these three books, if we take the literal sense, or in adapting it to some one theory, if we take the allegorical sense. The fact that I do not find any discussion of this puzzling examination in the Dante literature accessible to me has made me somewhat fearful of committing an offense very common in the study of all masterpieces in all literatures; but I console myself by the reflection, that in the vast number of Dante students who have found difficulties where none existed, I should feel myself in good company.

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