scholarly journals Asymptomatic Intestinal Spirochetosis Found Incidentally in Endoscopic Specimens

2021 ◽  
Vol 12 (1) ◽  
pp. 29-34
Author(s):  
Yasushi Ariizumi ◽  
Masatomo Doi ◽  
Motohiro Chosokabe
Keyword(s):  
Intestinal Spirochetosis

scholarly journals 716. A Case of Symptomatic Intestinal Spirochetosis

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S409-S409
Author(s):  
Zhi En Chan ◽  
Jasmine Chung Shimin
Keyword(s):  
Venereal Disease ◽  
Lower Abdominal Pain ◽  
Colonic Polyps ◽  
Local Context ◽  
Brachyspira Pilosicoli ◽  
16S Rna ◽  
Intestinal Spirochetosis ◽  
Mucous Discharge ◽  
Treatable Condition ◽  
Brachyspira Aalborgi

Abstract Background Intestinal spirochetosis (IS) is a condition caused by Brachyspira aalborgi and Brachyspira Pilosicoli. Its clinical significance has long been a point of contention with some debating that these spirochetes are simply colonic commensals. It is a condition that is more prevalent in developing nations as well as patients with HIV and the homosexual population. The epidemiology and prevalence of IS has not been studied in the local context. Methods We reviewed a case of a 37-year-old man who presented with a two month history of persistent lower abdominal pain, hematochezia, and increase in mucous discharge per rectum. He is sexually active with multiple male partners, and was previously treated for gonorrhea, chlamydia, and syphilis. His basic laboratory investigations were unremarkable, Venereal Disease Research Laboratory (VDRL) antibody and human immunodeficiency virus (HIV) screen were both non-reactive. Computed tomography of the abdomen was unremarkable. Endoscopic evaluation revealed multiple discrete ulcers measuring 1-2mm seen only in the rectum. Random biopsies of the cecum, ascending colon, transverse colon and descending colon showed mild acute colitis with IS. There was also mild to moderate acute proctitis in the rectum with spirochetes seen. 16s RNA gene sequencing of the biopsy specimen were confirmatory for Brachyspira aalborgi. Investigation findings. A: Discrete Ulcers found in rectum, B: Hemotoxylin and Eosin stained specimen showing proctitis, C: False brush Border appearance D: Spirochetes on Warthin Starry stain Results The patient received a 10 day course of metronidazole with complete resolution of his symptoms. Conclusion This case demonstrates the existence of a treatable condition that can be diagnosed with current available investigations for patients with similar symptoms. Recognising at risk populations can also raise clinical suspicion for this condition. Some studies have found associations between IS with development of colonic polyps and also certain colorectal cancers. Further studies on this treatable condition and its disease burden in the local context should be further explored. Disclosures All Authors: No reported disclosures

Intestinal spirochetosis and chronic watery diarrhea: Clinical and histological response to treatment and long-term follow up

2006 ◽  
Vol 21 (8) ◽  
pp. 1326-1333 ◽  
Author(s):  
Maria Esteve ◽  
Antonio Salas ◽  
Fernando Fernandez-Banares ◽  
Josep Lloreta ◽  
Meritxell Marine ◽  
...  
Keyword(s):  
Response To Treatment ◽  
Watery Diarrhea ◽  
Histological Response ◽  
Intestinal Spirochetosis ◽  
Long Term Follow Up

scholarly journals Human intestinal spirochetosis in Japan; its incidence, clinicopathologic features, and genotypic identification

2007 ◽  
Vol 21 (2) ◽  
pp. 76-84 ◽  
Author(s):  
Jin Tanahashi ◽  
Tsutomu Daa ◽  
Ayako Gamachi ◽  
Kenji Kashima ◽  
Yoshiyuki Kondoh ◽  
...  
Keyword(s):  
Clinicopathologic Features ◽  
Intestinal Spirochetosis ◽  
Human Intestinal Spirochetosis ◽  
Genotypic Identification

High Prevalence of Abnormal Colonoscopical Findings in Human Intestinal Spirochetosis

2009 ◽  
Vol 69 (5) ◽  
pp. AB299
Author(s):  
Masaaki Higashiyama ◽  
Sho Ogata ◽  
Yoshikazu Adachi ◽  
Junichiro Nishiyama ◽  
Koji Matsuzaki ◽  
...  
Keyword(s):  
Intestinal Spirochetosis ◽  
High Prevalence ◽  
Human Intestinal Spirochetosis

scholarly journals Clinical significance of human intestinal spirochetosis

2020 ◽  
Vol 96 (1) ◽  
pp. 72-74
Author(s):  
Naoki Ogiwara ◽  
Chie Inomoto ◽  
Masashi Yokota ◽  
Erika Teramura ◽  
Yoshitaka Arase ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Intestinal Spirochetosis ◽  
Human Intestinal Spirochetosis

Intestinal Spirochetosis

2005 ◽  
Vol 29 (7) ◽  
pp. 982 ◽  
Author(s):  
Edward R Uhlemann ◽  
Cecilia Fenoglio-Preiser
Keyword(s):  
Intestinal Spirochetosis

Human intestinal spirochetosis diagnosed with colonoscopy and analysis of partial 16S rDNA sequences of involved spirochetes

2001 ◽  
Vol 2 (1) ◽  
pp. 111-116 ◽  
Author(s):  
Wolfgang Kraatz ◽  
Ulf Thunberg ◽  
Bertil Pettersson ◽  
Claes Fellström
Keyword(s):  
16S Rdna ◽  
Type Strain ◽  
Sequence Similarity ◽  
Rdna Sequences ◽  
Intestinal Spirochetosis ◽  
16S Rdna Sequences ◽  
Pcr Products ◽  
Human Intestinal Spirochetosis ◽  
Type Strains ◽  
Rrna Sequences

AbstractDNA was extracted from colonic biopsies of 33 patients with and three without evidence of intestinal spirochetosis (IS) in the large bowel. The biopsies were subjected to PCR. A pair of primers, generating a 207 bp fragment, were designed to detect specifically the 16S rDNA gene ofBrachyspira. PCR products of the expected size were obtained from 33 samples with histologic evidence of IS. The PCR amplicons were used for sequencing. The sequences obtained were aligned to the corresponding 16S rRNA sequences of five type strains ofBrachyspira. The sequences of 23 PCR products were 99–100% identical with the correspond-ingB.aalborgitype strain sequence. Two cases showed 99–100% sequence similarity with the type strain ofB.pilosicoliP43/6/78. Six cases could not be referred to any of the known species ofBrachyspira. Two PCR products gave incomplete sequences.

scholarly journals An Unusual Case of Subacute Appendicitis and Intestinal Spirochetosis

Cureus ◽  
2021 ◽  
Author(s):  
Eman Chaudhri ◽  
Abdul Hakim Almakadma ◽  
Sami Almustanyir ◽  
Abdulaziz Taleb ◽  
Nawaf Alotaibi
Keyword(s):  
Unusual Case ◽  
Intestinal Spirochetosis
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