scholarly journals Human embryonic gonad dissociation with Collagenase IV v1 (protocols.io.btjznkp6)

protocols.io ◽  
2021 ◽  
Author(s):  
Carmen Sancho ◽  
Regina Hoo ◽  
Roser Vento-Tormo
Keyword(s):  
Embryonic Gonad ◽  
Collagenase Iv

scholarly journals Choriocarcinoma metastatic to the skin: A rare occurrence associated with dismal outcome

Rare Tumors ◽  
2021 ◽  
Vol 13 ◽  
pp. 203636132110397
Author(s):  
Mousa ElKhaldi ◽  
Rakan Radi ◽  
Maysa Al-Hussaini
Keyword(s):  
Back Pain ◽  
Germ Cell ◽  
Lower Back Pain ◽  
Germ Cell Tumors ◽  
Cutaneous Metastasis ◽  
Hematogenous Metastasis ◽  
Rare Occurrence ◽  
Lower Back ◽  
Embryonic Gonad ◽  
Work Up

Germ cell tumors (GCTs) are a histologically heterogeneous group of tumors that arise from the primitive germ cell of the embryonic gonad. Choriocarcinoma is a variant of GCTs that is prone to hematogenous metastasis to the liver, lung, and brain. Cutaneous metastasis in choriocarcinoma is rarely encountered with only a few cases reported in literature. We report the case of a 28-year-old male presenting with lower back pain that, upon further work-up, was diagnosed with pure choriocarcinoma of the testes. Around 9 months after his initial presentation, he developed a cutaneous back lesion. Microscopic examination confirmed the presence of choriocarcinoma composed of mononuclear cytotrophoblasts which interweave with multinucleated syncytiotrophoblasts. The patient passed away 3 weeks after the onset of cutaneous metastasis.

Role of mammalian Y chromosome in sex determination

1988 ◽  
Vol 322 (1208) ◽  
pp. 63-72 ◽  
Keyword(s):  
Cell Differentiation ◽  
Sex Determination ◽  
Y Chromosome ◽  
Sertoli Cell ◽  
Sertoli Cells ◽  
Sex Reversal ◽  
Testicular Development ◽  
Chimeric Mouse ◽  
Embryonic Gonad

It has long been assumed that the mammalian Y chromosome either encodes, or controls the production of, a diffusible testis-determining molecule, exposure of the embryonic gonad to this molecule being all that is required to divert it along the testicular pathway. My recent finding that Sertoli cells in XX ↔ XY chimeric mouse testes are exclusively XY has led me to propose a new model in which the Y acts cell-autonomously to bring about Sertoli-cell differentiation. I have suggested that all other aspects of foetal testicular development are triggered by the Sertoli cells without further Y-chromosome involvement. This model thus equates mammalian sex determination with Sertoli-cell determination. Examples of natural and experimentally induced sex reversal are discussed in the context of this model.

scholarly journals Role of autonomous and non-autonomous sex determination signals in sexually dimorphic development of the Drosophila embryonic gonad

2007 ◽  
Vol 306 (1) ◽  
pp. 313 ◽  
Author(s):  
N.R. Crnkovich ◽  
T.J. DeFalco ◽  
S Le Bras ◽  
A.L. Casper ◽  
M.B. Van Doren
Keyword(s):  
Sex Determination ◽  
Sexually Dimorphic ◽  
Embryonic Gonad

scholarly journals The Rhox Homeobox Gene Family Shows Sexually Dimorphic and Dynamic Expression During Mouse Embryonic Gonad Development1

2008 ◽  
Vol 79 (3) ◽  
pp. 468-474 ◽  
Author(s):  
Hinda Daggag ◽  
Terje Svingen ◽  
Patrick S. Western ◽  
Jocelyn A. van den Bergen ◽  
Peter J. McClive ◽  
...  
Keyword(s):  
Gene Family ◽  
Homeobox Gene ◽  
Sexually Dimorphic ◽  
Embryonic Gonad ◽  
Dynamic Expression

scholarly journals Proteolytic Activity During the Growth of C6 Astrocytoma in the Murine Spheroid Implantation Model

1992 ◽  
Vol 19 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Indrasen S. Vaithilingam ◽  
Warren McDonald ◽  
Eric C. Stroude ◽  
Robert A. Cook ◽  
Rolando F. Del Maestro
Keyword(s):  
Proteolytic Activity ◽  
Tumor Tissue ◽  
Maximal Activity ◽  
Vascular Basement Membrane ◽  
Astrocytoma Cells ◽  
Maximum Value ◽  
C6 Astrocytoma ◽  
Cerebral Cortex Tissue ◽  
Collagenase Iv ◽  
Implantation Model

ABSTRACT:General protease and collagenase IV activity are involved in the remodelling of the vascular basement membrane that occurs during tumor-induced angiogenesis. This study has assessed the level of these enzymes in tumor, peritumoral or contralateral cerebral cortex tissue during the growth of C6 astrocytoma in the rat spheroid implantation model. General proteolytic activity was increased in tumor tissue beginning on day 8 following spheroid implantation, then increased to a maximum value on day 11 and decreased to control values on day 18. A similar pattern was seen for collagenase IV activity but maximal activity occurred on day 13. The peritumor and tumor patterns of activity were similar. General protease activity was increased in the hemisphere contralateral to the tumor suggesting that the growth of C6 astrocytoma in rat brain was influencing biochemical events distant from the tumor. C6 astrocytoma cells orchestrate a cascade of proteolytic events which may play a crucial role in angiogenesis associated with tumor growth in the model system studied.

scholarly journals Flow Regulation of 72-kD Collagenase IV (MMP-2) After Experimental Arterial Injury

Circulation ◽  
1998 ◽  
Vol 98 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Hisham S. Bassiouny ◽  
Ruo H. Song ◽  
Xue F. Hong ◽  
Ashok Singh ◽  
Hrachya Kocharyan ◽  
...  
Keyword(s):  
Arterial Injury ◽  
Flow Regulation ◽  
Collagenase Iv
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