scholarly journals Relation of elevated serum adenosine deaminase levels to glycated hemoglobin and serum uric acid in type 2 diabetes mellitus

2016 ◽  
Vol 4 (7) ◽  
pp. 1148-1154
Author(s):  
Dr Debes Ray ◽  
◽  
Dr Dipankar Kundu ◽  
Dr Debkanya Gon Chowdhury ◽  
Dr Srinika Ghosh ◽  
...  
2013 ◽  
Vol 112 (4) ◽  
pp. 499-504 ◽  
Author(s):  
Filippo Valbusa ◽  
Lorenzo Bertolini ◽  
Stefano Bonapace ◽  
Luciano Zenari ◽  
Giacomo Zoppini ◽  
...  

2016 ◽  
Vol 1 (1) ◽  
pp. 13
Author(s):  
Shashikala Magadi Dasegowda ◽  
Ashok Kumar Jeppu ◽  
Sushith ◽  
Kavitha Ashok Kumar

<strong>Aim</strong>: Study was conducted to compare and correlate the levels of serum adenosine deaminase and serum uric acid with Fasting Plasmaglucose (FPG), Post Prandial Blood Sugar (PPBS) and glycated hemoglobin in type 2 diabetes mellitus. <strong>Materials and Method</strong>: Study group consisted of 60 diabetics and 50 age and sex matched healthy individuals. Blood sample was collected in fasting state and two hours after the food for estimation of serum Adenosine Deaminase (ADA), uric acid, parameters of lipid profile, fasting and postprandial glucose. <strong>Result</strong>: An increased level of serum ADA, FPG, PPBS, parameters of lipid profile and glycated haemoglobin in type 2 diabetes mellitus compared to controls. A statistically significant correlation was seen between serum ADA as well as serum uric acid with, Fasting Plasma Glucose (FPG), Post Prandial Blood Glucose (PPBS), glycated haemoglobin. Serum ADA had shown significant correlation with the Triglyceride (TG), Total Cholesterol (TC), Low Density Cholesterol (LDL cholesterol). A negative correlation was seen between serum ADA acid and High Density Lipoprotein cholesterol (HDL cholesterol). <strong>Conclusion</strong>: Adenosine deaminase and serum uric acid levels increased and positively correlated with parameters of lipid profile and glycemic control. This indicates that ADA and serum uric acid can serve as predictor of glycaemic index and help to monitor the long term effects of diabetes mellitus.


2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62


2018 ◽  
Vol 1 (4) ◽  
pp. 134-138 ◽  
Author(s):  
Burcin Meryem Atak ◽  
Tuba Taslamacioglu Duman ◽  
Mehmet Zahid Kocak ◽  
Haluk Savli

Author(s):  
Amarensi Milka Betaubun ◽  
Fitriani Mangarengi ◽  
Ruland DN Pakasi

Diabetes Mellitus (DM) belongs to the group of metabolic diseases. The long-term complications of diabetes such as: diabeticretinopathy, neuropathy, and nephropathy, can be prevented or reduced by controlling the blood glucose levels. Impaired glucose tolerance,hypertension and dyslipidemia can decrease the disappearance from proximal tubules resulting in an increase in serum uric acid. The aimof the study to know the ratio of uric acid urine/serum in DMT2 with controls. This research study used a cross sectional study was andconducted on 35 samples of type 2 diabetes mellitus and 35 control samples of In- and Out-patient Clinics at the Dr. Wahidin SudirohusodoHospital, Makassar. The blood glucose, uric acid levels and urine uric acid were examined by ABX Pentra 400 (colorimetric method). Thenumber of DMT2 male patients was higher than females. Most of their age were between 50−54 years. The ratio of the urinary levels ofurine/serum UA was positively correlated to: age, sex, urine UA in DMT2 and control. Their data were analyzed with unpaired t test (p =0.00). This research showed that the ratio of urine/serum UA in DMT2 was 1.5 times than the controls. The results of this study showedan increase in the ratio of urinary levels of serum uric acid as 1.5 times higher than the controls.


2021 ◽  
pp. 20-22
Author(s):  
Shajahan Shajahan ◽  
Koneru Sri Lahari ◽  
P. Kiranmai

BACKGROUND:Type 2 Diabetes Mellitus is a major non-communicable disease resulting from insulin resistance and is associated with cardiovascular,neurological and renal complications.Recent studies show association of hyperuricemia and Diabetes Mellitus.Uric acid increases oxidative stress that leads to vascular dysfunction and high intra glomerular pressure leading to renal complications.High serum creatinine is an indicator of renal compromise. OBJECTIVES: To evaluate serum uric acid and serum creatinine levels in type 2 diabetes mellitus patients and to find association between them. METHODOLOGY: The study was conducted in Osmania general hospital. Fifty cases of established Type 2 Diabetes Mellitus formed the study group and 50 normal healthy individuals formed the control group. Serum uric acid, Fasting Blood Glucose (FBS) and serum creatinine were estimated by colorimetric enzymatic methods on Beckman coulter AU5800.Mean values were compared in cases and controls using student t- test.Study group was further studied under 2 subgroups with serum Uric acid < 7 mg/dl and ≥7 mg/dl.In these 2 subgroups the association of Serum uric acid with FBS and creatinine was analysed statistically. RESULTS: Serum uric acid were found high in cases(7.63+/- 3.36)as compared to controls(4.48+/- 1.09) p value < 0.001.Serum creatinine were also high in cases(1.59+/- 1.39 )as compared to controls ( 0.87+/- 0.29) p value <0.005.Study subgroup with serum uric acid ≥7 mg/dl was associated with high creatinine and high fasting blood sugar levels when compared to subgroup with serum uric acid <7 mg/dl. CONCLUSION: Our study showed increased serum uric acid and serum creatinine levels in cases when compared to controls.There was significant association between high serum uric acid and high creatinine levels in cases.Therefore,it is important to measure serum uric acid and serum creatinine levels in diabetics for early detection of renal pathology.


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