Prediction of success in assisted reproductive technology with the help of morphology of the testis

In the structure of infertile marriage male factor of infertility occurs in about 40-50%. About 30% of infertile men who have sought medical care have oligozoospermia or azoospermia of unknown etiology. The question of the chances of spermatogenesis recovery and increased probability of sperm extraction in repeated assisted reproductive technology (ART) programs is important for both the doctor and the patient.Purpose. To evaluate the morphological changes of spermatogenic epithelium in patients with male infertility in terms of prognosis of ART success.Patients and methods. 264 men with infertility were examined. The scope of clinical study of all patients included: history, examination, determination of blood hormones, study of ejaculate, karyotype, ultrasound. We performed a biopsy of the testis according to the patient's symptoms. Testicular tissue was subjected to morphological examination.Results. Primary infertility was observed in 172 men (65.2%), secondary — 92 (34.8%). 112 (42.4%) patients had severe infertility. The results of morphological studies in these men showed a different degree of violation of spermatogenesis. Based on the study, a diagnostic algorithm of patients with male infertility is proposed, which allows to predict the success of ART taking into account morphological changes in the testicle.Conclusion. On the basis of clinical and morphological study of the features of spermatogenesis of a particular patient a plan can be made for further personal diagnostic and therapeutic measures.

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Improvement in Sperm Parameters With Traditional Iranian Remedy

Journal of Evidence-Based Complementary & Alternative Medicine ◽

10.1177/2156587215627536 ◽

2016 ◽

Vol 22 (2) ◽

pp. 223-226 ◽

Cited By ~ 1

Author(s):

Farnaz Sohrabvand ◽

Somaye Mahroozade ◽

Sodabe Bioos ◽

Seyed Mohammad Nazari ◽

Fataneh Hashem Dabaghian

Keyword(s):

Male Infertility ◽

Traditional Medicine ◽

Assisted Reproductive Technology ◽

Intracytoplasmic Sperm Injection ◽

Sperm Quality ◽

Intrauterine Insemination ◽

Sperm Count ◽

Reproductive Technology ◽

Sperm Parameters ◽

Medicinal Treatment

Introduction. Idiopathic male infertility is a global problem with almost no definite medicinal treatment. Most patients have to go through intrauterine insemination or assisted reproductive technology for achieving fertility. Unfortunately, success rates are low in cases with very low sperm count. Therefore it seems that improvement in sperm quality can have beneficial effects on assisted reproductive technology outcome. Case Report. A 39-year-old man with history of infertility for 6 years was referred to the traditional medicine clinic with a recurrent unsuccessful intracytoplasmic sperm injection trial. His sperm analysis showed severe oligoasthenoteratozoospermia. After taking a traditional remedy he had a remarkable improvement in his sperm parameters, which led to the formation of 8 embryos in the following intracytoplasmic sperm injection cycle. Conclusion. Traditional medicine presents various food and remedy options for treating male infertility. It seems that combination therapy can be beneficial in obtaining better results in treatment of male idiopathic infertility.

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Epigenetic biomarkers in male infertility and its potential use in assisted reproductive technology

10.1016/b978-0-12-823008-4.00015-9 ◽

2022 ◽

pp. 543-572

Author(s):

José Luis García-Giménez ◽

Valter Luiz Maciel ◽

Minerva Ferrer-Buitrago ◽

Salvador Mena-Mollá ◽

Miguel Ruiz-Jorro

Keyword(s):

Male Infertility ◽

Assisted Reproductive Technology ◽

Reproductive Technology ◽

Epigenetic Biomarkers ◽

Potential Use

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Varicocele and Male Infertility: Evidence in the Era of Assisted Reproductive Technology

Reproductive System & Sexual Disorders ◽

10.4172/2161-038x.1000e114 ◽

2013 ◽

Vol 03 (01) ◽

Keyword(s):

Male Infertility ◽

Assisted Reproductive Technology ◽

Reproductive Technology

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Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications

Seminars in Reproductive Medicine ◽

10.1055/s-0038-1677048 ◽

2018 ◽

Vol 36 (03/04) ◽

pp. 195-203

Author(s):

Emre Seli ◽

Scott Morin

Keyword(s):

Assisted Reproductive Technology ◽

Premature Birth ◽

Absolute Risk ◽

Reproductive Technology ◽

Multiple Gestation ◽

Male Factor Infertility ◽

Male Factor ◽

Monogenic Disorder ◽

Increased Risk ◽

Confounding Variables

AbstractThe majority of offspring born following assisted reproductive technology (ART) achieve equivalent development milestones and demonstrate comparable health as spontaneously conceived children. Yet, multiple studies have suggested offspring conceived with ART have slightly increased risk of metabolic derangements, cardiovascular disease, and malignancy. However, the associations observed in these studies often inadequately control for a variety of confounding variables, such as multiple gestation, premature birth, and low birth weight. Furthermore, many studies fail to account for the increased risk of many of these pathologies in the offspring of subfertile women in general. Lastly, the absolute risk of most of the ailments studied is extremely low. In nearly all examples, the number of women who would need to be treated to observe one additional diagnosis is substantially high. When compared with the number of couples who would have remained childless due to severe male factor infertility or would have been exposed to the risk of passing on a severe monogenic disorder, the general increased risks to ART-exposed children is very small.

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