Evaluation and Management of Mallory – Weiss Syndrome: A Review

Upper gastrointestinal bleeding is a symptom of Mallory-Weiss syndrome, which is caused by longitudinal mucosal lacerations (known as Mallory-Weiss tears) near the gastroesophageal junction or gastric cardia. Mallory-Weiss syndrome is rather prevalent, accounting for 3 to 10% of all upper gastrointestinal bleeding episodes. In mild circumstances, the disease may be asymptomatic. Hematemesis is the presenting symptom in 85 percent of patients. Blood is present in varying amounts, ranging from blood-streaked mucous to huge bright red haemorrhage. Other symptoms such as melena, dizziness, or syncope might occur as a result of heavy bleeding. The majority of the time, the bleeding is little and ends on its own. Endoscopy is frequently used to confirm the diagnosis of MWS. Although most patients may be treated with monitoring or conservative medicinal treatment, certain cases require endoscopic or surgical treatment. Despite the fact that MWS is a common cause of nonvariceal upper gastrointestinal bleeding (NVUGIB), little research has been done on it. This article discusses MWS Etiology, epidemiology, evaluation and management.

A review on lupus disease, symptoms and their treatment with traditional medicines

Lupus erythematous is an autoimmune illness that mostly affects women and has no recognized cause. The classical period, the neoclassical period and the modern period are the three periods in the history of lupus erythematous. Important discoveries have occurred at each period allowing for a better understanding of a conditions.Pericarditis, valvular lesions and myocardial dysfunction, particularly mild pericarditis. As a result, echocardiography should be done on SLE patients on a regular basis. Vascular blockage, including coronary arteries can occur as a result of SLE related vasculitis early atherosclerosis or antiphospholipid antibodies. The immune system of the body becomes overactive and targets normal, healthy tissue. Inflammation, swelling and damage to the skin, joints, skin, kidney, blood, heart, and lungs are among the symptoms and medicinal treatment commonly used with the help of ayurvedic treatment, allopathic treatment and homeopathic treatment.

Phytochemical screening and antimicrobial activity of Haematostaphis barteri

The aim of this work was to carry out the phytochemical screening and antimicrobial activities of Haematostaphis barteri. The method of cold maceration was used in the extraction by serial exhaustive extraction method which involves successive extraction with solvents of increasing polarity from a non-polar (hexane) to a more polar solvent (methanol) to ensure that a wide polarity range of compound could be extracted. The results showed that flavonoids, terpenes, terpenes, tannins, and saponins are present in all the leaf extracts. The result of the antimicrobial activity obtained from the extracts of the leaf of Haematostaphis barteri revealed that all the crude extracts of the leaf inhibited or exhibited antibacterial activity against Salmonella paratyphi, Staphylococcus aureus, Escherichia coli, and Penicillium spp. All the extracts did demonstrate antimicrobial activity against Aspergillus niger. The plant H. barteri is commonly used traditionally for the treatment of diarrhoea, wound, headache, malaria, dysentery and fevers. The overall results confirm the significance of the use of the plant in traditional medicinal treatment of diarrhea, wound, headache, malaria, dysentery and fevers, in line with reported claims.

Effect of Aromatherapy with Lavender on Labor Pain: A Literature Review

Background: Controlling labor pains is now an essential part of midwifery care, and aromatherapy is a well-known medicinal treatment for easing labor pains. The aim of this research was to evaluate and analyze the most recent clinical trial results on the effects of lavender aromatherapy on labor pain management. Methods: Several keywords were searched in the MEDLINE/PubMed, Scopus, and Google Scholar databases, including lavender, Lavandula, childbirth, labor, pregnancy, labor pain, aromatherapy, and delivery. Two authors extracted the data, and the Cochran quality management tool was used to assess the consistency of each study. Results: In general, 7 studies were reviewed after checking the titles and abstracts of the studies and eliminating obsolete or low-quality studies. Two studies were conducted in Egypt and Indonesia, and five studies were conducted in Iran. There were a wide variety of qualities in the studies, which could render more quantitative synthesis impractical. Massage aromatherapy was employed in three trials, and inhalation was applied in four studies. All findings suggested that lavender aromatherapy in both methods could reduce active phase labor pain. Conclusion: Although the results of this study showed that lavender aromatherapy suppressed labor pain, more detailed randomized clinical trials with higher precision are needed to achieve an accurate outcome for data generalization regarding the use of labor pain management.

Rhododendron arboreum: A critical review on phytochemicals, health benefits and applications in the food processing industrie

: Rhododendron is a resourceful, evergreen shrub or a small tree with an ornate display of scarlet red or pale pink flowers that belongs to the family Ericaceae. Rhododendron plants are traditionally being used for the medicinal treatment of numerous human ailments like blood dysentery, headache, asthma, cough, stomachache, fever, inflammation, and fungal infections. Rhododendron also has economic, medicinal, and pharmacological importance. Rhododendron has been regarded as a rich source of secondary metabolites. Apart from aesthetic and sacred values, from past times, Rhododendron juice was prepared from the flowers to curb allergies, treat diabetes, and to deal with inflammations. Recent studies have shown several promising activities particularly relaxant, digestive enzyme, antioxidant, antimicrobial, antispasmodic, anticancer, and antagonistic effects. With the rapidly growing popularity of Rhododendron arboreum it is important to have a comprehensive reference for its nutritional benefits with the growing search for natural and health foods. This work aimed to review the recent advances in research carried out to date for purposive evaluation of nutritional quality and potential health benefits of Rhododendron arboreum for its utilization in food processing industries for composing novel value-added products, to achieve high consumer acceptability and health benefits.

Effective Management of Hypothyroidism by Using Ayurvedic Interventions: A Case Report

Hypothyroidism is an endocrine disorder that mainly occurs due to insufficient thyroid gland stimulation or primary gland failure by the pituitary or hypothalamus gland. Symptoms of hypothyroidism include fatigue, gastric trouble, face puffiness with edematous eyelids, retarded nail growth, weight gain, hoarseness of voice, decreased libido, pallor, dry skin, dry hair, alopecia, constipation, abnormal menstrual cycle, muscle cramps, myalgia etc. A 30-year-old married Hindu, non-alcoholic, non-smoking male patient visited OPD of Shuddhi Ayurveda Clinic, Jeena Sikho Lifecare Pvt. Ltd. Noida on 18 November 2020 with known case of subclinical hypothyroidism. On the basis of clinical diagnosis and laboratory investigations, ayurvedic medicines having action on thyroid gland and digestion improvement were prescribed for over a period of six months. After this ayurvedic medicinal treatment for four months i.e. from November 2020 to February 2021, significant results were noted in terms of reduction in level of increased TSH. TSH level was significantly reduced from 181µIU/ml to 0.11 µIU/ml within two months of ayurvedic treatment. Then, there was a mild increase in the TSH level when patient was tested for TFT after four months i.e. on 21st of June 2021, investigated level of TSH was 5.59 µIU/ml. Overall, a satisfactory result was observed in patient clinical conditions proving significant efficacy of ayurvedic treatment.

Development and Characterisation of Antibody-Based Optical Imaging Probes for Inflammatory Bowel Disease

Monoclonal antibodies are an important addition to the medicinal treatment paradigm for IBD patients. While effective, these agents show a high degree of primary and secondary non-response, and methods to predict response are highly desired. Information on drug distribution at the target level is often lacking. Fluorescent endoscopic imaging using labelled antibody drugs may provide insight regarding drug distribution, target engagement and drug response, but these assessments require stable and functional fluorescently-conjugated probes. Infliximab, vedolizumab, adalimumab and ustekinumab were conjugated to IRDye 800CW, IRDye 680LT and ZW800-1. The resulting 12 tracer candidates were analysed and characterised on SE-HPLC, SDS-PAGE, iso-electric focussing (IEF) and ELISA in order to evaluate their feasibility as candidate clinical tracers for cGMP development. Major differences in the conjugation results could be seen for each conjugated drug. For Infliximab, 2 conjugates (800CW and 680LT) showed formation of aggregates, while conjugates of all drugs with ZW800-1 showed reduced fluorescent brightness, reduced purification yield and formation of fragments. All 6 of these candidates were considered unfeasible. From the remaining 6, ustekinumab-680LT showed reduced binding to IL23, and was therefore considered unfeasible. Out of 12 potential tracer candidates, 5 were considered feasible for further development: vedolizumab-800CW, vedolizumab-680LT, adalimumab-800CW, adalimumab-680LT and ustekinumab-800CW. Infliximab-680LT and ustekinumab-680LT failed to meet the standards for this panel, but may be rendered feasible if tracer production methods were further optimized.

​Evaluation of Homologous Platelet Rich Plasma (PRP) Drop and Leucocyte Platelet Rich Fibrin (L-PRF) Membrane for Corneal Ulcer Healing in Dogs

Background: To evaluate use of homologous platelet rich plasma (PRP) drop and leucocyte-platelet rich fibrin (L-PRF) clot/membrane as regenerative therapy for healing of corneal ulcer in dogs and its subsequent comparison with conventional therapy. Methods: In this randomized study, 30 dogs were divided into three groups of 10 animals each. It was ensured each group had grade I, II and III ulcers. Group I received medicinal treatment with antimicrobial and non-steroidal anti-inflammatory eye drop. In Group II PRP drops and in Group III L-PRF membrane was used to evaluate corneal ulcer healing. Homologous platelet concentrates were prepared in laboratory and used for assessment of healing on various grades of corneal ulcer on basis on reduction in size and depth of ulcer, presence of stromal infiltration, scleral involvement, corneal opacity and vascularization. Result: Post treatment, the size of corneal ulcer started to reduce gradually from day 7 onwards. Significant (p≤0.05) reduction was observed from day 10 in group I after instillation of drops Moxifloxacin and Flurbiprofen and in group II after instillation of PRP. It was measured as 5.35 ± 0.63 and 5.20 ± 0.98 mm at day 0, which reduced significantly (p≤0.05) to 3.90 ± 0.50 and 3.10 ± 0.98 mm at day 10 in group I and group II respectively. In group III there was significant reduction in size of ulcer from day 0 to day 7 measuring 7.80 ± 1.05 and 0.20 ± 0.11mm respectively. Thereafter, from day 10 onwards complete sealing of ulcer was observed in all the cases. Post treatment there was no significant reduction in corneal opacity from day 0 to day 30 in group I dogs and corneal opacity persisted specially in grade II and grade III ulcers. There was significant reduction (p≤0.05) in opacity from 2.90 ± 0.35 to 2.10 ± 0.38 and 3.00 ± 0.37 to 2.40 ± 0.34 in group II and group III dogs from day 0 to day 10 respectively. In group I, II and III there was significant (p≤0.05) reduction in vascularization from 1.50±0.30 to 1.20±0.13, 1.30±0.37 to 0.60±0.22 and 1.40±0.31 to 0.40±0.31 from day 0 to day 15 respectively. There was a significant reduction in vascularization on day 15 in group II and group III compared to group I animals.

Perceptions among diabetic patients in the ultra-orthodox Jewish community regarding medication adherence: a qualitative study

Background Promoting a healthy lifestyle and achieving strict adherence to medical treatment among patients with diabetes are key objectives in public health. Yet health behaviors are often culturally driven, especially in closed religious communities. This study seeks to reveal key cultural-religious factors, attitudes and behaviors characterizing the lifestyle in one such closed community—the ultra-Orthodox Jewish community—by understanding the attitudes of ultra-Orthodox patients with diabetes toward coping with their illness and the factors impacting their adherence to medicinal treatment. Method Qualitative interviews were conducted with 16 ultra-Orthodox patients with diabetes using a semi-structured, in-depth questionnaire. Results Three main themes emerged: 1) “The disease as a secret”: Hiding the disease among patients with diabetes in ultra-Orthodox society; 2) “Distinguishing between sacred and secular occasions”: ultra-Orthodox diabetes patients distinguish between treatment adherence on weekdays and treatment adherence on holidays or special occasions; 3) “Ask the rabbi”: In cases of dilemmas that involved conflicts between halakhic rulings and doctors’ instructions, the rabbi’s decision was usually the final one. Conclusions The findings of this study may help provide an in-depth understanding of the obstacles and motives of ultra-Orthodox patients in adhering to medicinal treatment of diabetes in particular and to medicinal treatment in general, thus helping family physicians who treat this population provide optimal and appropriate treatment.